Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer
Leal, Ana S, Williams, Charlotte R, Royce, Darlene B, Pioli, Patricia A, Sporn, Michael B, Liby, Karen T
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Published in Cancer letters (28.05.2017)
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Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis
To, Ciric, Ringelberg, Carol S, Royce, Darlene B, Williams, Charlotte R, Risingsong, Renee, Sporn, Michael B, Liby, Karen T
Published in Carcinogenesis (New York) (01.07.2015)
Published in Carcinogenesis (New York) (01.07.2015)
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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
Yates, Melinda S., Tran, Quynh T., Dolan, Patrick M., Osburn, William O., Shin, Soona, McCulloch, Colin C., Silkworth, Jay B., Taguchi, Keiko, Yamamoto, Masayuki, Williams, Charlotte R., Liby, Karen T., Sporn, Michael B., Sutter, Thomas R., Kensler, Thomas W.
Published in Carcinogenesis (New York) (01.06.2009)
Published in Carcinogenesis (New York) (01.06.2009)
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Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease
Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby
Published in Antioxidants & redox signaling (10.01.2013)
Published in Antioxidants & redox signaling (10.01.2013)
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The PARP Inhibitors, Veliparib and Olaparib, Are Effective Chemopreventive Agents for Delaying Mammary Tumor Development in BRCA1-deficient Mice
CIRIC TO, KIM, Eun-Hee, ROYCE, Darlene B, WILLIAMS, Charlotte R, COLLINS, Ryan M, RISINGSONG, Renee, SPORN, Michael B, LIBY, Karen T
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2014)
Published in Cancer prevention research (Philadelphia, Pa.) (01.07.2014)
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The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice
LIBY, Karen, ROYCE, Darlene B, WILLIAMS, Charlotte R, RISINGSONG, Renee, YORE, Mark M, HONDA, Tadashi, GRIBBLE, Gordon W, DMITROVSKY, Ethan, SPORN, Thomas A, SPORN, Michael B
Published in Cancer research (Chicago, Ill.) (15.03.2007)
Published in Cancer research (Chicago, Ill.) (15.03.2007)
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Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
Liby, Karen, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Yore, Mark M, Honda, Tadashi, Gribble, Gordon W, Lamph, William W, Vannini, Nicola, Sogno, Ilaria, Albini, Adriana, Sporn, Michael B
Published in Clinical cancer research (15.07.2008)
Published in Clinical cancer research (15.07.2008)
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko
Published in Cancer research (Chicago, Ill.) (01.06.2005)
Published in Cancer research (Chicago, Ill.) (01.06.2005)
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Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer
Liby, Karen T, Royce, Darlene B, Risingsong, Renee, Williams, Charlotte R, Maitra, Anirban, Hruban, Ralph H, Sporn, Michael B
Published in Cancer prevention research (Philadelphia, Pa.) (01.11.2010)
Published in Cancer prevention research (Philadelphia, Pa.) (01.11.2010)
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The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice
Cao, Martine, Royce, Darlene B, Risingsong, Renee, Williams, Charlotte R, Sporn, Michael B, Liby, Karen T
Published in Cancer prevention research (Philadelphia, Pa.) (01.01.2016)
Published in Cancer prevention research (Philadelphia, Pa.) (01.01.2016)
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The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells
LIBY, Karen, VOONG, Nga, WILLIAMS, Charlotte R, RISINGSONG, Renee, ROYCE, Darlene B, HONDA, Tadashi, GRIBBLE, Gordon W, SPORN, Michael B, LETTERIO, John J
Published in Clinical cancer research (15.07.2006)
Published in Clinical cancer research (15.07.2006)
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Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells
Canfield, Kaleigh, Li, Jiaqi, Wilkins, Owen M., Morrison, Meghan M, Ung, Matthew, Wells, Wendy, Williams, Charlotte R., Liby, Karen T, Vullhorst, Detlef, Buonanno, Andres, Hu, Huizhong, Schiff, Rachel, Cook, Rebecca S, Kurokawa, Manabu
Published in Cell cycle (Georgetown, Tex.) (16.02.2015)
Published in Cell cycle (Georgetown, Tex.) (16.02.2015)
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Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice
Liby, Karen, Risingsong, Renee, Royce, Darlene B, Williams, Charlotte R, Ma, Tian, Yore, Mark M, Sporn, Michael B
Published in Cancer prevention research (Philadelphia, Pa.) (01.12.2009)
Published in Cancer prevention research (Philadelphia, Pa.) (01.12.2009)
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Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
Liby, Karen, Honda, Tadashi, Williams, Charlotte R., Risingsong, Renee, Royce, Darlene B., Suh, Nanjoo, Dinkova-Kostova, Albena T., Stephenson, Katherine K., Talalay, Paul, Sundararajan, Chitra, Gribble, Gordon W., Sporn, Michael B.
Published in Molecular cancer therapeutics (01.07.2007)
Published in Molecular cancer therapeutics (01.07.2007)
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The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer
LIBY, Karen, RENDI, Mara, KIM, Heetae, BROWN, Powel, SPORN, Michael B, SUH, Nanjoo, ROYCE, Darlene B, RISINGSONG, Renee, WILLIAMS, Charlotte R, LAMPH, William, LABRIE, Fernand, KRAJEWSKI, Stan, XIAOCHUN XU
Published in Clinical cancer research (01.10.2006)
Published in Clinical cancer research (01.10.2006)
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The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo
PLACE, Andrew E, NANJOO SUH, ROSEN, Evan, SPORN, Michael B, WILLIAMS, Charlotte R, RISINGSONG, Renee, HONDA, Tadashi, HONDA, Yukiko, GRIBBLE, Gordon W, LEESNITZER, Lisa M, STIMMEL, Julie B, WILLSON, Timothy M
Published in Clinical cancer research (01.07.2003)
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Published in Clinical cancer research (01.07.2003)
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A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
Liby, Karen, Yore, Mark M, Roebuck, Bill D, Baumgartner, Karen J, Honda, Tadashi, Sundararajan, Chitra, Yoshizawa, Hidenori, Gribble, Gordon W, Williams, Charlotte R, Risingsong, Renee, Royce, Darlene B, Dinkova-Kostova, Albena T, Stephenson, Katherine K, Egner, Patricia A, Yates, Melinda S, Groopman, John D, Kensler, Thomas W, Sporn, Michael B
Published in Cancer research (Chicago, Ill.) (15.08.2008)
Published in Cancer research (Chicago, Ill.) (15.08.2008)
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A New Rexinoid, NRX194204, Prevents Carcinogenesis in Both the Lung and Mammary Gland
LIBY, Karen, ROYCE, Darlene B, RISINGSONG, Renee, WILLIAMS, Charlotte R, WOOD, Matthew D, CHANDRARATNA, Roshantha A, SPORN, Michael B
Published in Clinical cancer research (15.10.2007)
Published in Clinical cancer research (15.10.2007)
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Prevention and Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor Modulator, Arzoxifene, and a New Rexinoid, LG 100268
Suh, Nanjoo, Lamph, William W, Glasebrook, Andrew L, Grese, Timothy A, Palkowitz, Alan D, Williams, Charlotte R, Risingsong, Renee, Farris, M Rendi, Heyman, Richard A, Sporn, Michael B
Published in Clinical cancer research (01.10.2002)
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Published in Clinical cancer research (01.10.2002)
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