Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
Osterberg, Valerie R., Spinelli, Kateri J., Weston, Leah J., Luk, Kelvin C., Woltjer, Randall L., Unni, Vivek K.
Published in Cell reports (Cambridge) (03.03.2015)
Published in Cell reports (Cambridge) (03.03.2015)
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Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism
Weston, Leah J, Bowman, Anna M, Osterberg, Valerie R, Meshul, Charles K, Woltjer, Randall L, Unni, Vivek K
Published in International journal of molecular sciences (04.12.2022)
Published in International journal of molecular sciences (04.12.2022)
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In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129
Weston, Leah J., Cook, Zoe T., Stackhouse, Teresa L., Sal, Mehtab K., Schultz, Baergen I., Tobias, Zachary J.C., Osterberg, Valerie R., Brockway, Nicole L., Pizano, Saheli, Glover, Greta, Weissman, Tamily A., Unni, Vivek K.
Published in Neurobiology of disease (01.05.2021)
Published in Neurobiology of disease (01.05.2021)
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Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy
Schaser, Allison J, Stackhouse, Teresa L, Weston, Leah J, Kerstein, Patrick C, Osterberg, Valerie R, López, Claudia S, Dickson, Dennis W, Luk, Kelvin C, Meshul, Charles K, Woltjer, Randall L, Unni, Vivek K
Published in Acta neuropathologica communications (28.08.2020)
Published in Acta neuropathologica communications (28.08.2020)
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Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
Schaser, Allison J., Osterberg, Valerie R., Dent, Sydney E., Stackhouse, Teresa L., Wakeham, Colin M., Boutros, Sydney W., Weston, Leah J., Owen, Nichole, Weissman, Tamily A., Luna, Esteban, Raber, Jacob, Luk, Kelvin C., McCullough, Amanda K., Woltjer, Randall L., Unni, Vivek K.
Published in Scientific reports (29.07.2019)
Published in Scientific reports (29.07.2019)
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Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies
Weston, Leah J., Stackhouse, Teresa L., Spinelli, Kateri J., Boutros, Sydney W., Rose, Elizabeth P., Osterberg, Valerie R., Luk, Kelvin C., Raber, Jacob, Weissman, Tamily A., Unni, Vivek K.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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