Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes
Goodwin, Nicole C, Ding, Zhi-Ming, Harrison, Bryce A, Strobel, Eric D, Harris, Angela L, Smith, Melinda, Thompson, Andrea Y, Xiong, Wendy, Mseeh, Faika, Bruce, Debra J, Diaz, Damaris, Gopinathan, Suma, Li, Ling, O’Neill, Emily, Thiel, Mary, Wilson, Alan G. E, Carson, Kenneth G, Powell, David R, Rawlins, David B
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma
Harrison, Bryce A, Almstead, Zheng Y, Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C, Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R, Whitlock, N. Andrew, Gopinathan, Suma, McKnight, Beth, Wang, Shuli, Patel, Nita, Wilson, Alan G. E, Hamman, Brian D, Rice, Dennis S, Rawlins, David B
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma
Harrison, Bryce A, Whitlock, N. Andrew, Voronkov, Michael V, Almstead, Zheng Y, Gu, Kun-jian, Mabon, Ross, Gardyan, Michael, Hamman, Brian D, Allen, Jason, Gopinathan, Suma, McKnight, Beth, Crist, Mike, Zhang, Yulian, Liu, Ying, Courtney, Lawrence F, Key, Billie, Zhou, Julia, Patel, Nita, Yates, Phil W, Liu, Qingyun, Wilson, Alan G. E, Kimball, S. David, Crosson, Craig E, Rice, Dennis S, Rawlins, David B
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Early toxicology signal generation in the mouse
Kramer, Jeffrey A, O'Neill, Emily, Phillips, Megan E, Bruce, Debra, Smith, Traci, Albright, Melinda M, Bellum, Sairam, Gopinathan, Suma, Heydorn, William E, Liu, Xuemei, Nouraldeen, Amr, Payne, Bobby Joe, Read, Robert, Vogel, Peter, Yu, Xiang-Qing, Wilson, Alan G E
Published in Toxicologic pathology (01.04.2010)
Published in Toxicologic pathology (01.04.2010)
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Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
Tarver, James E., Pabba, Praveen K., Barbosa, Joseph, Han, Qiang, Gardyan, Michael W., Brommage, Robert, Thompson, Andrea Y., Schmidt, James M., Wilson, Alan G.E., He, Wei, Lombardo, Victoria K., Carson, Kenneth G.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Journal Article
Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes
Goodwin, Nicole C, Mabon, Ross, Harrison, Bryce A, Shadoan, Melanie K, Almstead, Zheng Y, Xie, Yiling, Healy, Jason, Buhring, Lindsey M, DaCosta, Christopher M, Bardenhagen, Jennifer, Mseeh, Faika, Liu, Qingyun, Nouraldeen, Amr, Wilson, Alan G. E, Kimball, S. David, Powell, David R, Rawlins, David B
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
Han, Qiang, Pabba, Praveen K., Barbosa, Joseph, Mabon, Ross, Healy, Jason P., Gardyan, Michael W., Terranova, Kristen M., Brommage, Robert, Thompson, Andrea Y., Schmidt, James M., Wilson, Alan G.E., Xu, Xiaolian, Tarver, James E., Carson, Kenneth G.
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
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Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat
Lu, Jing J, Crimin, Kimberly, Goodwin, Jay T, Crivori, Patrizia, Orrenius, Christian, Xing, Li, Tandler, Peter J, Vidmar, Thomas J, Amore, Benny M, Wilson, Alan G. E, Stouten, Pieter F. W, Burton, Philip S
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study
Germani, Massimiliano, Crivori, Patrizia, Rocchetti, Maurizio, Burton, Philip S., Wilson, Alan G.E., Smith, Mark E., Poggesi, Italo
Published in European journal of pharmaceutical sciences (01.07.2007)
Published in European journal of pharmaceutical sciences (01.07.2007)
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Evaluation of a Physiologically‐Based Pharmacokinetic Approach for Simulating the First‐Time‐In‐Animal Study
Germani, Massimiliano, Crivori, Patrizia, Rocchetti, Maurizio, Burton, Philip S., Wilson, Alan G. E., Smith, Mark E., Poggesi, Italo
Published in Basic & clinical pharmacology & toxicology (01.03.2005)
Published in Basic & clinical pharmacology & toxicology (01.03.2005)
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Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors
Jessop, Theodore C., Tarver, James E., Carlsen, Marianne, Xu, Amy, Healy, Jason P., Heim-Riether, Alexander, Fu, Qinghong, Taylor, Jerry A., Augeri, David J., Shen, Min, Stouch, Terry R., Swanson, Ronald V., Tari, Leslie W., Hunter, Michael, Hoffman, Isaac, Keyes, Philip E., Yu, Xuan-Chuan, Miranda, Maricar, Liu, Qingyun, Swaffield, Jonathan C., David Kimball, S., Nouraldeen, Amr, Wilson, Alan G.E., Foushee, Ann Marie DiGeorge, Jhaver, Kanchan, Finch, Rick, Anderson, Steve, Oravecz, Tamas, Carson, Kenneth G.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
Tarver, James E., Jessop, Theodore C., Carlsen, Marianne, Augeri, David J., Fu, Qinghong, Healy, Jason P., Heim-Riether, Alexander, Xu, Amy, Taylor, Jerry A., Shen, Min, Keyes, Philip E., David Kimball, S., Yu, Xuan-Chuan, Miranda, Maricar, Liu, Qingyun, Swaffield, Jonathan C., Nouraldeen, Amr, Wilson, Alan G.E., Finch, Rick, Jhaver, Kanchan, Foushee, Ann Marie DiGeorge, Anderson, Steve, Oravecz, Tamas, Carson, Kenneth G.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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In vivo toxicology of excipients commonly employed in drug discovery in rats
Gopinathan, Suma, O’Neill, Emily, Rodriguez, Lawrence A., Champ, Rose, Phillips, Megan, Nouraldeen, Amr, Wendt, Mary, Wilson, Alan G.E., Kramer, Jeffrey A.
Published in Journal of pharmacological and toxicological methods (01.09.2013)
Published in Journal of pharmacological and toxicological methods (01.09.2013)
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