Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+ Hematopoietic Stem‐Progenitor Cells
Gomez‐Puerto, Maria Catalina, Folkerts, Hendrik, Wierenga, Albertus T.J., Schepers, Koen, Schuringa, Jan Jacob, Coffer, Paul J., Vellenga, Edo
Published in Stem cells (Dayton, Ohio) (01.06.2016)
Published in Stem cells (Dayton, Ohio) (01.06.2016)
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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs
Mandoli, Amit, Singh, Abhishek A., Prange, Koen H.M., Tijchon, Esther, Oerlemans, Marjolein, Dirks, Rene, Ter Huurne, Menno, Wierenga, Albertus T.J., Janssen-Megens, Eva M., Berentsen, Kim, Sharifi, Nilofar, Kim, Bowon, Matarese, Filomena, Nguyen, Luan N., Hubner, Nina C., Rao, Nagesha A., van den Akker, Emile, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.
Published in Cell reports (Cambridge) (15.11.2016)
Published in Cell reports (Cambridge) (15.11.2016)
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STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells
Schepers, Hein, Wierenga, Albertus T.J., Vellenga, Edo, Schuringa, Jan Jacob
Published in JAK-STAT (01.01.2012)
Published in JAK-STAT (01.01.2012)
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Putative Autophagy Protein VMP1 Amplifies Protective Autophagy Under Stress Conditions in AML Cells
Folkerts, Hendrik, Wierenga, Albertus T.J., Schuringa, Jan Jacob, Vellenga, Edo
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Full Spectrum 40-Parameter Single-Tube Flow Cytometry Analysis for Longitudinal Immunophenotyping and Tracing of Clonal Heterogeneity in AML
Van Der Meer, Nisha K., Minh, Duy le, Pereira-Martins, Diego, Kleftogiannis, Dimitrios, Wierenga, Albertus T.J., Meijer, Kees, Mulder, Andre B., Huls, Gerwin A., Schuringa, Jan Jacob
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Dietary methionine starvation impairs acute myeloid leukemia progression
Cunningham, Alan, Erdem, Ayşegül, Alshamleh, Islam, Geugien, Marjan, Pruis, Maurien, Pereira-Martins, Diego Antonio, van den Heuvel, Fiona A. J., Wierenga, Albertus T. J., ten Berge, Hilde, Dennebos, Robin, van den Boom, Vincent, Hogeling, Shanna M., Weinhäuser, Isabel, Knops, Ruth, de Blaauw, Pim, Heiner-Fokkema, M. Rebecca, Woolthuis, Carolien, Günther, Ulrich L., Rego, Eduardo M., Martens, Joost H. A., Jansen, Joop H., Schwalbe, Harald, Huls, Gerwin, Schuringa, Jan Jacob
Published in Blood (10.11.2022)
Published in Blood (10.11.2022)
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Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability
Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Geugien, Marjan, Cunningham, Alan, Pruis, Maurien G., Weinhäuser, Isabel, Gerding, Albert, Bakker, Barbara M., Wierenga, Albertus T. J., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob
Published in Nature communications (19.04.2022)
Published in Nature communications (19.04.2022)
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Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients
Alheraky, Abdulrazzaq, Wierenga, Albertus T J, Simpelaar, Arjan, Hesp, Lucy B, Minovic, Isidor, Bagheri, Niusha, Roozendaal, Caroline, Span, Lambert F R, Oude Elberink, Hanneke N G, Kema, Ido P, Mulder, André B
Published in Clinical chemistry (Baltimore, Md.) (07.02.2024)
Published in Clinical chemistry (Baltimore, Md.) (07.02.2024)
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Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia
Folkerts, Hendrik, Hilgendorf, Susan, Wierenga, Albertus T J, Jaques, Jennifer, Mulder, André B, Coffer, Paul J, Schuringa, Jan Jacob, Vellenga, Edo
Published in Cell death & disease (13.07.2017)
Published in Cell death & disease (13.07.2017)
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Presence of mutant p53 increases stem cell frequency and is associated with reduced binding to classic TP53 binding sites in cell lines and primary AMLs
Gerritsen, Mylène, Hilgendorf, Susan, Yi, Guoqiang, Wierenga, Albertus T.J., Schuringa, Jan-Jacob, Martens, Joost H.A., Vellenga, Edo
Published in Experimental hematology (01.06.2022)
Published in Experimental hematology (01.06.2022)
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The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia
Erdem, Ayşegül, Marin, Silvia, Pereira-Martins, Diego A., Cortés, Roldán, Cunningham, Alan, Pruis, Maurien G., de Boer, Bauke, van den Heuvel, Fiona A. J., Geugien, Marjan, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Rego, Eduardo M., Huls, Gerwin, Cascante, Marta, Schuringa, Jan Jacob
Published in Nature communications (01.03.2022)
Published in Nature communications (01.03.2022)
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Proteolytic degradation of Smad4 in extracts of AML blasts
Wierenga, Albertus T.J, Eggen, Bart J.L, Kruijer, Wiebe, Vellenga, Edo
Published in Leukemia research (01.12.2002)
Published in Leukemia research (01.12.2002)
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The nonessential amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia
Cunningham, Alan, Oudejans, Lieve L, Geugien, Marjan, Pereira-Martins, Diego Antonio, Wierenga, Albertus T J, Erdem, Ayşegül, Sternadt, Dominique, Huls, Gerwin, Schuringa, Jan Jacob
Published in Blood advances (09.01.2024)
Published in Blood advances (09.01.2024)
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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes
Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.
Published in Cell reports (Cambridge) (22.01.2019)
Published in Cell reports (Cambridge) (22.01.2019)
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Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity Levels
Wierenga, Albertus T. J., Vellenga, Edo, Schuringa, Jan Jacob
Published in Molecular and Cellular Biology (01.11.2008)
Published in Molecular and Cellular Biology (01.11.2008)
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Identification of HIF2α as an important STAT5 target gene in human hematopoietic stem cells
Fatrai, Szabolcs, Wierenga, Albertus T.J., Daenen, Simon M.G.J., Vellenga, Edo, Schuringa, Jan Jacob
Published in Blood (24.03.2011)
Published in Blood (24.03.2011)
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Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation
Sontakke, Pallavi, Koczula, Katarzyna M, Jaques, Jennifer, Wierenga, Albertus T J, Brouwers-Vos, Annet Z, Pruis, Maurien, Günther, Ulrich L, Vellenga, Edo, Schuringa, Jan Jacob
Published in PloS one (07.04.2016)
Published in PloS one (07.04.2016)
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