Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization
Damon, David B, Dugger, Robert W, Magnus-Aryitey, George, Ruggeri, Roger B, Wester, Ronald T, Tu, Meihua, Abramov, Yuriy
Published in Organic process research & development (01.05.2006)
Published in Organic process research & development (01.05.2006)
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Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Raising High-Density Lipoprotein in Humans Through Inhibition of Cholesteryl Ester Transfer Protein: An Initial Multidose Study of Torcetrapib
Clark, Ronald W, Sutfin, Tamara A, Ruggeri, Roger B, Willauer, Ann T, Sugarman, Eliot D, Magnus-Aryitey, George, Cosgrove, Patricia G, Sand, Thomas M, Wester, Ronald T, Williams, John A, Perlman, Michael E, Bamberger, Mark J
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2004)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2004)
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Journal Article
Zoniporide: a potent and highly selective inhibitor of human Na +/H + exchanger-1
Marala, Ravi B, Brown, Janice A, Kong, Jimmy X, Tracey, W.Ross, Knight, Delvin R, Wester, Ronald T, Sun, Dexue, Kennedy, Scott P, Hamanaka, Ernest S, Ruggeri, Roger B, Hill, Roger J
Published in European journal of pharmacology (06.09.2002)
Published in European journal of pharmacology (06.09.2002)
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Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility
Guzman-Perez, Angel, Wester, Ronald T., Allen, Mary C., Brown, Janice A., Buchholz, Allan R., Cook, Ewell R., Day, Wesley W., Hamanaka, Ernest S., Kennedy, Scott P., Knight, Delvin R., Kowalczyk, Paul J., Marala, Ravi B., Mularski, Christian J., Novomisle, William A., Ruggeri, Roger B., Tracey, W.Ross, Hill, Roger J.
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
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Journal Article
Cloning, Expression and Pharmacological Characterization of Rabbit Adenosine A1 and A3 Receptors
Hill, R J, Oleynek, J J, Hoth, C F, Kiron, M A, Weng, W, Wester, R T, Tracey, W R, Knight, D R, Buchholz, R A, Kennedy, S P
Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
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Applications of the 3-methyl-.gamma.-butyrolactone strategy to the synthesis of polypropionates: the Prelog-Djerassi lactonic ester, ent-invictolide, and the C19-C27 fragment of rifamycin S
Ziegler, Frederick E, Cain, William T, Kneisley, Alyssa, Stirchak, Eugene P, Wester, Ronald T
Published in Journal of the American Chemical Society (01.08.1988)
Published in Journal of the American Chemical Society (01.08.1988)
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Journal Article
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase
Duplantier, Allen J, Andresen, Catharine J, Cheng, John B, Cohan, Victoria L, Decker, Christian, DiCapua, Frank M, Kraus, Kenneth G, Johnson, Kerry L, Turner, Claudia R, UmLand, John P, Watson, John W, Wester, Ronald T, Williams, Alison S, Williams, John A
Published in Journal of medicinal chemistry (18.06.1998)
Published in Journal of medicinal chemistry (18.06.1998)
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A Novel Sodium-Hydrogen Exchanger Isoform-1 Inhibitor, Zoniporide, Reduces Ischemic Myocardial Injury in Vitro and in Vivo
Knight, D R, Smith, A H, Flynn, D M, MacAndrew, J T, Ellery, S S, Kong, J X, Marala, R B, Wester, R T, Guzman-Perez, A, Hill, R J, Magee, W P, Tracey, W R
Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.2001)
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TYK2 INHIBITORS AND USES THEREOF
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Year of Publication 17.04.2024
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Year of Publication 17.04.2024
Patent
TYK2 INHIBITORS AND USES THEREOF
HARRIMAN, Geraldine C, MASSE, Craig E, ROMERO, Donna L, DAHLGREN, Markus, GREENWOOD, Jeremy Robert, WESTER, Ronald T, SHELLEY, Mee, MONDAL, Sayan, KENNEDY-SMITH, Joshua Jahmil
Year of Publication 28.02.2024
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Year of Publication 28.02.2024
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TYK2 INHIBITORS AND USES THEREOF
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Year of Publication 07.12.2023
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Year of Publication 07.12.2023
Patent
TYK2 INHIBITORS AND USES THEREOF
HARRIMAN, Geraldine C, MASSE, Craig E, ROMERO, Donna L, DAHLGREN, Markus, GREENWOOD, Jeremy Robert, WESTER, Ronald T, SHELLEY, Mee, MONDAL, Sayan, KENNEDY-SMITH, Joshua Jahmil
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
Patent
TYK2 INHIBITORS AND USES THEREOF
HARRIMAN, Geraldine C, MASSE, Craig E, ROMERO, Donna L, DAHLGREN, Markus, GREENWOOD, Jeremy Robert, WESTER, Ronald T, SHELLEY, Mee, MONDAL, Sayan, KENNEDY-SMITH, Joshua Jahmil
Year of Publication 25.10.2023
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Year of Publication 25.10.2023
Patent
TYK2 INHIBITORS AND USES THEREOF
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Year of Publication 09.03.2023
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Year of Publication 09.03.2023
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TYK2 inhibitors and uses thereof
Greenwood, Jeremy Robert, Kennedy-Smith, Joshua Jahmil, Masse, Craig E, Shelley, Mee, Romero, Donna L, Dahlgren, Markus, Robinson, Shaughnessy, Harriman, Geraldine C, Wester, Ronald T, Mondal, Sayan
Year of Publication 06.09.2022
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Year of Publication 06.09.2022
Patent