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Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase
Shi, Dong-Fang, Wheelhouse, Richard T, Sun, Daekyu, Hurley, Laurence H
Published in Journal of medicinal chemistry (20.12.2001)
Published in Journal of medicinal chemistry (20.12.2001)
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Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase
Stell, J. Godfrey P., Wheelhouse, Richard T., Wright, Colin W.
Published in Journal of pharmacy and pharmacology (01.02.2012)
Published in Journal of pharmacy and pharmacology (01.02.2012)
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Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex
Wheelhouse, Richard T, Garbett, Nichola C, Buurma, Niklaas J, Chaires, Jonathan B
Published in Angewandte Chemie (International ed.) (19.04.2010)
Published in Angewandte Chemie (International ed.) (19.04.2010)
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Specific transport of temozolomide does not override DNA repair-mediated chemoresistance
Bahrami, Katayun, Kärkkäinen, Jussi, Bibi, Sania, Huttunen, Johanna, Tampio, Janne, Montaser, Ahmed B., Moody, Catherine L., Lehtonen, Marko, Rautio, Jarkko, Wheelhouse, Richard T., Huttunen, Kristiina M.
Published in European journal of pharmaceutical sciences (01.04.2024)
Published in European journal of pharmaceutical sciences (01.04.2024)
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Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands
Allison, Simon J., Sadiq, Maria, Baronou, Efstathia, Cooper, Patricia A., Dunnill, Chris, Georgopoulos, Nikolaos T., Latif, Ayşe, Shepherd, Samantha, Shnyder, Steve D., Stratford, Ian J., Wheelhouse, Richard T., Willans, Charlotte E., Phillips, Roger M.
Published in Cancer letters (10.09.2017)
Published in Cancer letters (10.09.2017)
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Inhibition of cobalamin‐dependent methionine synthase by substituted benzo‐fused heterocycles
Banks, Elizabeth C., Doughty, Stephen W., Toms, Steven M., Wheelhouse, Richard T., Nicolaou, Anna
Published in The FEBS journal (01.01.2007)
Published in The FEBS journal (01.01.2007)
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Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells
Allison, Simon J., Cooke, David, Davidson, Francesca S., Elliott, Paul I. P., Faulkner, Robert A., Griffiths, Hollie B. S., Harper, Owen J., Hussain, Omar, Owen‐Lynch, P. Jane, Phillips, Roger M., Rice, Craig R., Shepherd, Samantha L., Wheelhouse, Richard T.
Published in Angewandte Chemie International Edition (26.07.2018)
Published in Angewandte Chemie International Edition (26.07.2018)
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Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth
Ramirez, Yulian P., Mladek, Ann C., Phillips, Roger M., Gynther, Mikko, Rautio, Jarkko, Ross, Alonzo H., Wheelhouse, Richard T., Sakaria, Jann N.
Published in Molecular cancer therapeutics (01.01.2015)
Published in Molecular cancer therapeutics (01.01.2015)
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Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107]
Allison, Simon J., Sadiq, Maria, Baronou, Efstathia, Cooper, Patricia A., Dunnill, Chris, Georgopoulos, Nikolaos T., Latif, Ayse, Shepherd, Samantha, Shnyder, Steve D., Stratford, Ian J., Wheelhouse, Richard T., Willans, Charlotte E., Phillips, Roger M.
Published in Cancer letters (01.09.2018)
Published in Cancer letters (01.09.2018)
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Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6‑Methylguanine-DNA-methyltransferase, DNA Mismatch Repair, and p53
Pletsas, Dimitrios, Garelnabi, Elrashied A. E, Li, Li, Phillips, Roger M, Wheelhouse, Richard T
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Stabilization of a Bimolecular Triplex by 3′-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation
Evans, Kathryn, Bhamra, Inder, Wheelhouse, Richard T., Arnold, John R. P., Cosstick, Richard, Fisher, Julie
Published in Chemistry : a European journal (04.05.2015)
Published in Chemistry : a European journal (04.05.2015)
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Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA
Wheelhouse, Richard T, Sun, Daekyu, Han, Haiyong, Han, Frank Xiaoguang, Hurley, Laurence H
Published in Journal of the American Chemical Society (08.04.1998)
Published in Journal of the American Chemical Society (08.04.1998)
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Synthesis and growth-inhibitory activities of imidazo[5,1- d ]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position
Cousin, David, Hummersone, Marc G., Bradshaw, Tracey D., Zhang, Jihong, Moody, Christopher J., Foreiter, Magdalena B., Summers, Helen S., Lewis, William, Wheelhouse, Richard T., Stevens, Malcolm F. G.
Published in MedChemComm (01.03.2018)
Published in MedChemComm (01.03.2018)
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Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
IZBICKA, E, WHEELHOUSE, R. T, RAYMOND, E, DAVIDSON, K. K, LAWRENCE, R. A, SUN, D, WINDLE, B. E, HURLEY, L. H, VON HOFF, D. D
Published in Cancer research (Chicago, Ill.) (01.02.1999)
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Published in Cancer research (Chicago, Ill.) (01.02.1999)
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Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells
Allison, Simon J., Cooke, David, Davidson, Francesca S., Elliott, Paul I. P., Faulkner, Robert A., Griffiths, Hollie B. S., Harper, Owen J., Hussain, Omar, Owen‐Lynch, P. Jane, Phillips, Roger M., Rice, Craig R., Shepherd, Samantha L., Wheelhouse, Richard T.
Published in Angewandte Chemie (26.07.2018)
Published in Angewandte Chemie (26.07.2018)
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Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR
Garelnabi, Elrashied A. E, Pletsas, Dimitrios, Li, Li, Kiakos, Konstantinos, Karodia, Nazira, Hartley, John A, Phillips, Roger M, Wheelhouse, Richard T
Published in ACS medicinal chemistry letters (13.12.2012)
Published in ACS medicinal chemistry letters (13.12.2012)
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Minor structural modifications to alchemix influence mechanism of action and pharmacological activity
Abdallah, Qasem M.A., Phillips, Roger M., Johansson, Fredrik, Helleday, Thomas, Cosentino, Laura, Abdel-Rahman, Hamdy, Etzad, Jasarat, Wheelhouse, Richard T., Kiakos, Konstantinos, Bingham, John P., Hartley, John A., Patterson, Laurence H., Pors, Klaus
Published in Biochemical pharmacology (01.06.2012)
Published in Biochemical pharmacology (01.06.2012)
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