Discovery and Selection of TMC114, a Next Generation HIV-1 Protease Inhibitor
Surleraux, Dominique L. N. G, Tahri, Abdellah, Verschueren, Wim G, Pille, Geert M. E, de Kock, Herman A, Jonckers, Tim H. M, Peeters, Anik, De Meyer, Sandra, Azijn, Hilde, Pauwels, Rudi, de Bethune, Marie-Pierre, King, Nancy M, Prabu-Jeyabalan, Moses, Schiffer, Celia A, Wigerinck, Piet B. T. P
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates
DE MEYER, Sandra, AZIJN, Hilde, SURLERAUX, Dominique, JOCHMANS, Dirk, TAHRI, Abdellah, PAUWELS, Rudi, WIGERINCK, Piet, DE BETHUNE, Marie-Pierre
Published in Antimicrobial Agents and Chemotherapy (01.06.2005)
Published in Antimicrobial Agents and Chemotherapy (01.06.2005)
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Journal Article
Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor
KING, Nancy M, PRABU-JEYABALAN, Moses, NALIVAIKA, Ellen A, WIGERINCK, Piet, DE BETHUNE, Marie-Pierre, SCHIFFER, Celia A
Published in Journal of Virology (01.11.2004)
Published in Journal of Virology (01.11.2004)
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Journal Article
3295 RAPIDLY PROGRESSIVE AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE : RISK FACTORS FOR DISEASE SEVERITY DURING CHILDHOOD AND EARLY ADULTHOOD
Wigerinck, Stijn, Schellekens, Pieter, Dachy, Angélique, Chedid, Maroun, Hanna, Christian, Jouret, François, Harris, Peter, Bammens, Bert, Chebib, Fouad, Mekahli, Djalila
Published in Nephrology, dialysis, transplantation (14.06.2023)
Published in Nephrology, dialysis, transplantation (14.06.2023)
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Journal Article
In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
LIN, Tse-I, LENZ, Oliver, VRANG, Lotta, DE KOCK, Herman, WIGERINCK, Piet, RABOISSON, Pierre, SIMMEN, Kenneth, FANNING, Gregory, VERBINNEN, Thierry, DELOUVROY, Frédéric, SCHOLLIERS, Annick, VERMEIREN, Katrien, ROSENQUIST, Asa, EDLUND, Michael, SAMUELSSON, Bertil
Published in Antimicrobial Agents and Chemotherapy (01.04.2009)
Published in Antimicrobial Agents and Chemotherapy (01.04.2009)
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Journal Article
Stereoselective and Efficient Synthesis of (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol
Quaedflieg, Peter J. L. M, Kesteleyn, Bart R. R, Wigerinck, Piet B. T. P, Goyvaerts, Nicolaas M. F, Vijn, Robert Jan, Liebregts, Constantinus S. M, Kooistra, Jaap H. M. H, Cusan, Claudia
Published in Organic letters (22.12.2005)
Published in Organic letters (22.12.2005)
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Journal Article
Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase
Verschueren, Wim G, Dierynck, Inge, Amssoms, Katie I. E, Hu, Lili, Boonants, Paul M. J. G, Pille, Geert M. E, Daeyaert, Frits F. D, Hertogs, Kurt, Surleraux, Dominique L. N. G, Wigerinck, Piet B. T. P
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Design of HIV-1 Protease Inhibitors Active on Multidrug-Resistant Virus
Surleraux, Dominique L. N. G, de Kock, Herman A, Verschueren, Wim G, Pille, Geert M. E, Maes, Louis J. R, Peeters, Anik, Vendeville, Sandrine, De Meyer, Sandra, Azijn, Hilde, Pauwels, Rudi, de Bethune, Marie-Pierre, King, Nancy M, Prabu-Jeyabalan, Moses, Schiffer, Celia A, Wigerinck, Piet B. T. P
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Evaluation of Advanced MRI Cystic Biomarkers at Kidney Failure in Patients With Autosomal Dominant Polycystic Kidney Disease: TH-PO400
Wigerinck, Stijn, Chedid, Maroun, Gregory, Adriana, Kaidbay, Hasan-Daniel N., Hanna, Christian, Senum, Sarah R., Harris, Peter C., Kline, Timothy L., Torres, Vicente E., Chebib, Fouad T.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Journal Article
Cardiovascular Outcomes in Kidney Transplant Recipients With Autosomal Dominant Polycystic Kidney Disease: FR-PO851
Chedid, Maroun, Kaidbay, Hasan-Daniel N., Wigerinck, Stijn, Zubidat, Dalia, Reddy, Prajwal, Duriseti, Parikshit, Issa, Naim S., Zoghby, Ziad, Hanna, Christian, Senum, Sarah R., Harris, Peter C., Torres, Vicente E., Nkomo, Vuyisile T., Chebib, Fouad T.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Treatment innovation for patients: a collaborative network in the Benelux and an inside view of 20 years of Galapagos
Durez, Patrick, Hoekema, André, Huizinga, Tom, Gazin, Muriel, Present, Erik, Veelaert, Dirk, Wigerinck, Piet, Westhovens, René
Published in Acta clinica belgica (English ed. Online) (01.02.2022)
Published in Acta clinica belgica (English ed. Online) (01.02.2022)
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Journal Article
Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment
Baert, Lieven, van ‘t Klooster, Gerben, Dries, Willy, François, Marc, Wouters, Alfons, Basstanie, Esther, Iterbeke, Koen, Stappers, Fred, Stevens, Paul, Schueller, Laurent, Van Remoortere, Pieter, Kraus, Guenter, Wigerinck, Piet, Rosier, Jan
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2009)
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2009)
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Journal Article
Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350
Raboisson, Pierre, de Kock, Herman, Rosenquist, Åsa, Nilsson, Magnus, Salvador-Oden, Lourdes, Lin, Tse-I, Roue, Natalie, Ivanov, Vladimir, Wähling, Horst, Wickström, Kristina, Hamelink, Elizabeth, Edlund, Michael, Vrang, Lotta, Vendeville, Sandrine, Van de Vreken, Wim, McGowan, David, Tahri, Abdellah, Hu, Lili, Boutton, Carlo, Lenz, Oliver, Delouvroy, Frederic, Pille, Geert, Surleraux, Dominique, Wigerinck, Piet, Samuelsson, Bertil, Simmen, Kenneth
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Journal Article
Multicenter Real-Life Experience With Tolvaptan Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: TH-PO412
Duriseti, Parikshit, Wigerinck, Stijn, Chedid, Maroun, Radhakrishnan, Yeshwanter, Mao, Michael A., Hommos, Musab S., Garg, Arvind K., Zoghby, Ziad, Keddis, Mira T., Trautman, Christopher L., Dahlen, Erin, Gay, Melissa K., Mcfadden, Jennifer E., Bhat, Samrat V., Harris, Peter C., Erickson, Stephen B., Hogan, Marie C., Torres, Vicente E., Chebib, Fouad T.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
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Journal Article
Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action
JOCHMANS, Dirk, DEVAL, Jérome, EHTESHAMI, Maryam, WIGERINCK, Piet, GÖTTE, Matthias, HERTOGS, Kurt, KESTELEYN, Bart, VAN MARCK, Herwig, BETTENS, Eva, DE BAERE, Inky, DEHERTOGH, Pascale, IVENS, Tania, VAN GINDEREN, Marcia, VAN SCHOUBROECK, Bertrand
Published in Journal of Virology (01.12.2006)
Published in Journal of Virology (01.12.2006)
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Journal Article
Evaluation of advanced imaging biomarkers at kidney failure in patients with ADPKD: a pilot study
Wigerinck, Stijn, Gregory, Adriana V, Smith, Byron H, Iliuta, Loan-Andrei, Hanna, Christian, Chedid, Maroun, Kaidbay, Hasan-Daniel N, Senum, Sarah R, Shukoor, Shebaz, Harris, Peter C, Torres, Vicente E, Kline, Timothy L, Chebib, Fouad T
Published in Clinical kidney journal (01.10.2023)
Published in Clinical kidney journal (01.10.2023)
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Journal Article
OP0263 Efficacy and safety of GLPG0634, a selective JAK1 inhibitor, after short-term treatment of rheumatoid arthritis; results of a phase IIA trial
Vanhoutte, F.P., Mazur, M., Namour, F., van der Aa, A., Wigerinck, P., van ’t Klooster, G.A.E.
Published in Annals of the rheumatic diseases (01.06.2013)
Published in Annals of the rheumatic diseases (01.06.2013)
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Journal Article
Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1
Guillemont, Jerome, Pasquier, Elisabeth, Palandjian, Patrice, Vernier, Daniel, Gaurrand, Sandrine, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten H, Arnold, Eddy, Das, Kalyan, Pauwels, Rudi, Andries, Koen, de Béthune, Marie-Pierre, Bettens, Eva, Hertogs, Kurt, Wigerinck, Piet, Timmerman, Philip, Janssen, Paul A. J
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Evaluation of advanced imaging biomarkers at kidney failure in patients with ADPKD: a pilot study
Wigerinck, Stijn, Gregory, Adriana V, Smith, Byron H, Iliuta, Ioan-Andrei, Hanna, Christian, Chedid, Maroun, Kaidbay, Hasan-Daniel N, Senum, Sarah R, Shukoor, Shebaz, Harris, Peter C, Torres, Vicente E, Kline, Timothy L, Chebib, Fouad T
Published in Clinical kidney journal (01.10.2023)
Published in Clinical kidney journal (01.10.2023)
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Journal Article