Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
da Silva Gonçalves Bós, Denielli, Van Der Bruggen, Cathelijne E E, Kurakula, Kondababu, Sun, Xiao-Qing, Casali, Karina R, Casali, Adenauer G, Rol, Nina, Szulcek, Robert, dos Remedios, Cris, Guignabert, Christophe, Tu, Ly, Dorfmüller, Peter, Humbert, Marc, Wijnker, Paul J.M, Kuster, Diederik W.D, van der Velden, Jolanda, Goumans, Marie-José, Bogaard, Harm-Jan, Vonk-Noordegraaf, Anton, de Man, Frances S, Handoko, M Louis
Published in Circulation (New York, N.Y.) (27.02.2018)
Published in Circulation (New York, N.Y.) (27.02.2018)
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Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue
Wijnker, Paul J.M, Friedrich, Felix W, Dutsch, Alexander, Reischmann, Silke, Eder, Alexandra, Vollert-Mannhardt, Ingra, Mearini, Giulia, Eschenhagen, Thomas, van der Velden, Jolanda, Carrier, Lucie
Published in Journal of molecular and cellular cardiology (01.08.2016)
Published in Journal of molecular and cellular cardiology (01.08.2016)
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Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations
Sequeira, Vasco, Wijnker, Paul J.M, Nijenkamp, Louise L.A.M, Kuster, Diederik W.D, Najafi, Aref, Witjas-Paalberends, E Rosalie, Regan, Jessica A, Boontje, Nicky, ten Cate, Folkert J, Germans, Tjeerd, Carrier, Lucie, Sadayappan, Sakthivel, van Slegtenhorst, Marjon A, Zaremba, Ruud, Foster, D Brian, Murphy, Anne M, Poggesi, Corrado, dos Remedios, Cris, Stienen, Ger J.M, Ho, Carolyn Y, Michels, Michelle, van der Velden, Jolanda
Published in Circulation research (24.05.2013)
Published in Circulation research (24.05.2013)
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Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice
Mearini, Giulia, Stimpel, Doreen, Geertz, Birgit, Weinberger, Florian, Krämer, Elisabeth, Schlossarek, Saskia, Mourot-Filiatre, Julia, Stoehr, Andrea, Dutsch, Alexander, Wijnker, Paul J. M., Braren, Ingke, Katus, Hugo A., Müller, Oliver J., Voit, Thomas, Eschenhagen, Thomas, Carrier, Lucie
Published in Nature communications (02.12.2014)
Published in Nature communications (02.12.2014)
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Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium–glucose cotransporter 2 inhibitors
Wijnker, Paul J M, Dinani, Rafeeh, van der Laan, Nico C, Algül, Sila, Knollmann, Bjorn C, Verkerk, Arie O, Remme, Carol Ann, Zuurbier, Coert J, Kuster, Diederik W D, van der Velden, Jolanda
Published in Cardiovascular research (14.03.2024)
Published in Cardiovascular research (14.03.2024)
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Translational investigation of electrophysiology in hypertrophic cardiomyopathy
Flenner, Frederik, Jungen, Christiane, Küpker, Nadine, Ibel, Antonia, Kruse, Martin, Koivumäki, Jussi T., Rinas, Anna, Zech, Antonia T.L., Rhoden, Alexandra, Wijnker, Paul J.M., Lemoine, Marc D., Steenpass, Anna, Girdauskas, Evaldas, Eschenhagen, Thomas, Meyer, Christian, van der Velden, Jolanda, Patten-Hamel, Monica, Christ, Torsten, Carrier, Lucie
Published in Journal of molecular and cellular cardiology (01.08.2021)
Published in Journal of molecular and cellular cardiology (01.08.2021)
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The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM
Piroddi, Nicoletta, Witjas-Paalberends, E Rosalie, Ferrara, Claudia, Ferrantini, Cecilia, Vitale, Giulia, Scellini, Beatrice, Wijnker, Paul J M, Sequiera, Vasco, Dooijes, Dennis, Dos Remedios, Cristobal, Schlossarek, Saskia, Leung, Man Ching, Messer, Andrew, Ward, Douglas G, Biggeri, Annibale, Tesi, Chiara, Carrier, Lucie, Redwood, Charles S, Marston, Steven B, van der Velden, Jolanda, Poggesi, Corrado
Published in The Journal of general physiology (07.01.2019)
Published in The Journal of general physiology (07.01.2019)
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ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease
Sequeira, Vasco, Najafi, Aref, Wijnker, Paul J. M., dos Remedios, Cristobal G., Michels, Michelle, Kuster, Diederik W. D., van der Velden, Jolanda
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
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Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
Buikema, Jan W., Lee, Soah, Goodyer, William R., Maas, Renee G., Chirikian, Orlando, Li, Guang, Miao, Yi, Paige, Sharon L., Lee, Daniel, Wu, Haodi, Paik, David T., Rhee, Siyeon, Tian, Lei, Galdos, Francisco X., Puluca, Nazan, Beyersdorf, Benjamin, Hu, James, Beck, Aimee, Venkamatran, Sneha, Swami, Srilatha, Wijnker, Paul, Schuldt, Maike, Dorsch, Larissa M., van Mil, Alain, Red-Horse, Kristy, Wu, Joy Y., Geisen, Caroline, Hesse, Michael, Serpooshan, Vahid, Jovinge, Stefan, Fleischmann, Bernd K., Doevendans, Pieter A., van der Velden, Jolanda, Garcia, K. Christopher, Wu, Joseph C., Sluijter, Joost P.G., Wu, Sean M.
Published in Cell stem cell (02.07.2020)
Published in Cell stem cell (02.07.2020)
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Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts
Karpus, Olga N, Heutinck, Kirstin M, Wijnker, Paul J M, Tak, Paul P, Hamann, Jörg
Published in PloS one (10.05.2012)
Published in PloS one (10.05.2012)
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S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure
Stathopoulou, Konstantina, Wittig, Ilka, Heidler, Juliana, Piasecki, Angelika, Richter, Florian, Diering, Simon, van der Velden, Jolanda, Buck, Friedrich, Donzelli, Sonia, Schröder, Ewald, Wijnker, Paul J M, Voigt, Niels, Dobrev, Dobromir, Sadayappan, Sakthivel, Eschenhagen, Thomas, Carrier, Lucie, Eaton, Philip, Cuello, Friederike
Published in The FASEB journal (01.05.2016)
Published in The FASEB journal (01.05.2016)
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Journal Article
Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue
Dutsch, Alexander, Wijnker, Paul J. M., Schlossarek, Saskia, Friedrich, Felix W., Krämer, Elisabeth, Braren, Ingke, Hirt, Marc N., Brenière-Letuffe, David, Rhoden, Alexandra, Mannhardt, Ingra, Eschenhagen, Thomas, Carrier, Lucie, Mearini, Giulia
Published in Scientific reports (03.12.2019)
Published in Scientific reports (03.12.2019)
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A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis
Wijnker, Paul J.M, Li, Yuejin, Zhang, Pingbo, Foster, D. Brian, Remedios, Cris dos, Van Eyk, Jennifer E, Stienen, Ger J.M, Murphy, Anne M, van der Velden, Jolanda
Published in Journal of molecular and cellular cardiology (01.05.2015)
Published in Journal of molecular and cellular cardiology (01.05.2015)
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Journal Article
Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation
Wijnker, Paul J M, Sequeira, Vasco, Foster, D Brian, Li, Yuejin, Dos Remedios, Cristobal G, Murphy, Anne M, Stienen, Ger J M, van der Velden, Jolanda
Published in American journal of physiology. Heart and circulatory physiology (15.04.2014)
Published in American journal of physiology. Heart and circulatory physiology (15.04.2014)
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PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis
Kooij, Viola, Zhang, Pingbo, Piersma, Sander R, Sequeira, Vasco, Boontje, Nicky M, Wijnker, Paul J M, Jiménez, Connie R, Jaquet, Kornelia E, dos Remedios, Cris, Murphy, Anne M, Van Eyk, Jennifer E, van der Velden, Jolanda, Stienen, Ger Jm
Published in PloS one (07.10.2013)
Published in PloS one (07.10.2013)
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Journal Article
GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human: Short Communication
Kuster, Diederik W D, Sequeira, Vasco, Najafi, Aref, Boontje, Nicky M, Wijnker, Paul J M, Witjas-Paalberends, E Rosalie, Marston, Steven B, dos Remedios, Cristobal G, Carrier, Lucie, Demmers, Jeroen A A, Redwood, Charles, Sadayappan, Sakthivel, van der Velden, Jolanda
Published in Circulation research (15.02.2013)
Published in Circulation research (15.02.2013)
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Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium
Wijnker, Paul J. M., Boknik, Peter, Gergs, Ulrich, Müller, Frank U., Neumann, Joachim, dos Remedios, Cris, Schmitz, Wilhelm, Sindermann, Jürgen R., Stienen, Ger J. M., van der Velden, Jolanda, Kirchhefer, Uwe
Published in Journal of muscle research and cell motility (01.11.2011)
Published in Journal of muscle research and cell motility (01.11.2011)
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Development of a 3-Dimensional Model to Study Right Heart Dysfunction in Pulmonary Arterial Hypertension: First Observations
Llucià-Valldeperas, Aida, Smal, Rowan, Bekedam, Fjodor T, Cé, Margaux, Pan, Xiaoke, Manz, Xue D, Wijnker, Paul J M, Vonk-Noordegraaf, Anton, Bogaard, Harm J, Goumans, Marie-Jose, Man, Frances S de
Published in Cells (Basel, Switzerland) (20.12.2021)
Published in Cells (Basel, Switzerland) (20.12.2021)
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