Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits
Wong, Pancras C., Crain, Earl J., Bozarth, Jeffrey M., Wu, Yiming, Dilger, Andrew K., Wexler, Ruth R., Ewing, William R., Gordon, David, Luettgen, Joseph M.
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Published in Journal of thrombosis and haemostasis (01.02.2022)
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Factor Xa Inhibitors: Next-Generation Antithrombotic Agents
Pinto, Donald J. P, Smallheer, Joanne M, Cheney, Daniel L, Knabb, Robert M, Wexler, Ruth R
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Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies
Wexler, Judith R, Plachetzki, David C, Kopp, Artyom
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Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Pinto, Donald J. P, Orwat, Michael J, Koch, Stephanie, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela, Wong, Pancras C, Rendina, Alan R, Luettgen, Joseph M, Knabb, Robert M, He, Kan, Xin, Baomin, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (01.11.2007)
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Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)
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Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies
WONG, P. C., CRAIN, E. J., XIN, B., WEXLER, R. R., LAM, P. Y. S., PINTO, D. J., LUETTGEN, J. M., KNABB, R. M.
Published in Journal of thrombosis and haemostasis (01.05.2008)
Published in Journal of thrombosis and haemostasis (01.05.2008)
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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R
Published in Journal of medicinal chemistry (24.03.2005)
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Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
Qiao, Jennifer X, Wang, Tammy C, Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A, Spronk, Steven A, Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M, Abell, Lynn M, Hua, Ji, Price, Laura A, Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E, Bostwick, Jeffrey S, Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa
Wong, Pancras C., Quan, Mimi L., Watson, Carol A., Crain, Earl J., Harpel, Mark R., Rendina, Alan R., Luettgen, Joseph M., Wexler, Ruth R., Schumacher, William A., Seiffert, Dietmar A.
Published in Journal of thrombosis and thrombolysis (01.11.2015)
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Outcomes of Preoperative Versus Postoperative Radiation for Heterotopic Ossification Prevention in Pediatric Patients With Cerebral Palsy Undergoing Proximal Femoral Resection
Hess, C.B, Stein-Wexler, R, Qi, L, Davids, J.R, Fragoso, R.C
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Involvement of endothelial PECAM-1/CD31 in angiogenesis
DeLisser, HM, Christofidou-Solomidou, M, Strieter, RM, Burdick, MD, Robinson, CS, Wexler, RS, Kerr, JS, Garlanda, C, Merwin, JR, Madri, JA, Albelda, SM
Published in The American journal of pathology (01.09.1997)
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Published in The American journal of pathology (01.09.1997)
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Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N‑[(1R)‑1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)
Qiao, Jennifer X, Wang, Tammy C, Adam, Leonard P, Chen, Alice Ye A, Taylor, David S, Yang, Richard Z, Zhuang, Shaobin, Sleph, Paul G, Li, Julia P, Li, Danshi, Yin, Xiaohong, Chang, Ming, Chen, Xue-Qing, Shen, Hong, Li, Jianqing, Smith, Daniel, Wu, Dauh-Rurng, Leith, Leslie, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Miller, Michael M, Bilder, Donna, Rampulla, Richard, Li, Yi-Xin, Xu, Carrie, Lawrence, R. Michael, Poss, Michael A, Levesque, Paul, Gordon, David A, Huang, Christine S, Finlay, Heather J, Wexler, Ruth R, Salvati, Mark E
Published in Journal of medicinal chemistry (25.11.2015)
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Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor
He, Kan, Luettgen, Joseph M., Zhang, Donglu, He, Bing, Grace, James E., Xin, Baomin, Pinto, Donald J. P., Wong, Pancras C., Knabb, Robert M., Lam, Patrick Y. S., Wexler, Ruth R., Grossman, Scott J.
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Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy
Wexler, Ruth R, Greenlee, William J, Irvin, John D, Goldberg, Michael R, Prendergast, Kristine, Smith, Ronald D, Timmermans, Pieter B. M. W. M
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
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Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa
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Published in Bioorganic & medicinal chemistry letters (15.07.2008)
Published in Bioorganic & medicinal chemistry letters (15.07.2008)
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