Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation
Wiebe, John P., Pawlak, Kevin J., Kwok, Arthur
Published in The Journal of steroid biochemistry and molecular biology (01.01.2016)
Published in The Journal of steroid biochemistry and molecular biology (01.01.2016)
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Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride
Wiebe, John P., Rivas, Martin A., Mercogliano, Maria F., Elizalde, Patricia V., Schillaci, Roxana
Published in The Journal of steroid biochemistry and molecular biology (01.05.2015)
Published in The Journal of steroid biochemistry and molecular biology (01.05.2015)
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Decreased cytochrome c oxidase IV expression reduces steroidogenesis
Pawlak, Kevin J, Prasad, Manoj, McKenzie, Kevin A, Wiebe, John P, Gairola, C Gary, Whittal, Randy M, Bose, Himangshu S
Published in The Journal of pharmacology and experimental therapeutics (01.08.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2011)
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Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP) and 3α-dihydroprogesterone (3αHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines
Wiebe, John P., Beausoleil, Michel, Zhang, Guihua, Cialacu, Valentin
Published in The Journal of steroid biochemistry and molecular biology (2010)
Published in The Journal of steroid biochemistry and molecular biology (2010)
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Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP) and 3α-dihydroprogesterone (3αHP) on mitosis, apoptosis, and expression of Bc1-2, Bax and p21 in human breast cell lines
WIEBE, John P, BEAUSOLEIL, Michel, GUIHUA ZHANG, CIALACU, Valentin
Published in The Journal of steroid biochemistry and molecular biology (2010)
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Published in The Journal of steroid biochemistry and molecular biology (2010)
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The 4-pregnene and 5α-pregnane progesterone metabolites formed in nontumorous and tumorous breast tissue have opposite effects on breast cell proliferation and adhesion
WIEBE, J. P, MUZIA, D, JUNCAI HU, SZWAJCER, D, HILL, S. A, SEACHRIST, J. L
Published in Cancer research (Chicago, Ill.) (15.02.2000)
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Published in Cancer research (Chicago, Ill.) (15.02.2000)
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Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells
Weiler, Peter J., Wiebe, John P.
Published in Biochemical and biophysical research communications (16.06.2000)
Published in Biochemical and biophysical research communications (16.06.2000)
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De novo synthesis of steroids (from acetate) by isolated rat Sertoli cells
Wiebe, John P., Tilbe, Kim S.
Published in Biochemical and biophysical research communications (28.08.1979)
Published in Biochemical and biophysical research communications (28.08.1979)
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