SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies
DECKERT, Jutta, WETZEL, Marie-Cécile, DUMONTET, Charles, PLESA, Adriana, CHIRON, Marielle, LEJEUNE, Pascale, CHITTENDEN, Thomas, PARK, Peter U, BLANC, Véronique, BARTLE, Laura M, SKALETSKAYA, Anna, GOLDMACHER, Victor S, VALLEE, François, QING, Zhou-Liu, FERRARI, Paul, POUZIEUX, Stéphanie, LAHOUTE, Charlotte
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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SAR650984: A Potent Anti-CD38 Therapeutic Antibody with Three Mechanisms of Action (Apoptosis, ADCC, CDC) for Hematological Malignancies
Park, Peter U., Blanc, Véronique, Deckert, Jutta, Lejeune, Pascale, Bartle, Laura M., Skaletskaya, Anna, Mayo, Michele F., Zhang, Chonghui, Wetzel, Marie-Cécile, Tavares, Daniel J., Lutz, Robert J., Chittenden, Thomas, Bissery, Marie-Christine, Lambert, John M., Goldmacher, Victor S.
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Coniosetin, a Novel Tetramic Acid Antibiotic from Coniochaeta ellipsoidea DSM 13856
SEGETH, MARIAN PAUL, BONNEFOY, ALAIN, BRÖNSTRUP, MARK, KNAUF, MARTIN, SCHUMMER, DIETMAR, TOTI, LUIGI, VÉRTESY, LÁSZLÓ, WETZEL-RAYNAL, MARIE-CÉCILE, WINK, JOACHIM, SEIBERT, GERHARD
Published in Journal of antibiotics (01.02.2003)
Published in Journal of antibiotics (01.02.2003)
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17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development
Marchais-Oberwinkler, Sandrine, Henn, Claudia, Möller, Gabriele, Klein, Tobias, Negri, Matthias, Oster, Alexander, Spadaro, Alessandro, Werth, Ruth, Wetzel, Marie, Xu, Kuiying, Frotscher, Martin, Hartmann, Rolf W., Adamski, Jerzy
Published in The Journal of steroid biochemistry and molecular biology (01.05.2011)
Published in The Journal of steroid biochemistry and molecular biology (01.05.2011)
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Epiphyseal lymphoid infiltrates of the knee in adolescents
Urbanschitz, Lukas, Agten, Christoph Amadeus, Bühler, Marco Matteo, Wetzel, Marie Sarah, Müller, Daniel Andreas
Published in Skeletal radiology (01.04.2021)
Published in Skeletal radiology (01.04.2021)
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New Drug-Like Hydroxyphenylnaphthol Steroidomimetics As Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Estrogen-Dependent Diseases
Marchais-Oberwinkler, Sandrine, Wetzel, Marie, Ziegler, Erika, Kruchten, Patricia, Werth, Ruth, Henn, Claudia, Hartmann, Rolf W, Frotscher, Martin
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Introduction of an Electron Withdrawing Group on the Hydroxyphenylnaphthol Scaffold Improves the Potency of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors
Wetzel, Marie, Marchais-Oberwinkler, Sandrine, Perspicace, Enrico, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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3 -123 3 / 123 ANTI-CD3 ANTIBODIES ANTI-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO CD3 AND/OR CD123
CARREZ CHANTAL, LEMOINE CENDRINE, GUERIF STEPHANE, LEUSCHNER WULF DIRK, BENINGA JOCHEN, KROLL KATJA, SCHNEIDER MARION, RAO ERCOLE, BARRIERE CEDRIC, ALBRECHT JANA, BEIL CHRISTIAN, LANGE CHRISTIAN, WETZEL MARIE CECILE, WONEROW PETER
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent
Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis
Wetzel, Marie, Gargano, Emanuele M., Hinsberger, Stefan, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Published in European journal of medicinal chemistry (2012)
Published in European journal of medicinal chemistry (2012)
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Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis
Marchais-Oberwinkler, Sandrine, Xu, Kuiying, Wetzel, Marie, Perspicace, Enrico, Negri, Matthias, Meyer, Arne, Odermatt, Alex, Möller, Gabriele, Adamski, Jerzy, Hartmann, Rolf W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors
Xu, Kuiying, Al-Soud, Yaseen A., Wetzel, Marie, Hartmann, Rolf W., Marchais-Oberwinkler, Sandrine
Published in European journal of medicinal chemistry (01.12.2011)
Published in European journal of medicinal chemistry (01.12.2011)
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Journal Article
Structural characterization of a potent humanized anti-CD38 antibody in phase I
Vallée, Francois, Pouzieux, Stephanie, Rak, Alexey, Michoux, François, Wetzel, Marie-Cécile, Deckert, Jutta, Kannt, Aimo, Blanc, Veronique, Mikol, Vincent
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
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Abstract 4735: SAR650984: Characterization of a potent phase I humanized anti-CD38 antibody for the treatment of multiple myeloma and other hematologic malignancies
Wetzel, Marie-Cécile, Nicolazzi, Céline, Vallée, François, Deckert, Jutta, Dumontet, Charles, Plesa, Adriana, Kannt, Aimo, Mikol, Vincent, Chiron, Marielle, Vincent, Loïc, Blanc, Veronique
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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