Aberrantly activated anti‐apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets
Gitendra Wickremasinghe, R., Prentice, Archibald G., Steele, Andrew J.
Published in British journal of haematology (01.06.2011)
Published in British journal of haematology (01.06.2011)
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The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment
Steele, Andrew J., Prentice, Archibald G., Cwynarski, Kate, Hoffbrand, A. Victor, Hart, Stephen M., Lowdell, Mark W., Samuel, Edward R., Wickremasinghe, R. Gitendra
Published in Blood (25.11.2010)
Published in Blood (25.11.2010)
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2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells
Steele, Andrew J., Prentice, Archibald G., Hoffbrand, A. Victor, Yogashangary, Birunthini C., Hart, Stephen M., Lowdell, Mark W., Samuel, Edward R., North, Janet M., Nacheva, Elisabeth P., Chanalaris, Anastasios, Kottaridis, Panagiotis, Cwynarski, Kate, Wickremasinghe, R. Gitendra
Published in Blood (06.08.2009)
Published in Blood (06.08.2009)
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p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism
Steele, Andrew J., Prentice, Archibald G., Hoffbrand, A. Victor, Yogashangary, Birunthini C., Hart, Stephen M., Nacheva, Elisabeth P., Howard-Reeves, Julie D., Duke, Veronique M., Kottaridis, Panagiotis D., Cwynarski, Kate, Vassilev, Lyubomir T., Wickremasinghe, R. Gitendra
Published in Blood (01.11.2008)
Published in Blood (01.11.2008)
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Selective apoptotic killing of malignant hemopoietic cells by antibody-targeted delivery of an amphipathic peptide
MARKS, Alexandra J, COOPER, Margaret S, GITENDRA WICKREMASINGHE, R, ANDERSON, Robert J, ORCHARD, Kim H, HALE, Geoffrey, NORTH, Janet M, GANESHAGURU, Kanagasabai, STEELE, Andrew J, MEHTA, Atul B, LOWDELL, Mark W
Published in Cancer research (Chicago, Ill.) (15.03.2005)
Published in Cancer research (Chicago, Ill.) (15.03.2005)
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Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis
Jones, Dylan T., Ganeshaguru, Kanagasabai, Anderson, Robert J., Jackson, Trevor R., Bruckdorfer, K. Richard, Low, Sylvia Y., Palmqvist, Lars, Prentice, H. Grant, Hoffbrand, A. Victor, Mehta, Atul B., Wickremasinghe, R. Gitendra
Published in Blood (15.04.2003)
Published in Blood (15.04.2003)
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Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
MENGUBAS, K, RIORDAN, F. A, BRAVERY, C. A, LEWIN, J, OWENS, D. L, MEHTA, A. B, HOFFBRAND, A. V, GITENDRA WICKREMASINGHE, R
Published in Oncogene (15.04.1999)
Published in Oncogene (15.04.1999)
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Differential Cytopathology and Kinetics of Measles Oncolysis in Two Primary B-cell Malignancies Provides Mechanistic Insights
Patel, Bella, Dey, Aditi, Ghorani, Ehsan, Kumar, Shaji, Malam, Yogeshkumar, Rai, Lena, Steele, Andrew J, Thomson, Jennifer, Wickremasinghe, R Gitendra, Zhang, Yu, Castleton, Anna Z, Fielding, Adele K
Published in Molecular therapy (01.06.2011)
Published in Molecular therapy (01.06.2011)
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Ligation of CD8α on human natural killer cells prevents activation‐induced apoptosis and enhances cytolytic activity
Addison, Elena G., North, Janet, Bakhsh, Ismail, Marden, Chloe, Haq, Sumaira, Al‐Sarraj, Samia, Malayeri, Reza, Wickremasinghe, R. Gitendra, Davies, Jeffrey K., Lowdell, Mark W.
Published in Immunology (01.11.2005)
Published in Immunology (01.11.2005)
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Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells
RIORDAN, F. A, BRAVERY, C. A, MENGUBAS, K, RAY, N, BORTHWICK, N. J, AKBAR, A. N, HART, S. M, HOFFBRAND, A. V, MEHTA, A. B, WICKREMASINGHE, R. G
Published in Oncogene (26.03.1998)
Published in Oncogene (26.03.1998)
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Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs
Jones, Dylan T., Addison, Elena, North, Janet M., Lowdell, Mark W., Hoffbrand, A. Victor, Mehta, Atul B., Ganeshaguru, Kanagasabai, Folarin, Najeem I., Wickremasinghe, R. Gitendra
Published in Blood (01.03.2004)
Published in Blood (01.03.2004)
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Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation
Jones, Dylan T., Ganeshaguru, Kanagasabai, Virchis, Andres E., Folarin, Najeem I., Lowdell, Mark W., Mehta, Atul B., Prentice, H. Grant, Hoffbrand, A. Victor, Wickremasinghe, R. Gitendra
Published in Blood (01.11.2001)
Published in Blood (01.11.2001)
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Cytotoxic drugs enhance the ex vivo sensitivity of malignant cells from a subset of acute myeloid leukaemia patients to apoptosis induction by tumour necrosis factor receptor‐related apoptosis‐inducing ligand
Jones, Dylan T., Ganeshaguru, Kanagasabai, Mitchell, Wayne A., Foroni, Letizia, Baker, Robert J., Prentice, H. Grant, Mehta, Atul B., Wickremasinghe, R. Gitendra
Published in British journal of haematology (01.06.2003)
Published in British journal of haematology (01.06.2003)
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Monocytes Stimulate Expression of the Bcl-2 Family Member, A1, in Endothelial Cells and Confer Protection Against Apoptosis
Noble, Karen E, Wickremasinghe, R. Gitendra, DeCornet, Chris, Panayiotidis, Panayiotis, Yong, Kwee L
Published in The Journal of immunology (1950) (01.02.1999)
Published in The Journal of immunology (1950) (01.02.1999)
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Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage‐induced apoptosis in B‐chronic lymphocytic leukaemia cells
Wickremasinghe, R. Gitendra, Ganeshaguru, Kanagasabai, Jones, Dylan T., Lindsay, Caroline, Spanswick, Victoria J., Hartley, John A., Wadhwa, Meenu, Thorpe, Robin, Hoffbrand, A. Victor, Prentice, H. Grant, Mehta, Atul B.
Published in British journal of haematology (01.09.2001)
Published in British journal of haematology (01.09.2001)
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Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL60 promyelocytic leukaemia cell line
Mengubas, Kamuran, Riordan, Fiona A., Victor Hoffbrand, A., Gitendra Wickremasinghe, R.
Published in FEBS letters (07.10.1996)
Published in FEBS letters (07.10.1996)
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Regulation of transcription factors NF kappa B and AP-1 following tumour necrosis factor-alpha treatment of cells from chronic B cell leukaemia patients
Jabbar, S A, Hoffbrand, A V, Gitendra Wickremasinghe, R
Published in British journal of haematology (01.03.1994)
Published in British journal of haematology (01.03.1994)
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Phenethyl Isothiocyanate (PEITC) Regulates Autophagy in Chronic Lymphocytic Leukemia
Adams, Jemimah, Wickremasinghe, R Gitendra, Prentice, Archibald G, Strefford, Jonathan C., Duncombe, Andrew, Forconi, Francesco, Stevenson, Freda K., Packham, Graham, Steele, Andrew
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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