Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara M D, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles J M, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L, Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian P, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank
Published in PLoS medicine (11.10.2016)
Published in PLoS medicine (11.10.2016)
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.
Published in Journal of autoimmunity (01.12.2018)
Published in Journal of autoimmunity (01.12.2018)
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Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells
Inshaw, Jamie R J, Cutler, Antony J, Crouch, Daniel J M, Wicker, Linda S, Todd, John A
Published in Diabetes care (01.01.2020)
Published in Diabetes care (01.01.2020)
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Robertson, Catherine C., Inshaw, Jamie R. J., Onengut-Gumuscu, Suna, Chen, Wei-Min, Santa Cruz, David Flores, Yang, Hanzhi, Cutler, Antony J., Crouch, Daniel J. M., Farber, Emily, Bridges, S. Louis, Edberg, Jeffrey C., Kimberly, Robert P., Buckner, Jane H., Deloukas, Panos, Divers, Jasmin, Dabelea, Dana, Lawrence, Jean M., Marcovina, Santica, Shah, Amy S., Greenbaum, Carla J., Atkinson, Mark A., Gregersen, Peter K., Oksenberg, Jorge R., Pociot, Flemming, Rewers, Marian J., Steck, Andrea K., Dunger, David B., Wicker, Linda S., Concannon, Patrick, Todd, John A., Rich, Stephen S.
Published in Nature genetics (01.07.2021)
Published in Nature genetics (01.07.2021)
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Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes
Kochupurakkal, Nora M, Kruger, Annie J, Tripathi, Sudipta, Zhu, Bing, Adams, La Tonya, Rainbow, Daniel B, Rossini, Aldo, Greiner, Dale L, Sayegh, Mohamed H, Wicker, Linda S, Guleria, Indira
Published in PloS one (28.02.2014)
Published in PloS one (28.02.2014)
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Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
Trzupek, Dominik, Dunstan, Melanie, Cutler, Antony J, Lee, Mercede, Godfrey, Leila, Jarvis, Lorna, Rainbow, Daniel B, Aschenbrenner, Dominik, Jones, Joanne L, Uhlig, Holm H, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Genome medicine (24.06.2020)
Published in Genome medicine (24.06.2020)
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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases
Asimit, Jennifer L., Rainbow, Daniel B., Fortune, Mary D., Grinberg, Nastasiya F., Wicker, Linda S., Wallace, Chris
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Burren, Oliver S, Rubio García, Arcadio, Javierre, Biola-Maria, Rainbow, Daniel B, Cairns, Jonathan, Cooper, Nicholas J, Lambourne, John J, Schofield, Ellen, Castro Dopico, Xaquin, Ferreira, Ricardo C, Coulson, Richard, Burden, Frances, Rowlston, Sophia P, Downes, Kate, Wingett, Steven W, Frontini, Mattia, Ouwehand, Willem H, Fraser, Peter, Spivakov, Mikhail, Todd, John A, Wicker, Linda S, Cutler, Antony J, Wallace, Chris
Published in Genome Biology (04.09.2017)
Published in Genome Biology (04.09.2017)
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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S
Published in PLoS genetics (01.06.2015)
Published in PLoS genetics (01.06.2015)
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IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Cutler, Antony J., Dopico, Xaquin Castro, Smyth, Deborah J., Mashar, Meghavi, Schuilenburg, Helen, Walker, Neil M., Dunger, David B., Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Published in Diabetologia (01.04.2015)
Published in Diabetologia (01.04.2015)
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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile
Zhang, Jia-Yuan, Whalley, Justin P, Knight, Julian C, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Genome medicine (12.09.2023)
Published in Genome medicine (12.09.2023)
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Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice
Mattner, Jochen, Mohammed, Javid P, Fusakio, Michael E, Giessler, Claudia, Hackstein, Carl-Philipp, Opoka, Robert, Wrage, Marius, Schey, Regina, Clark, Jan, Fraser, Heather I, Rainbow, Daniel B, Wicker, Linda S
Published in PLoS genetics (01.06.2019)
Published in PLoS genetics (01.06.2019)
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The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
Marcovecchio, M. Loredana, Hendriks, A. Emile J., Delfin, Carl, Battelino, Tadej, Danne, Thomas, Evans, Mark L., Johannesen, Jesper, Kaur, Simranjeet, Knip, Mikael, Overbergh, Lut, Pociot, Flemming, Todd, John A., Van der Schueren, Bart, Wicker, Linda S., Peakman, Mark, Mathieu, Chantal
Published in Diabetologia (01.06.2024)
Published in Diabetologia (01.06.2024)
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Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Published in Nature communications (28.11.2022)
Published in Nature communications (28.11.2022)
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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Bailey, Rebecca, Smyth, Deborah J, Atkinson, Mark, Plagnol, Vincent, Brusko, Todd, Lowe, Christopher E, Field, Sarah, Wicker, Linda S, Bourget, Kirsi, Walker, Neil M, Todd, John A, Clayton, David G, Cooper, Jason D
Published in Nature genetics (01.09.2007)
Published in Nature genetics (01.09.2007)
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The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus
Oliveira, João J, Karrar, Sarah, Rainbow, Daniel B, Pinder, Christopher L, Clarke, Pamela, Rubio García, Arcadio, Al-Assar, Osama, Burling, Keith, Morris, Sian, Stratton, Richard, Vyse, Tim J, Wicker, Linda S, Todd, John A, Ferreira, Ricardo C
Published in Arthritis research & therapy (27.07.2018)
Published in Arthritis research & therapy (27.07.2018)
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Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity
Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Rainbow, Daniel B., Yang, Xin, Cutler, Antony J., Oliveira, Joao, Castro Dopico, Xaquin, Smyth, Deborah J., Savinykh, Natalia, Mashar, Meghavi, Vyse, Tim J., Dunger, David B., Baxendale, Helen, Chandra, Anita, Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Published in Journal of autoimmunity (01.11.2017)
Published in Journal of autoimmunity (01.11.2017)
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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function
Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Gwynneth L, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M
Published in The Journal of immunology (1950) (01.05.2012)
Published in The Journal of immunology (1950) (01.05.2012)
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