Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology
Wiersma, Vera I., van Ziel, Anna Maria, Vazquez-Sanchez, Sonia, Nölle, Anna, Berenjeno-Correa, Ernesto, Bonaterra-Pastra, Anna, Clavaguera, Florence, Tolnay, Markus, Musters, René J. P., van Weering, Jan R. T., Verhage, Matthijs, Hoozemans, Jeroen J. M., Scheper, Wiep
Published in Acta neuropathologica (01.12.2019)
Published in Acta neuropathologica (01.12.2019)
Get full text
Journal Article
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
Hruska-Plochan, Marian, Wiersma, Vera I, Betz, Katharina M, Mallona, Izaskun, Ronchi, Silvia, Maniecka, Zuzanna, Hock, Eva-Maria, Tantardini, Elena, Laferriere, Florent, Sahadevan, Sonu, Hoop, Vanessa, Delvendahl, Igor, Pérez-Berlanga, Manuela, Gatta, Beatrice, Panatta, Martina, van der Bourg, Alexander, Bohaciakova, Dasa, Sharma, Puneet, De Vos, Laura, Frontzek, Karl, Aguzzi, Adriano, Lashley, Tammaryn, Robinson, Mark D, Karayannis, Theofanis, Mueller, Martin, Hierlemann, Andreas, Polymenidou, Magdalini
Published in Nature (London) (29.02.2024)
Published in Nature (London) (29.02.2024)
Get full text
Journal Article
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns
Pérez‐Berlanga, Manuela, Wiersma, Vera I, Zbinden, Aurélie, De Vos, Laura, Wagner, Ulrich, Foglieni, Chiara, Mallona, Izaskun, Betz, Katharina M, Cléry, Antoine, Weber, Julien, Guo, Zhongning, Rigort, Ruben, Rossi, Pierre, Manglunia, Ruchi, Tantardini, Elena, Sahadevan, Sonu, Stach, Oliver, Hruska‐Plochan, Marian, Allain, Frederic H‐T, Paganetti, Paolo, Polymenidou, Magdalini
Published in The EMBO journal (04.09.2023)
Published in The EMBO journal (04.09.2023)
Get full text
Journal Article
FTLD‐TDP assemblies seed neoaggregates with subtype‐specific features via a prion‐like cascade
De Rossi, Pierre, Lewis, Amanda J, Furrer, Johanna, De Vos, Laura, Demeter, Tomas, Zbinden, Aurélie, Zhong, Weijia, Wiersma, Vera I, Scialo, Carlo, Weber, Julien, Guo, Zhongning, Scaramuzza, Stefano, Di Fabrizio, Marta, Böing, Carolin, Castaño‐Díez, Daniel, Al‐Amoudi, Ashraf, Pérez‐Berlanga, Manuela, Lashley, Tammaryn, Stahlberg, Henning, Polymenidou, Magdalini
Published in EMBO reports (06.12.2021)
Published in EMBO reports (06.12.2021)
Get full text
Journal Article
Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology
Wiersma, Vera I, van Hecke, Wim, Scheper, Wiep, van Osch, Martijn A J, Hermsen, Will J M, Rozemuller, Annemieke J M, Hoozemans, Jeroen J M
Published in Acta neuropathologica communications (28.10.2016)
Published in Acta neuropathologica communications (28.10.2016)
Get full text
Journal Article
The seeding of tau pathology alters the endolysosomal system: Molecular and cell biology/endosomal‐lysosomal dysfunction
Vazquez‐Sanchez, Sonia, Wiersma, Vera I., Kole, Jeroen, Jongeneel, Rozemarijn, van Beek, Roderick, Bebelman, Maarten, Scheper, Wiep, van Weering, Jan
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
The seeding of tau pathology alters the endolysosomal system
Vazquez‐Sanchez, Sonia, Wiersma, Vera I., Kole, Jeroen, Jongeneel, Rozemarijn, van Beek, Roderick, Bebelman, Maarten, Scheper, Wiep, van Weering, Jan
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
Neuron‐selective induction of granulovacuolar degeneration bodies: A lysosomal stress response to tau aggregation?: Molecular and cell biology: Endo‐lysosomal/trafficking dysfunction
Wiersma, Vera I., van Ziel, Marieke, Vazquez‐Sanchez, Sonia, Nölle, Anna, Berenjeno‐Correa, Ernesto, Bonaterra‐Pastra, Anna, Clavaguera, Florence, van Weering, Jan, Verhage, Matthijs, Hoozemans, Jeroen J.M., Scheper, Wiep
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
Neuron‐selective induction of granulovacuolar degeneration bodies: A lysosomal stress response to tau aggregation?
Wiersma, Vera I., van Ziel, Marieke, Vazquez‐Sanchez, Sonia, Nölle, Anna, Berenjeno‐Correa, Ernesto, Bonaterra‐Pastra, Anna, Clavaguera, Florence, van Weering, Jan, Verhage, Matthijs, Hoozemans, Jeroen J.M., Scheper, Wiep
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
Pérez-Berlanga, Manuela, Wiersma, Vera I, Zbinden, Aurélie, De Vos, Laura, Wagner, Ulrich, Foglieni, Chiara, Mallona, Izaskun, Betz, Katharina M, Cléry, Antoine, Weber, Julien, Guo, Zhongning, Rigort, Ruben, De Rossi, Pierre, Manglunia, Ruchi, Tantardini, Elena, Sahadevan, Sonu, Stach, Oliver, Hruska-Plochan, Marian, Allain, Frederic H-T, Paganetti, Paolo, Polymenidou, Magdalini
Published in bioRxiv (25.05.2022)
Published in bioRxiv (25.05.2022)
Get full text
Paper
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
Hruska-Plochan, Marian, Hembach, Katharina M, Ronchi, Silvia, Wiersma, Vera I, Maniecka, Zuzanna, Hock, Eva-Maria, Laferriere, Florent, Sahadevan, Sonu, Hoop, Vanessa, Delvendahl, Igor, Panatta, Martina, Van Der Bourg, Alexander, Bohaciakova, Dasa, Frontzek, Karl, Aguzzi, Adriano, Lashley, Tammaryn, Robinson, Mark D, Karayannis, Theofanis, Mueller, Martin, Hierlemann, Andreas, Polymenidou, Magdalini
Published in bioRxiv (09.12.2021)
Published in bioRxiv (09.12.2021)
Get full text
Paper