G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
Prentzell, Mirja Tamara, Rehbein, Ulrike, Cadena Sandoval, Marti, De Meulemeester, Ann-Sofie, Baumeister, Ralf, Brohée, Laura, Berdel, Bianca, Bockwoldt, Mathias, Carroll, Bernadette, Chowdhury, Suvagata Roy, von Deimling, Andreas, Demetriades, Constantinos, Figlia, Gianluca, de Araujo, Mariana Eca Guimaraes, Heberle, Alexander M., Heiland, Ines, Holzwarth, Birgit, Huber, Lukas A., Jaworski, Jacek, Kedra, Magdalena, Kern, Katharina, Kopach, Andrii, Korolchuk, Viktor I., van 't Land-Kuper, Ineke, Macias, Matylda, Nellist, Mark, Palm, Wilhelm, Pusch, Stefan, Ramos Pittol, Jose Miguel, Reil, Michèle, Reintjes, Anja, Reuter, Friederike, Sampson, Julian R., Scheldeman, Chloë, Siekierska, Aleksandra, Stefan, Eduard, Teleman, Aurelio A., Thomas, Laura E., Torres-Quesada, Omar, Trump, Saskia, West, Hannah D., de Witte, Peter, Woltering, Sandra, Yordanov, Teodor E., Zmorzynska, Justyna, Opitz, Christiane A., Thedieck, Kathrin
Published in Cell (04.02.2021)
Published in Cell (04.02.2021)
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Germline MBD4 deficiency causes a multi-tumor predisposition syndrome
Palles, Claire, West, Hannah D., Chew, Edward, Galavotti, Sara, Flensburg, Christoffer, Grolleman, Judith E., Jansen, Erik A.M., Curley, Helen, Chegwidden, Laura, Arbe-Barnes, Edward H., Lander, Nicola, Truscott, Rebekah, Pagan, Judith, Bajel, Ashish, Sherwood, Kitty, Martin, Lynn, Thomas, Huw, Georgiou, Demetra, Fostira, Florentia, Goldberg, Yael, Adams, David J., van der Biezen, Simone A.M., Christie, Michael, Clendenning, Mark, Thomas, Laura E., Deltas, Constantinos, Dimovski, Aleksandar J., Dymerska, Dagmara, Lubinski, Jan, Mahmood, Khalid, van der Post, Rachel S., Sanders, Mathijs, Weitz, Jürgen, Taylor, Jenny C., Turnbull, Clare, Vreede, Lilian, van Wezel, Tom, Whalley, Celina, Arnedo-Pac, Claudia, Caravagna, Giulio, Cross, William, Chubb, Daniel, Frangou, Anna, Gruber, Andreas J., Kinnersley, Ben, Noyvert, Boris, Church, David, Graham, Trevor, Houlston, Richard, Lopez-Bigas, Nuria, Sottoriva, Andrea, Wedge, David, Jenkins, Mark A., Kuiper, Roland P., Roberts, Andrew W., Cheadle, Jeremy P., Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, Koelzer, Viktor H., Rivas, Andres Dacal, Winship, Ingrid M., Ponte, Clara Ruiz, Buchanan, Daniel D., Power, Derek G., Green, Andrew, Tomlinson, Ian P.M., Sampson, Julian R., Majewski, Ian J., de Voer, Richarda M.
Published in American journal of human genetics (05.05.2022)
Published in American journal of human genetics (05.05.2022)
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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Robinson, Philip S, Thomas, Laura E, Abascal, Federico, Jung, Hyunchul, Harvey, Luke M R, West, Hannah D, Olafsson, Sigurgeir, Lee, Bernard C H, Coorens, Tim H H, Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A, Lensing, Stefanie V, Buczacki, Simon J A, Ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J, Martincorena, Iñigo, Sampson, Julian R, Stratton, Michael R
Published in Nature communications (08.07.2022)
Published in Nature communications (08.07.2022)
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PIGA mutations and glycosylphosphatidylinositol anchor dysregulation in polyposis-associated duodenal tumorigenesis
Meuser, Elena, Chang, Kyle, Walters, Angharad, Hurley, Joanna J, West, Hannah D, Perry, Iain, Mort, Matthew, Reyes-Uribe, Laura, Truscott, Rebekah, Jones, Nicholas, Lawrence, Rachel, Jenkins, Gareth, Giles, Peter, Dolwani, Sunil, Al-Sarireh, Bilal, Hawkes, Neil, Short, Emma, Williams, Geraint T, Taggart, Melissa W, Luetchford, Kim, Lynch, Patrick M, Terlouw, Diantha, Nielsen, Maartje, Walton, Sarah-Jane, Latchford, Andrew, Clark, Susan K, Sampson, Julian R, Vilar, Eduardo, Thomas, Laura E
Published in Molecular cancer research (04.06.2024)
Published in Molecular cancer research (04.06.2024)
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Targeted Genomic Sequencing of TSC1 and TSC2 Reveals Causal Variants in Individuals for Whom Previous Genetic Testing for Tuberous Sclerosis Complex Was Normal
West, Hannah D., Nellist, Mark, Brouwer, Rutger W. W., van den Hout-van Vroonhoven, Mirjam C. G. N., de Almeida, Luiz Gustavo Dufner, Hendriks, Femke, Elfferich, Peter, Raja, Meera, Giles, Peter, Alfano, Rosa M., Peron, Angela, Sznajer, Yves, De Waele, Liesbeth, Jansen, Anna, Koopmans, Marije, Kievit, Anneke, Farach, Laura S., Northrup, Hope, Sampson, Julian R., Thomas, Laura E., van IJcken, Wilfred F. J.
Published in Human mutation (13.07.2023)
Published in Human mutation (13.07.2023)
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A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients
Wills, Christopher, He, Yazhou, Summers, Matthew G., Lin, Yi, Phipps, Amanda I., Watts, Katie, Law, Philip J., Al-Tassan, Nada A., Maughan, Timothy S., Kaplan, Richard, Houlston, Richard S., Peters, Ulrike, Newcomb, Polly A., Chan, Andrew T., Buchanan, Daniel D., Gallinger, Steve, Marchand, Loic L., Pai, Rish K., Shi, Qian, Alberts, Steven R., Gray, Victoria, West, Hannah D., Escott-Price, Valentina, Dunlop, Malcolm G., Cheadle, Jeremy P.
Published in European journal of cancer (1990) (01.12.2021)
Published in European journal of cancer (1990) (01.12.2021)
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Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease
Wills, Christopher, Houseman, Amy, Watts, Katie, Maughan, Timothy S, Fisher, David, Houlston, Richard S, West, Hannah D, Escott-Price, Valentina, Cheadle, Jeremy P
Published in BJC Reports (01.01.2023)
Published in BJC Reports (01.01.2023)
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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
Robinson, Philip S, Thomas, Laura E, Abascal, Federico, Jung, Hyunchul, Harvey, Luke, West, Hannah D, Olafsson, Sigurgeir, Lee, Bernard Ch, Coorens, Tim, Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Sanders, Mathijs A, Lensing, Stefanie, Buczacki, Simon Ja, Rogier Ten Hoopen, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J, Martincorena, Inigo, Sampson, Julian R, Stratton, Michael R
Published in bioRxiv (22.10.2021)
Published in bioRxiv (22.10.2021)
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