PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma
Smeester, Branden A., Slipek, Nicholas J., Pomeroy, Emily J., Laoharawee, Kanut, Osum, Sara H., Larsson, Alex T., Williams, Kyle B., Stratton, Natalie, Yamamoto, Kenta, Peterson, Joseph J., Rathe, Susan K., Mills, Lauren J., Hudson, Wendy A., Crosby, Margaret R., Wang, Minjing, Rahrmann, Eric P., Moriarity, Branden S., Largaespada, David A.
Published in Bone (New York, N.Y.) (01.07.2020)
Published in Bone (New York, N.Y.) (01.07.2020)
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Journal Article
Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas
Williams, Kyle B, Marley, Andrew R, Tibbitts, Justin, Moertel, Christopher L, Johnson, Kimberly J, Linden, Michael A, Largaespada, David A, Marcotte, Erin L
Published in BMC research notes (17.10.2023)
Published in BMC research notes (17.10.2023)
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Journal Article
Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV
Hastie, Jessica L, Williams, Kyle B, Sepúlveda, Carolina, Houtman, Jon C, Forest, Katrina T, Ellermeier, Craig D
Published in PLoS genetics (01.10.2014)
Published in PLoS genetics (01.10.2014)
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Journal Article
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation
Hastie, Jessica L, Williams, Kyle B, Bohr, Lindsey L, Houtman, Jon C, Gakhar, Lokesh, Ellermeier, Craig D
Published in PLoS genetics (01.09.2016)
Published in PLoS genetics (01.09.2016)
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Journal Article
Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK
Ramkissoon, Annmarie, Chaney, Katherine E, Milewski, David, Williams, Kyle B, Williams, Rory L, Choi, Kwangmin, Miller, Adam, Kalin, Tanya V, Pressey, Joseph G, Szabo, Sara, Azam, Mohammad, Largaespada, David A, Ratner, Nancy
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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Journal Article
Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma
Smeester, Branden A, Draper, Garrett M, Slipek, Nicholas J, Larsson, Alex T, Stratton, Natalie, Pomeroy, Emily J, Becklin, Kelsie L, Yamamoto, Kenta, Williams, Kyle B, Laoharawee, Kanut, Peterson, Joseph J, Abrahante, Juan E, Rathe, Susan K, Mills, Lauren J, Crosby, Margaret R, Hudson, Wendy A, Rahrmann, Eric P, Largaespada, David A, Moriarity, Branden S
Published in Molecular cancer therapeutics (01.12.2020)
Published in Molecular cancer therapeutics (01.12.2020)
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Journal Article
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology
Larsson, Alex T, Bhatia, Himanshi, Calizo, Ana, Pollard, Kai, Zhang, Xiaochun, Conniff, Eric, Tibbitts, Justin F, Rono, Elizabeth, Cummins, Katherine, Osum, Sara H, Williams, Kyle B, Crampton, Alexandra L, Jubenville, Tyler, Schefer, Daniel, Yang, Kuangying, Lyu, Yang, Pino, James C, Bade, Jessica, Gross, John M, Lisok, Alla, Dehner, Carina A, Chrisinger, John S A, He, Kevin, Gosline, Sara J C, Pratilas, Christine A, Largaespada, David A, Wood, David K, Hirbe, Angela C
Published in Neuro-oncology (Charlottesville, Va.) (02.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (02.11.2023)
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Journal Article
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
Isakson, Sara H., Rizzardi, Anthony E., Coutts, Alexander W., Carlson, Daniel F., Kirstein, Mark N., Fisher, James, Vitte, Jeremie, Williams, Kyle B., Pluhar, G. Elizabeth, Dahiya, Sonika, Widemann, Brigitte C., Dombi, Eva, Rizvi, Tilat, Ratner, Nancy, Messiaen, Ludwine, Stemmer-Rachamimov, Anat O., Fahrenkrug, Scott C., Gutmann, David H., Giovannini, Marco, Moertel, Christopher L., Largaespada, David A., Watson, Adrienne L.
Published in Communications biology (01.01.2018)
Published in Communications biology (01.01.2018)
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Journal Article
Nuclear Magnetic Resonance Solution Structure of the Peptidoglycan-Binding SPOR Domain from Escherichia coli DamX: Insights into Septal Localization
Williams, Kyle B, Yahashiri, Atsushi, Arends, S. J. Ryan, Popham, David L, Fowler, C. Andrew, Weiss, David S
Published in Biochemistry (Easton) (29.01.2013)
Published in Biochemistry (Easton) (29.01.2013)
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Journal Article
Clostridium difficile extracytoplasmic function σ factor σV regulates lysozyme resistance and is necessary for pathogenesis in the hamster model of infection
Ho, Theresa D, Williams, Kyle B, Chen, Yan, Helm, Richard F, Popham, David L, Ellermeier, Craig D
Published in Infection and immunity (01.06.2014)
Published in Infection and immunity (01.06.2014)
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Journal Article
Abstract 6011: Methylation profiling reveals the role of PRC2 in regulating DNA methylome changes in malignant peripheral nerve sheath tumors
Stehn, Christopher M., Bhunia, Minu, Williams, Kyle B., Larsson, Alex T., Largaespada, David A.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 1614: Creation of malignant peripheral nerve sheath tumor models deficient for polycomb repressive complex 2 and identification of therapeutic vulnerabilities
Williams, Kyle B., Larsson, Alex, Tibbits, Justin, Moertel, Christopher L., Largaespada, David A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 1615: Developing a novel model of neurofibromatosis type 1 associated malignant peripheral nerve sheath tumors using induced pluripotent stem cells
Draper, Garrett M., Panken, Daniel, Patchava, Mahathi, Hudson, Wendy, Williams, Kyle B., Largaespada, David A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for [sigma].sup.V Activation
Hastie, Jessica L, Williams, Kyle B, Bohr, Lindsey L, Houtman, Jon C, Gakhar, Lokesh, Ellermeier, Craig D
Published in PLoS genetics (07.09.2016)
Published in PLoS genetics (07.09.2016)
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Journal Article
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for [sigma] V Activation
Hastie, Jessica L, Williams, Kyle B, Bohr, Lindsey L, Houtman, Jon C, Gakhar, Lokesh, Ellermeier, Craig D
Published in PLoS genetics (01.09.2016)
Published in PLoS genetics (01.09.2016)
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Journal Article