Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway
Irvine, Alistair G, Wallis, A Katrine, Sanghera, Narinder, Rowe, Michelle L, Ruddock, Lloyd W, Howard, Mark J, Williamson, Richard A, Blindauer, Claudia A, Freedman, Robert B
Published in PloS one (20.01.2014)
Published in PloS one (20.01.2014)
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Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region
Byrne, Lee J, Sidhu, Ateesh, Wallis, A Katrine, Ruddock, Lloyd W, Freedman, Robert B, Howard, Mark J, Williamson, Richard A
Published in Biochemical journal (15.10.2009)
Published in Biochemical journal (15.10.2009)
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Alternative Conformations of the x Region of Human Protein Disulphide-Isomerase Modulate Exposure of the Substrate Binding b’ Domain
Nguyen, Van Dat, Wallis, Katrine, Howard, Mark J., Haapalainen, Antti M., Salo, Kirsi E.H., Saaranen, Mirva J., Sidhu, Ateesh, Wierenga, Rik K., Freedman, Robert B., Ruddock, Lloyd W., Williamson, Richard A.
Published in Journal of molecular biology (28.11.2008)
Published in Journal of molecular biology (28.11.2008)
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GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization
Tralau-Stewart, Cathy J, Williamson, Richard A, Nials, Anthony T, Gascoigne, Michele, Dawson, John, Hart, Graham J, Angell, Anthony D R, Solanke, Yemisi E, Lucas, Fiona S, Wiseman, Joanne, Ward, Peter, Ranshaw, Lisa E, Knowles, Richard G
Published in The Journal of pharmacology and experimental therapeutics (01.04.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2011)
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High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility
Amin, Nader T, Wallis, A Katrine, Wells, Stephen A, Rowe, Michelle L, Williamson, Richard A, Howard, Mark J, Freedman, Robert B
Published in Biochemical journal (01.03.2013)
Published in Biochemical journal (01.03.2013)
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Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase
Pirneskoski, Annamari, Klappa, Peter, Lobell, Mario, Williamson, Richard A., Byrne, Lee, Alanen, Heli I., Salo, Kirsi E.H., Kivirikko, Kari I., Freedman, Robert B., Ruddock, Lloyd W.
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Molecular Features Governing the Stability and Specificity of Functional Complex Formation by Mycobacterium tuberculosis CFP-10/ESAT-6 Family Proteins
Lightbody, Kirsty L., Ilghari, Dariush, Waters, Lorna C., Carey, Gemma, Bailey, Mark A., Williamson, Richard A., Renshaw, Philip S., Carr, Mark D.
Published in The Journal of biological chemistry (20.06.2008)
Published in The Journal of biological chemistry (20.06.2008)
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ERp27, a New Non-catalytic Endoplasmic Reticulum-located Human Protein Disulfide Isomerase Family Member, Interacts with ERp57
Alanen, Heli I., Williamson, Richard A., Howard, Mark J., Hatahet, Feras S., Salo, Kirsi E.H., Kauppila, Annika, Kellokumpu, Sakari, Ruddock, Lloyd W.
Published in The Journal of biological chemistry (03.11.2006)
Published in The Journal of biological chemistry (03.11.2006)
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Functional Characterization of ERp18, a New Endoplasmic Reticulum-located Thioredoxin Superfamily Member
Alanen, Heli I., Williamson, Richard A., Howard, Mark J., Lappi, Anna-Kaisa, Jäntti, Heli P., Rautio, Sini M., Kellokumpu, Sakari, Ruddock, Lloyd W.
Published in The Journal of biological chemistry (01.08.2003)
Published in The Journal of biological chemistry (01.08.2003)
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The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity
Davis, T Gregg, Peterson, John J, Kou, Jen-Pyng, Capper-Spudich, Elizabeth A, Ball, Doug, Nials, Anthony T, Wiseman, Joanne, Solanke, Yemisi E, Lucas, Fiona S, Williamson, Richard A, Ferrari, Livia, Wren, Paul, Knowles, Richard G, Barnette, Mary S, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6
Renshaw, Philip S, Lightbody, Kirsty L, Veverka, Vaclav, Muskett, Fred W, Kelly, Geoff, Frenkiel, Thomas A, Gordon, Stephen V, Hewinson, R Glyn, Burke, Bernard, Norman, Jim, Williamson, Richard A, Carr, Mark D
Published in The EMBO journal (20.07.2005)
Published in The EMBO journal (20.07.2005)
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Combined ligand-observe (19)F and protein-observe (15)N,(1)H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase
Richards, Kirsty L, Rowe, Michelle L, Hudson, Paul B, Williamson, Richard A, Howard, Mark J
Published in Scientific reports (20.01.2016)
Published in Scientific reports (20.01.2016)
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SlyA Protein Activates fimB Gene Expression and Type 1 Fimbriation in Escherichia coli K-12
McVicker, Gareth, Sun, Lei, Sohanpal, Baljinder K., Gashi, Krishna, Williamson, Richard A., Plumbridge, Jacqueline, Blomfield, Ian C.
Published in The Journal of biological chemistry (16.09.2011)
Published in The Journal of biological chemistry (16.09.2011)
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The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity
Murphy, Gillian, Houbrechts, Annick, Cockett, Mark I, Williamson, Richard A, O'Shea, Mark, Docherty, Andrew J. P
Published in Biochemistry (Easton) (01.08.1991)
Published in Biochemistry (Easton) (01.08.1991)
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Synthesis and Characterization of 111In−DTPA−N-TIMP-2: A Radiopharmaceutical for Imaging Matrix Metalloproteinase Expression
Giersing, Birgitte K, Rae, Michael T, CarballidoBrea, Montserrat, Williamson, Richard A, Blower, Philip J
Published in Bioconjugate chemistry (21.11.2001)
Published in Bioconjugate chemistry (21.11.2001)
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Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein-peptide interactions
Wagstaff, Jane L, Vallath, Sabari, Marshall, John F, Williamson, Richard A, Howard, Mark J
Published in Chemical communications (Cambridge, England) (28.10.2010)
Published in Chemical communications (Cambridge, England) (28.10.2010)
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