ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
Evans, Charles E., Miners, James S., Piva, Giulia, Willis, Christine L., Heard, David M., Kidd, Emma J., Good, Mark A., Kehoe, Patrick G.
Published in Acta neuropathologica (01.03.2020)
Published in Acta neuropathologica (01.03.2020)
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Journal Article
Core Steps to the Azaphilone Family of Fungal Natural Products
Williams, Katherine, Greco, Claudio, Bailey, Andrew M., Willis, Christine L.
Published in Chembiochem : a European journal of chemical biology (03.11.2021)
Published in Chembiochem : a European journal of chemical biology (03.11.2021)
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Journal Article
Strobilurin biosynthesis in Basidiomycete fungi
Nofiani, Risa, de Mattos-Shipley, Kate, Lebe, Karen E., Han, Li-Chen, Iqbal, Zafar, Bailey, Andrew M., Willis, Christine L., Simpson, Thomas J., Cox, Russell J.
Published in Nature communications (26.09.2018)
Published in Nature communications (26.09.2018)
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Journal Article
The Catalytic Mechanism of a Natural Diels–Alderase Revealed in Molecular Detail
Byrne, Matthew J, Lees, Nicholas R, Han, Li-Chen, van der Kamp, Marc W, Mulholland, Adrian J, Stach, James E. M, Willis, Christine L, Race, Paul R
Published in Journal of the American Chemical Society (18.05.2016)
Published in Journal of the American Chemical Society (18.05.2016)
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Journal Article
Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
Alberti, Fabrizio, Khairudin, Khairunisa, Venegas, Edith Rodriguez, Davies, Jonathan A., Hayes, Patrick M., Willis, Christine L., Bailey, Andy M., Foster, Gary D.
Published in Nature communications (28.11.2017)
Published in Nature communications (28.11.2017)
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Journal Article
Ambruticins: tetrahydropyran ring formation and total synthesis
Bowen, James I, Wang, Luoyi, Crump, Matthew P, Willis, Christine L
Published in Organic & biomolecular chemistry (21.07.2021)
Published in Organic & biomolecular chemistry (21.07.2021)
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Journal Article
Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis
Bowen, James I, Zhong, Xiaotong, Gao, Kaining, Reed, Benjamin, Crump, Matthew P, Wang, Luoyi, Willis, Christine L
Published in Chemical science (Cambridge) (03.04.2024)
Published in Chemical science (Cambridge) (03.04.2024)
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Journal Article
Divergent Tandem Acyl Carrier Proteins Necessitate In-Series Polyketide Processing in the Leinamycin Family
Phillips, Annabel P, Winter, Ashley J, Hooper, Chloe M, Williams, Christopher, Crosby, John, Willis, Christine L, Crump, Matthew Philip
Published in Angewandte Chemie International Edition (26.09.2024)
Published in Angewandte Chemie International Edition (26.09.2024)
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Journal Article
Resistance to and synthesis of the antibiotic mupirocin
Thomas, Christopher M, Hothersall, Joanne, Willis, Christine L, Simpson, Thomas J
Published in Nature reviews. Microbiology (01.04.2010)
Published in Nature reviews. Microbiology (01.04.2010)
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Journal Article
Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi
Greco, Claudio, de Mattos-Shipley, Kate, Bailey, Andrew M, Mulholland, Nicholas P, Vincent, Jason L, Willis, Christine L, Cox, Russell J, Simpson, Thomas J
Published in Chemical science (Cambridge) (14.03.2019)
Published in Chemical science (Cambridge) (14.03.2019)
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Journal Article
An Integrated Module Performs Selective ‘Online’ Epoxidation in the Biosynthesis of the Antibiotic Mupirocin
Winter, Ashley J., de Courcy‐Ireland, Felix, Phillips, Annabel P., Barker, Joseph M., Bakar, Nurfarhanim A., Akter, Nahida, Wang, Luoyi, Song, Zhongshu, Crosby, John, Williams, Christopher, Willis, Christine L., Crump, Matthew P.
Published in Angewandte Chemie International Edition (16.10.2024)
Published in Angewandte Chemie International Edition (16.10.2024)
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Journal Article
Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform
Alberti, Fabrizio, Khairudin, Khairunisa, Davies, Jonathan A, Sangmalee, Suphattra, Willis, Christine L, Foster, Gary D, Bailey, Andy M
Published in Chemical science (Cambridge) (05.04.2023)
Published in Chemical science (Cambridge) (05.04.2023)
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Journal Article
Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production
Bailey, Andy M., Alberti, Fabrizio, Kilaru, Sreedhar, Collins, Catherine M., de Mattos-Shipley, Kate, Hartley, Amanda J., Hayes, Patrick, Griffin, Alison, Lazarus, Colin M., Cox, Russell J., Willis, Christine L., O’Dwyer, Karen, Spence, David W., Foster, Gary D.
Published in Scientific reports (04.05.2016)
Published in Scientific reports (04.05.2016)
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Journal Article
Diastereodivergent Synthesis of Trisubstituted Alkenes through Protodeboronation of Allylic Boronic Esters: Application to the Synthesis of the Californian Red Scale Beetle Pheromone
Hesse, Matthew J., Butts, Craig P., Willis, Christine L., Aggarwal, Varinder K.
Published in Angewandte Chemie International Edition (07.12.2012)
Published in Angewandte Chemie International Edition (07.12.2012)
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Journal Article
Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase
Winter, Ashley J., Khanizeman, R. Nisha, Barker‐Mountford, Abigail M. C., Devine, Andrew J., Wang, Luoyi, Song, Zhongshu, Davies, Jonathan A., Race, Paul R., Williams, Christopher, Simpson, Thomas J., Willis, Christine L., Crump, Matthew P.
Published in Angewandte Chemie International Edition (20.11.2023)
Published in Angewandte Chemie International Edition (20.11.2023)
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Journal Article