Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel
Ekins, Sean, Crumb, William J, Sarazan, R Dustan, Wikel, James H, Wrighton, Steven A
Published in The Journal of pharmacology and experimental therapeutics (01.05.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2002)
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Journal Article
Influence of Molecular Structure on Substrate Binding to the Human Organic Cation Transporter, hOCT1
Bednarczyk, Dallas, Ekins, Sean, Wikel, James H, Wright, Stephen H
Published in Molecular pharmacology (01.03.2003)
Published in Molecular pharmacology (01.03.2003)
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Journal Article
Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates
Ekins, Sean, Kim, Richard B, Leake, Brenda F, Dantzig, Anne H, Schuetz, Erin G, Lan, Lu-Bin, Yasuda, Kazuto, Shepard, Robert L, Winter, Mark A, Schuetz, John D, Wikel, James H, Wrighton, Steven A
Published in Molecular pharmacology (01.05.2002)
Published in Molecular pharmacology (01.05.2002)
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Journal Article
Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein
Ekins, Sean, Kim, Richard B, Leake, Brenda F, Dantzig, Anne H, Schuetz, Erin G, Lan, Lu-Bin, Yasuda, Kazuto, Shepard, Robert L, Winter, Mark A, Schuetz, John D, Wikel, James H, Wrighton, Steven A
Published in Molecular pharmacology (01.05.2002)
Published in Molecular pharmacology (01.05.2002)
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Journal Article
Progress in predicting human ADME parameters in silico
Ekins, Sean, Waller, Chris L, Swaan, Peter W, Cruciani, Gabriele, Wrighton, Steven A, Wikel, James H
Published in Journal of pharmacological and toxicological methods (01.07.2000)
Published in Journal of pharmacological and toxicological methods (01.07.2000)
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Journal Article
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
Kelley, Mark R, Wikel, James H, Guo, Chunlu, Pollok, Karen E, Bailey, Barbara J, Wireman, Randy, Fishel, Melissa L, Vasko, Michael R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2016)
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Journal Article
Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization
Sardar Pasha, Sheik Pran Babu, Sishtla, Kamakshi, Sulaiman, Rania S, Park, Bomina, Shetty, Trupti, Shah, Fenil, Fishel, Melissa L, Wikel, James H, Kelley, Mark R, Corson, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
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Journal Article
Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis
Crumb, William J., Ekins, Sean, Sarazan, R. Dustan, Wikel, James H., Wrighton, Steven A., Carlson, Christopher, Beasley, Charles M.
Published in Pharmaceutical research (01.06.2006)
Published in Pharmaceutical research (01.06.2006)
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Journal Article
Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors
Ekins, S, Bravi, G, Binkley, S, Gillespie, J S, Ring, B J, Wikel, J H, Wrighton, S A
Published in The Journal of pharmacology and experimental therapeutics (01.07.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1999)
Journal Article
Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents
Lobb, Karen L, Hipskind, Philip A, Aikins, James A, Alvarez, Enrique, Cheung, Yiu-Yin, Considine, Eileen L, De Dios, Alfonso, Durst, Gregory L, Ferritto, Rafael, Grossman, Cora Sue, Giera, Deborah D, Hollister, Beth A, Huang, Zhongping, Iversen, Philip W, Law, Kevin L, Li, Tiechao, Lin, Ho-Shen, Lopez, Beatriz, Lopez, Jose E, Cabrejas, Luisa M. Martin, McCann, Denis J, Molero, Victoriano, Reilly, John E, Richett, Michael E, Shih, Chuan, Teicher, Beverly, Wikel, James H, White, Wesley T, Mader, Mary M
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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Journal Article
Three-Dimensional Quantitative Structure Activity Relationship Analyses of Substrates for CYP2B6
Ekins, S, Bravi, G, Ring, B J, Gillespie, T A, Gillespie, J S, Vandenbranden, M, Wrighton, S A, Wikel, J H
Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
Journal Article
Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models
Gampala, Silpa, Chowdhury, Nayela, Babb, Olivia, Caston, Rachel A., Wireman, Randall S., Moon, Hye-ran, Sandusky, George, Hulsey, Emily, Han, Bumsoo, Georgiadis, Millie M., Quinney, Sara K., Masters, Andi R., Wikel, James H., Kelley, Mark R., Fishel, Melissa L.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication
Ekins, Sean, Durst, Gregory L, Stratford, Robert E, Thorner, David A, Lewis, Richard, Loncharich, Richard J, Wikel, James H
Published in Journal of Chemical Information and Computer Sciences (01.11.2001)
Published in Journal of Chemical Information and Computer Sciences (01.11.2001)
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Journal Article
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex
McQuaid, Loretta A, Smith, Edward C. R, Lodge, David, Pralong, Etienne, Wikel, James H, Calligaro, David O, O'Malley, Patrick J
Published in Journal of medicinal chemistry (01.09.1992)
Published in Journal of medicinal chemistry (01.09.1992)
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Journal Article
Experimental Designs for Selecting Molecules from Large Chemical Databases
Higgs, Richard E, Bemis, Kerry G, Watson, Ian A, Wikel, James H
Published in Journal of Chemical Information and Computer Sciences (01.09.1997)
Published in Journal of Chemical Information and Computer Sciences (01.09.1997)
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Journal Article
Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia
Cardoso, Angelo A., Wikel, James H., Ding, Jixin, Reed, April M., Luo, Meihua, Kelley, Mark R.
Published in Cancer research (Chicago, Ill.) (15.10.2014)
Published in Cancer research (Chicago, Ill.) (15.10.2014)
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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists
Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (29.08.1997)
Published in Journal of medicinal chemistry (29.08.1997)
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Journal Article
Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds
Takeuchi, Kumiko, Kohn, Todd J, True, Timothy A, Mais, Dale E, Wikel, James H, Utterback, Barbara G, Wyss, Virginia L, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (31.12.1998)
Published in Journal of medicinal chemistry (31.12.1998)
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Journal Article