Evidence for C----Cl/C----Br···π Interactions as an Important Contribution to Protein-Ligand Binding Affinity
Matter, Hans, Nazaré, Marc, Güssregen, Stefan, Will, David W, Schreuder, Herman, Bauer, Armin, Urmann, Matthias, Ritter, Kurt, Wagner, Michael, Wehner, Volkmar
Published in Angewandte Chemie (International ed.) (06.04.2009)
Published in Angewandte Chemie (International ed.) (06.04.2009)
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Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2
La Venuta, Giuseppe, Wegehingel, Sabine, Sehr, Peter, Müller, Hans-Michael, Dimou, Eleni, Steringer, Julia P., Grotwinkel, Mareike, Hentze, Nikolai, Mayer, Matthias P., Will, David W., Uhrig, Ulrike, Lewis, Joe D., Nickel, Walter
Published in The Journal of biological chemistry (19.08.2016)
Published in The Journal of biological chemistry (19.08.2016)
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Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells
Karantzelis, Nikolaos, Petropoulos, Michalis, De Marco, Valeria, Egan, David A, Fish, Alexander, Christodoulou, Evangelos, Will, David W, Lewis, Joe D, Perrakis, Anastassis, Lygerou, Zoi, Taraviras, Stavros
Published in Frontiers in pharmacology (25.04.2022)
Published in Frontiers in pharmacology (25.04.2022)
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Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography
Nazaré, Marc, Will, David W, Matter, Hans, Schreuder, Herman, Ritter, Kurt, Urmann, Matthias, Essrich, Melanie, Bauer, Armin, Wagner, Michael, Czech, Jörg, Lorenz, Martin, Laux, Volker, Wehner, Volkmar
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Synthesis and Evaluation of Novel Ring‐Strained Noncanonical Amino Acids for Residue‐Specific Bioorthogonal Reactions in Living Cells
Reinkemeier, Christopher D., Koehler, Christine, Sauter, Paul F., Shymanska, Nataliia V., Echalier, Cecile, Rutkowska, Anna, Will, David W., Schultz, Carsten, Lemke, Edward A.
Published in Chemistry : a European journal (01.04.2021)
Published in Chemistry : a European journal (01.04.2021)
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Probing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands
Fernández-Bachiller, María Isabel, Hwang, Songhwan, Schembri, María Elena, Lindemann, Peter, Guberman, Mónica, Herziger, Svenja, Specker, Edgar, Matter, Hans, Will, David W., Czech, Jörg, Wagner, Michael, Bauer, Armin, Schreuder, Herman, Ritter, Kurt, Urmann, Matthias, Wehner, Volkmar, Sun, Han, Nazaré, Marc
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes
Nazaré, Marc, Matter, Hans, Will, David W., Wagner, Michael, Urmann, Matthias, Czech, Jörg, Schreuder, Herman, Bauer, Armin, Ritter, Kurt, Wehner, Volkmar
Published in Angewandte Chemie (International ed.) (23.01.2012)
Published in Angewandte Chemie (International ed.) (23.01.2012)
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PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties
Uhlmann, Eugen, Peyman, Anusch, Breipohl, Gerhard, Will, David W.
Published in Angewandte Chemie (International ed.) (02.11.1998)
Published in Angewandte Chemie (International ed.) (02.11.1998)
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A time‐resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling
Ahmed, Mennatallah, Legrand, Cyril, Yagüe Relimpio, Ana, Beretta, Carlo A., Muschko, Alina, Wegehingel, Sabine, Müller, Hans‐Michael, Sehr, Peter, Will, David W., Lewis, Joe D., Nickel, Walter
Published in FEBS letters (01.08.2019)
Published in FEBS letters (01.08.2019)
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Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa
Dickopf, Stefan, Frank, Michael, Junker, Hans-Dieter, Maier, Sabine, Metz, Günther, Ottleben, Holger, Rau, Harald, Schellhaas, Nathalie, Schmidt, Kristina, Sekul, Renate, Vanier, Cecile, Vetter, Dirk, Czech, Jörg, Lorenz, Martin, Matter, Hans, Schudok, Manfred, Schreuder, Herman, Will, David W., Nestler, Hans Peter
Published in Analytical biochemistry (01.12.2004)
Published in Analytical biochemistry (01.12.2004)
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Structural Requirements for Factor Xa Inhibition by 3-Oxybenzamides with Neutral P1 Substituents: Combining X-ray Crystallography, 3D-QSAR, and Tailored Scoring Functions
Matter, Hans, Will, David W, Nazaré, Marc, Schreuder, Herman, Laux, Volker, Wehner, Volkmar
Published in Journal of medicinal chemistry (05.05.2005)
Published in Journal of medicinal chemistry (05.05.2005)
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Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents
Nazaré, Marc, Essrich, Melanie, Will, David W, Matter, Hans, Ritter, Kurt, Urmann, Matthias, Bauer, Armin, Schreuder, Herman, Dudda, Angela, Czech, Jörg, Lorenz, Martin, Laux, Volker, Wehner, Volkmar
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy
Will, David W., Breipohl, Gerhard, Langner, Dietrich, Knolle, Jochen, Uhlmann, Eugen
Published in Tetrahedron (30.10.1995)
Published in Tetrahedron (30.10.1995)
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Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand
Nazaré, Marc, Essrich, Melanie, Will, David W, Matter, Hans, Ritter, Kurt, Urmann, Matthias, Bauer, Armin, Schreuder, Herman, Czech, Jörg, Lorenz, Martin, Laux, Volker, Wehner, Volkmar
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Journal Article
Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand
Nazaré, Marc, Matter, Hans, Klingler, Otmar, Al-Obeidi, Fahad, Schreuder, Herman, Zoller, Gerhard, Czech, Jörg, Lorenz, Martin, Dudda, Angela, Peyman, Anusch, Nestler, Hans Peter, Urmann, Matthias, Bauer, Armin, Laux, Volker, Wehner, Volkmar, Will, David W.
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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3‘-End Conjugates of Minimally Phosphorothioate-Protected Oligonucleotides with 1-O-Hexadecylglycerol: Synthesis and Anti-ras Activity in Radiation-Resistant Cells
Rait, Antonina, Pirollo, Kathleen, Will, David W, Peyman, Anush, Rait, Vladimir, Uhlmann, Eugen, Chang, Esther H
Published in Bioconjugate chemistry (01.03.2000)
Published in Bioconjugate chemistry (01.03.2000)
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αvβ3 antagonists based on a central thiophene scaffold
PEYMAN, Anusch, SCHEUNEMANN, Karl-Heinz, AUBERVAL, Marielle, DOUCET, Bernard, BARON, Roland, GAILLARD, Martine, GADEK, Thomas R, BODARY, Sarah, WILL, David W, KNOLLE, Jochen, WEHNER, Volkmar, BREIPOHL, Gerhard, STILZ, Hans Ulrich, CARNIATO, Denis, RUXER, Jean-Marie, GOURVEST, Jean-Francois
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
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Journal Article
Synthesis and properties of PNA/DNA chimeras
Uhlmann, E, Will, DW, Breipohl, G, Langner, D, Ryte, A
Published in Angewandte Chemie International Edition (01.12.1996)
Published in Angewandte Chemie International Edition (01.12.1996)
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Fragment Deconstruction of Small, Potent FactorXa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes
Nazare, Marc, Matter, Hans, Will, David W, Wagner, Michael, Urmann, Matthias, Czech, Jörg, Schreuder, Herman, Bauer, Armin, Ritter, Kurt, Wehner, Volkmar
Published in Angewandte Chemie International Edition (23.01.2012)
Published in Angewandte Chemie International Edition (23.01.2012)
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Inside Back Cover: Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes (Angew. Chem. Int. Ed. 4/2012)
Nazaré, Marc, Matter, Hans, Will, David W., Wagner, Michael, Urmann, Matthias, Czech, Jörg, Schreuder, Herman, Bauer, Armin, Ritter, Kurt, Wehner, Volkmar
Published in Angewandte Chemie (International ed.) (23.01.2012)
Published in Angewandte Chemie (International ed.) (23.01.2012)
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