Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
MENDEL, D. B, TAI, C. Y, LEW, W, WILLIAMS, M. A, ZHANG, L, CHEN, M. S, BISCHOFBERGER, N, KIM, C. U, ESCARPE, P. A, LI, W, SIDWELL, R. W, HUFFMAN, J. H, SWEET, C, JAKEMAN, K. J, MERSON, J, LACY, S. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Practical Total Synthesis of the Anti-Influenza Drug GS-4104
Rohloff, John C, Kent, Kenneth M, Postich, Michael J, Becker, Mark W, Chapman, Harlan H, Kelly, Daphne E, Lew, Willard, Louie, Michael S, McGee, Lawrence R, Prisbe, Ernest J, Schultze, Lisa M, Yu, Richard H, Zhang, Lijun
Published in Journal of organic chemistry (26.06.1998)
Published in Journal of organic chemistry (26.06.1998)
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Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
TAI, C. Y, ESCARPE, P. A, SIDWELL, R. W, WILLIAMS, M. A, LEW, W, HUIWEI WU, KIM, C. U, MENDEL, D. B
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
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Journal Article
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C., Doerffler, Edward, Clarke, Michael O., Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M., Barauskas, Ona, Feng, Joy Y., Xu, Yili, Lee, Gary, Rheingold, Arnold L., Ray, Adrian S., Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A., Bavari, Sina, Cihlar, Tomas, Lo, Michael K., Warren, Travis K., Mackman, Richard L.
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Metabolism of the Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat
SWEENY, D. J, LYNCH, G, BIDGOOD, A. M, LEW, W, WANG, K.-Y, CUNDY, K. C
Published in Drug metabolism and disposition (01.07.2000)
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Published in Drug metabolism and disposition (01.07.2000)
Journal Article
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Williams, Matthew A., Lew, Willard, Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Laver, W.Graeme, Stevens, Raymond C., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
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Journal Article
Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients
Cho, Aesop, Zhang, Lijun, Xu, Jie, Lee, Rick, Butler, Thomas, Metobo, Sammy, Aktoudianakis, Vangelis, Lew, Willard, Ye, Hong, Clarke, Michael, Doerffler, Edward, Byun, Daniel, Wang, Ting, Babusis, Darius, Carey, Anne C., German, Polina, Sauer, Dorothea, Zhong, Weidong, Rossi, Stephen, Fenaux, Martijn, McHutchison, John G., Perry, Jason, Feng, Joy, Ray, Adrian S., Kim, Choung U.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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C3-Thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R,4R,5S)-4-acetamido-5-amino-3-propoxyl-1-cyclohexene-1-carboxylic acid
Lew, Willard, Williams, Matthew A., Mendel, Dirk B., Escarpe, Paul A., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.07.1997)
Published in Bioorganic & medicinal chemistry letters (01.07.1997)
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Journal Article
METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS USEFUL FOR TREATING RETROVIRIDAE VIRAL INFECTION
WANG XIANGHONG, SACHIN DHAR, WILLARD LEW, DIETRICH P STEINHUEBEL, AMANDA LYNN VANDEHEY, ALEX GOLDBERG, SHI BIN, GEDIMINAS BRIZGYS, LARS V HEUMANN, SHAHROKH KAZERANI, NGO VINH XUAN, HUANG ZILIN, KEVIN MCCORMACK ALLAN, NATHANIEL THOMAS KADUNCE, CHLOE YUY WONG, BRIAN MICHAEL O'KEEFE, TSE WINSTON C, BENJAMIN JAMES ROBERTS, ANNA MICHELLE WAGNER, SCOTT ALAN WOLCKENHAUER, IAN JAMES DOXSEE, JENNIFER R ZHANG, TREVOR JAMES RAINEY
Year of Publication 19.01.2024
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Year of Publication 19.01.2024
Patent
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
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Discovery of a potent and selective Aurora kinase inhibitor
Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity
Kim, Choung U, Lew, Willard, Williams, Matthew A, Liu, Hongtao, Zhang, Lijun, Swaminathan, S, Bischofberger, Norbert, Chen, Ming S, Mendel, Dirk B, Tai, Chun Y, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of the American Chemical Society (29.01.1997)
Published in Journal of the American Chemical Society (29.01.1997)
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