Non-communicable diseases among adolescents: current status, determinants, interventions and policies
Akseer, N, Mehta, S, Wigle, J, Chera, R, Brickman, Z J, Al-Gashm, S, Sorichetti, B, Vandermorris, A, Hipgrave, D B, Schwalbe, N, Bhutta, Z A
Published in BMC public health (14.12.2020)
Published in BMC public health (14.12.2020)
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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
Knutson, Sarah K, Kawano, Satoshi, Minoshima, Yukinori, Warholic, Natalie M, Huang, Kuan-Chun, Xiao, Yonghong, Kadowaki, Tadashi, Uesugi, Mai, Kuznetsov, Galina, Kumar, Namita, Wigle, Tim J, Klaus, Christine R, Allain, Christina J, Raimondi, Alejandra, Waters, Nigel J, Smith, Jesse J, Porter-Scott, Margaret, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A, Richon, Victoria M, Uenaka, Toshimitsu, Pollock, Roy M, Kuntz, Kevin W, Yokoi, Akira, Keilhack, Heike
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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Journal Article
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W
Published in Nature chemical biology (01.11.2012)
Published in Nature chemical biology (01.11.2012)
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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, DiMaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Published in Nature chemical biology (10.07.2011)
Published in Nature chemical biology (10.07.2011)
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Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction
Medwid, Samantha, Wigle, Theodore J, Ross, Cameron, Kim, Richard B
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Journal Article
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Kuntz, Kevin W, Campbell, John E, Keilhack, Heike, Pollock, Roy M, Knutson, Sarah K, Porter-Scott, Margaret, Richon, Victoria M, Sneeringer, Chris J, Wigle, Tim J, Allain, Christina J, Majer, Christina R, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Journal Article
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, Jeffrey T., Harvey, Natasha, Detmar, Michael, Lagutina, Irina, Grosveld, Gerard, Gunn, Michael D., Jackson, David G., Oliver, Guillermo
Published in The EMBO journal (01.04.2002)
Published in The EMBO journal (01.04.2002)
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Journal Article
DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report
Wigle, Theodore J, Tsvetkova, Elena V, Welch, Stephen A, Kim, Richard B
Published in Pharmaceutics (01.05.2019)
Published in Pharmaceutics (01.05.2019)
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Journal Article
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Knutson, Sarah K, Warholic, Natalie M, Johnston, L Danielle, Klaus, Christine R, Wigle, Tim J, Iwanowicz, Dorothy, Littlefield, Bruce A, Porter-Scott, Margaret, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Pollock, Roy M, Kuntz, Kevin W, Raimondi, Alejandra, Keilhack, Heike
Published in PloS one (10.12.2014)
Published in PloS one (10.12.2014)
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.
Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
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Journal Article
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines
Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Global positioning system and distress signal frequency wrist wearable dual‐band antenna
Alkhamis, R., Wigle, J., Song, H.
Published in Microwave and optical technology letters (01.08.2017)
Published in Microwave and optical technology letters (01.08.2017)
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Journal Article
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Wigle, Tim J., Knutson, Sarah K., Jin, Lei, Kuntz, Kevin W., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Scott, Margaret Porter
Published in FEBS letters (03.10.2011)
Published in FEBS letters (03.10.2011)
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Journal Article
Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events
Wigle, Theodore J., Povitz, Brandi L., Medwid, Samantha, Teft, Wendy A., Legan, Robin M., Lenehan, John, Nevison, Stephanie, Panuganty, Veera, Keller, Denise, Mailloux, Jaymie, Siebring, Victoria, Sarma, Sisira, Choi, Yun‐hee, Welch, Stephen, Winquist, Eric, Schwarz, Ute I., Kim, Richard B.
Published in Clinical and translational science (01.07.2021)
Published in Clinical and translational science (01.07.2021)
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Journal Article
Identification of a peptide inhibitor for the histone methyltransferase WHSC1
Morrison, Michael J, Boriack-Sjodin, P Ann, Swinger, Kerren K, Wigle, Tim J, Sadalge, Dipti, Kuntz, Kevin W, Scott, Margaret Porter, Janzen, William P, Chesworth, Richard, Duncan, Kenneth W, Harvey, Darren M, Lampe, John W, Mitchell, Lorna H, Copeland, Robert A
Published in PloS one (09.05.2018)
Published in PloS one (09.05.2018)
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Journal Article
Prox1 function is crucial for mouse lens-fibre elongation
Oliver, Guillermo, Wigle, Jeffrey T, Chowdhury, Kamal, Gruss, Peter
Published in Nature genetics (01.03.1999)
Published in Nature genetics (01.03.1999)
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Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
Kireev, Dmitri, Wigle, Tim J, Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P, Frye, Stephen V
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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