Potentiating SLC transporter activity: Emerging drug discovery opportunities
Rives, Marie-Laure, Javitch, Jonathan A., Wickenden, Alan D.
Published in Biochemical pharmacology (01.07.2017)
Published in Biochemical pharmacology (01.07.2017)
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T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers
Fung-Leung, Wai-Ping, Edwards, Wilson, Liu, Yi, Ngo, Karen, Angsana, Julianty, Castro, Glenda, Wu, Nancy, Liu, Xuejun, Swanson, Ronald V, Wickenden, Alan D
Published in PloS one (20.01.2017)
Published in PloS one (20.01.2017)
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disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ
Gajewiak, Joanna, Azam, Layla, Imperial, Julita, Walewska, Aleksandra, Green, Brad R., Bandyopadhyay, Pradip K., Raghuraman, Shrinivasan, Ueberheide, Beatrix, Bern, Marshall, Zhou, H. Mimi, Minassian, Natali A., Hagan, Rebecca H., Flinspach, Mack, Yi Liu, Bulaj, Grzegorz, Wickenden, Alan D., Olivera, Baldomero M., Yoshikami, Doju, Zhang, Min-Min
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.02.2014)
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Sodium Channel Blockers for the Treatment of Neuropathic Pain
Bhattacharya, Anindya, Wickenden, Alan D., Chaplan, Sandra R.
Published in Neurotherapeutics (01.10.2009)
Published in Neurotherapeutics (01.10.2009)
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Activation of TRPA1 by Farnesyl Thiosalicylic Acid
Maher, Michael, Ao, Hong, Banke, Tue, Nasser, Nadia, Wu, Nyan-Tsz, Breitenbucher, J Guy, Chaplan, Sandra R, Wickenden, Alan D
Published in Molecular pharmacology (01.04.2008)
Published in Molecular pharmacology (01.04.2008)
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In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
Roeloffs, Rosemarie, Wickenden, Alan D, Crean, Christopher, Werness, Stephen, McNaughton-Smith, Grant, Stables, James, McNamara, James O, Ghodadra, Neil, Rigdon, Greg C
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
Bhattacharya, Anindya, Scott, Brian P, Nasser, Nadia, Ao, Hong, Maher, Michael P, Dubin, Adrienne E, Swanson, Devin M, Shankley, Nigel P, Wickenden, Alan D, Chaplan, Sandra R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Cardiac-Specific Elevations in Thyroid Hormone Enhance Contractility and Prevent Pressure Overload-Induced Cardiac Dysfunction
Trivieri, Maria Giovanna, Oudit, Gavin Y., Sah, Rajan, Kerfant, Benoit-Gilles, Sun, Hui, Gramolini, Anthony O., Pan, Yan, Wickenden, Alan D., Croteau, Walburga, de Escobar, Gabriella Morreale, Pekhletski, Roman, Germain, Donald St, MacLennan, David H., Backx, Peter H.
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
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Stoichiometry of Expressed KCNQ2/KCNQ3 Potassium Channels and Subunit Composition of Native Ganglionic M Channels Deduced from Block by Tetraethylammonium
Hadley, Jennifer K, Passmore, Gayle M, Tatulian, Lucine, Al-Qatari, Mona, Ye, Fei, Wickenden, Alan D, Brown, David A
Published in The Journal of neuroscience (15.06.2003)
Published in The Journal of neuroscience (15.06.2003)
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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.
Published in European journal of pharmacology (01.08.2011)
Published in European journal of pharmacology (01.08.2011)
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
Bhattacharya, Anindya, Wang, Qi, Ao, Hong, Shoblock, James R, Lord, Brian, Aluisio, Leah, Fraser, Ian, Nepomuceno, Diane, Neff, Robert A, Welty, Natalie, Lovenberg, Timothy W, Bonaventure, Pascal, Wickenden, Alan D, Letavic, Michael A
Published in British journal of pharmacology (01.10.2013)
Published in British journal of pharmacology (01.10.2013)
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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8
Maher, Michael P, Wu, Nyantsz, Ravula, Suchitra, Ameriks, Michael K, Savall, Brad M, Liu, Changlu, Lord, Brian, Wyatt, Ryan M, Matta, Jose A, Dugovic, Christine, Yun, Sujin, Ver Donck, Luc, Steckler, Thomas, Wickenden, Alan D, Carruthers, Nicholas I, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
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A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)
Damm-Ganamet, Kelly L., Rives, Marie-Laure, Wickenden, Alan D., McAllister, Heather M., Mirzadegan, Taraneh
Published in The Journal of biological chemistry (27.03.2020)
Published in The Journal of biological chemistry (27.03.2020)
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The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site
Padilla, Karen, Wickenden, Alan D., Gerlach, Aaron C., McCormack, Ken
Published in Neuroscience letters (13.11.2009)
Published in Neuroscience letters (13.11.2009)
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Recent advances in the biology and medicinal chemistry of TRPA1
Rech, Jason C, Eckert, William A, Maher, Michael P, Banke, Tue, Bhattacharya, Anindya, Wickenden, Alan D
Published in Future medicinal chemistry (01.05.2010)
Published in Future medicinal chemistry (01.05.2010)
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Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties
Knowland, Daniel, Gu, Shenyan, Eckert, 3rd, William A, Dawe, G Brent, Matta, Jose A, Limberis, James, Wickenden, Alan D, Bhattacharya, Anindya, Bredt, David S
Published in The Journal of clinical investigation (02.11.2020)
Published in The Journal of clinical investigation (02.11.2020)
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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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