Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
Trzupek, Dominik, Dunstan, Melanie, Cutler, Antony J, Lee, Mercede, Godfrey, Leila, Jarvis, Lorna, Rainbow, Daniel B, Aschenbrenner, Dominik, Jones, Joanne L, Uhlig, Holm H, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Genome medicine (24.06.2020)
Published in Genome medicine (24.06.2020)
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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara M D, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles J M, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L, Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian P, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank
Published in PLoS medicine (11.10.2016)
Published in PLoS medicine (11.10.2016)
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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Asimit, Jennifer L., Rainbow, Daniel B., Fortune, Mary D., Grinberg, Nastasiya F., Wicker, Linda S., Wallace, Chris
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Burren, Oliver S, Rubio García, Arcadio, Javierre, Biola-Maria, Rainbow, Daniel B, Cairns, Jonathan, Cooper, Nicholas J, Lambourne, John J, Schofield, Ellen, Castro Dopico, Xaquin, Ferreira, Ricardo C, Coulson, Richard, Burden, Frances, Rowlston, Sophia P, Downes, Kate, Wingett, Steven W, Frontini, Mattia, Ouwehand, Willem H, Fraser, Peter, Spivakov, Mikhail, Todd, John A, Wicker, Linda S, Cutler, Antony J, Wallace, Chris
Published in Genome Biology (04.09.2017)
Published in Genome Biology (04.09.2017)
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Journal Article
SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile
Zhang, Jia-Yuan, Whalley, Justin P, Knight, Julian C, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Genome medicine (12.09.2023)
Published in Genome medicine (12.09.2023)
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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes
Kochupurakkal, Nora M, Kruger, Annie J, Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B, Rossini, Aldo, Greiner, Dale L, Sayegh, Mohamed H, Wicker, Linda S, Guleria, Indira
Published in PloS one (28.02.2014)
Published in PloS one (28.02.2014)
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Journal Article
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Published in Nature communications (28.11.2022)
Published in Nature communications (28.11.2022)
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Journal Article
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Bailey, Rebecca, Smyth, Deborah J, Atkinson, Mark, Plagnol, Vincent, Brusko, Todd, Lowe, Christopher E, Field, Sarah, Wicker, Linda S, Bourget, Kirsi, Walker, Neil M, Todd, John A, Clayton, David G, Cooper, Jason D
Published in Nature genetics (01.09.2007)
Published in Nature genetics (01.09.2007)
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Journal Article
The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus
Oliveira, João J, Karrar, Sarah, Rainbow, Daniel B, Pinder, Christopher L, Clarke, Pamela, Rubio García, Arcadio, Al-Assar, Osama, Burling, Keith, Morris, Sian, Stratton, Richard, Vyse, Tim J, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Arthritis research & therapy (27.07.2018)
Published in Arthritis research & therapy (27.07.2018)
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Journal Article
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S
Published in PLoS genetics (01.06.2015)
Published in PLoS genetics (01.06.2015)
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Journal Article
Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice
Mattner, Jochen, Mohammed, Javid P, Fusakio, Michael E, Giessler, Claudia, Hackstein, Carl-Philipp, Opoka, Robert, Wrage, Marius, Schey, Regina, Clark, Jan, Fraser, Heather I, Rainbow, Daniel B, Wicker, Linda S
Published in PLoS genetics (01.06.2019)
Published in PLoS genetics (01.06.2019)
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Journal Article
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles
Esposito, Laura, Hunter, Kara M D, Clark, Jan, Rainbow, Daniel B, Stevens, Helen, Denesha, Jennifer, Duley, Simon, Dawson, Sarah, Coleman, Gillian, Nutland, Sarah, Bell, Gwynneth L, Moran, Carla, Pekalski, Marcin, Todd, John A, Wicker, Linda S
Published in The Journal of immunology (1950) (15.07.2014)
Published in The Journal of immunology (1950) (15.07.2014)
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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., Jones, Joanne L.
Published in Communications biology (14.10.2021)
Published in Communications biology (14.10.2021)
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Journal Article
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus
Trzupek, Dominik, Lee, Mercede, Hamey, Fiona, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Wellcome open research (2021)
Published in Wellcome open research (2021)
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Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
Pekalski, Marcin L, García, Arcadio Rubio, Ferreira, Ricardo C, Rainbow, Daniel B, Smyth, Deborah J, Mashar, Meghavi, Brady, Jane, Savinykh, Natalia, Dopico, Xaquin Castro, Mahmood, Sumiyya, Duley, Simon, Stevens, Helen E, Walker, Neil M, Cutler, Antony J, Waldron-Lynch, Frank, Dunger, David B, Shannon-Lowe, Claire, Coles, Alasdair J, Jones, Joanne L, Wallace, Chris, Todd, John A, Wicker, Linda S
Published in JCI insight (17.08.2017)
Published in JCI insight (17.08.2017)
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Journal Article
Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models
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Book Review
Journal Article
Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus
Trzupek, Dominik, Lee, Mercede, Hamey, Fiona, Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Published in Wellcome open research (01.01.2021)
Published in Wellcome open research (01.01.2021)
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Journal Article
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression
Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.
Published in Frontiers in immunology (08.11.2019)
Published in Frontiers in immunology (08.11.2019)
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Journal Article
Allelic variant in CTLA4 alters T cell phosphorylation patterns
Maier, Lisa M, Anderson, David E, De Jager, Philip L, Wicker, Linda S, Hafler, David A
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2007)
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