Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published in Nature communications (02.07.2015)
Published in Nature communications (02.07.2015)
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Journal Article
Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Journal Article
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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HSP90-표적화 접합체 및 이의 제형
BILODEAU MARK T, KADIYALA SUDHAKAR, WOOSTER RICHARD, WHITE BRIAN H, MOREAU BENOIT
Year of Publication 15.12.2020
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Year of Publication 15.12.2020
Patent
표적화된 접합체 및 이의 입자 및 제형
BILODEAU MARK T, LIM SOO PATRICK, SWERYDA KRAWIEC BEATA, ALARGOVA ROSSITZA G, BAZINET PATRICK ROSAIRE, DUNBAR CRAIG A, WHITE BRIAN H, SHINDE RAJESH R, MOREAU BENOIT
Year of Publication 05.03.2018
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Year of Publication 05.03.2018
Patent
SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
CASAUBON REBECCA, KOPPETSCH KARSTEN, SZCZEPANKIEWICZ BRUCE G, CALDWELL RICHARD DANA, OALMANN CHRISTOPHER, BLUM CHARLES A, DISCH JEREMY S, NG PUI YEE, MILLER WILLIAM HENRY, FOX RYAN MICHAEL, PERNI ROBERT B, WHITE BRIAN H
Year of Publication 19.07.2017
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Year of Publication 19.07.2017
Patent
SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
CASAUBON REBECCA, KOPPETSCH KARSTEN, SZCZEPANKIEWICZ BRUCE G, CALDWELL RICHARD DANA, OALMANN CHRISTOPHER, BLUM CHARLES A, DISCH JEREMY S, NG PUI YEE, PERNI ROBERT B, FOX RYAN MICHAEL, WHITE BRIAN H
Year of Publication 18.01.2016
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Year of Publication 18.01.2016
Patent
Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 3094: Discovery of a HeliconTM peptide inhibitor of the beta-catenin-TCF interaction with in vivo activity
White, Brian H., Si, Yaguang, Cappucci, Sarah, Li, Zhi, Ramirez, Jessica D., Ponthier, Charles M., Visness, Erica, Du, Peicheng, Choi, Minjung, Beerepoot, Pieter C., Ortet, Paula C., Jewett, Ivan T., Alfaro-Lopez, Josue, Agarwal, Sorabh, La, Daniel, Fulgham, Aaron, McGee, John H., Orford, Keith, Hurov, Jonathan B., Tremblay, Martin R., Verdine, Gregory L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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