Ubiquitination in the regulation of inflammatory cell death and cancer
Cockram, Peter E, Kist, Matthias, Prakash, Sumit, Chen, Si-Han, Wertz, Ingrid E, Vucic, Domagoj
Published in Cell death and differentiation (01.02.2021)
Published in Cell death and differentiation (01.02.2021)
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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
Vucic, Domagoj, Wertz, Ingrid E, Dixit, Vishva M
Published in Nature reviews. Molecular cell biology (23.06.2011)
Published in Nature reviews. Molecular cell biology (23.06.2011)
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Signaling to NF-kappaB: regulation by ubiquitination
Wertz, Ingrid E, Dixit, Vishva M
Published in Cold Spring Harbor perspectives in biology (01.03.2010)
Published in Cold Spring Harbor perspectives in biology (01.03.2010)
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Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Zhou, Qing, Wang, Hongying, Schwartz, Daniella M, Stoffels, Monique, Park, Yong Hwan, Zhang, Yuan, Yang, Dan, Demirkaya, Erkan, Takeuchi, Masaki, Tsai, Wanxia Li, Lyons, Jonathan J, Yu, Xiaomin, Ouyang, Claudia, Chen, Celeste, Chin, David T, Zaal, Kristien, Chandrasekharappa, Settara C, P Hanson, Eric, Yu, Zhen, Mullikin, James C, Hasni, Sarfaraz A, Wertz, Ingrid E, Ombrello, Amanda K, Stone, Deborah L, Hoffmann, Patrycja, Jones, Anne, Barham, Beverly K, Leavis, Helen L, van Royen-Kerkof, Annet, Sibley, Cailin, Batu, Ezgi D, Gül, Ahmet, Siegel, Richard M, Boehm, Manfred, Milner, Joshua D, Ozen, Seza, Gadina, Massimo, Chae, JaeJin, Laxer, Ronald M, Kastner, Daniel L, Aksentijevich, Ivona
Published in Nature genetics (01.01.2016)
Published in Nature genetics (01.01.2016)
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Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation
Rougé, Lionel, Bainbridge, Travis W., Kwok, Michael, Tong, Raymond, Di Lello, Paola, Wertz, Ingrid E., Maurer, Till, Ernst, James A., Murray, Jeremy
Published in Structure (London) (02.08.2016)
Published in Structure (London) (02.08.2016)
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Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
Wertz, Ingrid E, Newton, Kim, Seshasayee, Dhaya, Kusam, Saritha, Lam, Cynthia, Zhang, Juan, Popovych, Nataliya, Helgason, Elizabeth, Schoeffler, Allyn, Jeet, Surinder, Ramamoorthi, Nandhini, Kategaya, Lorna, Newman, Robert J, Horikawa, Keisuke, Dugger, Debra, Sandoval, Wendy, Mukund, Susmith, Zindal, Anuradha, Martin, Flavius, Quan, Clifford, Tom, Jeffrey, Fairbrother, Wayne J, Townsend, Michael, Warming, Søren, DeVoss, Jason, Liu, Jinfeng, Dueber, Erin, Caplazi, Patrick, Lee, Wyne P, Goodnow, Christopher C, Balazs, Mercedesz, Yu, Kebing, Kolumam, Ganesh, Dixit, Vishva M
Published in Nature (London) (17.12.2015)
Published in Nature (London) (17.12.2015)
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Molecular glue CELMoD compounds are regulators of cereblon conformation
Watson, Edmond R., Novick, Scott, Matyskiela, Mary E., Chamberlain, Philip P., H. de la Peña, Andres, Zhu, Jinyi, Tran, Eileen, Griffin, Patrick R., Wertz, Ingrid E., Lander, Gabriel C.
Published in Science (American Association for the Advancement of Science) (04.11.2022)
Published in Science (American Association for the Advancement of Science) (04.11.2022)
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Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
Guan, Jane, Zhou, Wei, Hafner, Marc, Blake, Robert A., Chalouni, Cecile, Chen, Irene P., De Bruyn, Tom, Giltnane, Jennifer M., Hartman, Steven J., Heidersbach, Amy, Houtman, Rene, Ingalla, Ellen, Kategaya, Lorn, Kleinheinz, Tracy, Li, Jun, Martin, Scott E., Modrusan, Zora, Nannini, Michelle, Oeh, Jason, Ubhayakar, Savita, Wang, Xiaojing, Wertz, Ingrid E., Young, Amy, Yu, Mamie, Sampath, Deepak, Hager, Jeffrey H., Friedman, Lori S., Daemen, Anneleen, Metcalfe, Ciara
Published in Cell (08.08.2019)
Published in Cell (08.08.2019)
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USP7 small-molecule inhibitors interfere with ubiquitin binding
Kategaya, Lorna, Di Lello, Paola, Rougé, Lionel, Pastor, Richard, Clark, Kevin R, Drummond, Jason, Kleinheinz, Tracy, Lin, Eva, Upton, John-Paul, Prakash, Sumit, Heideker, Johanna, McCleland, Mark, Ritorto, Maria Stella, Alessi, Dario R, Trost, Matthias, Bainbridge, Travis W, Kwok, Michael C M, Ma, Taylur P, Stiffler, Zachary, Brasher, Bradley, Tang, Yinyan, Jaishankar, Priyadarshini, Hearn, Brian R, Renslo, Adam R, Arkin, Michelle R, Cohen, Frederick, Yu, Kebing, Peale, Frank, Gnad, Florian, Chang, Matthew T, Klijn, Christiaan, Blackwood, Elizabeth, Martin, Scott E, Forrest, William F, Ernst, James A, Ndubaku, Chudi, Wang, Xiaojing, Beresini, Maureen H, Tsui, Vickie, Schwerdtfeger, Carsten, Blake, Robert A, Murray, Jeremy, Maurer, Till, Wertz, Ingrid E
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
Hewings, David S, Heideker, Johanna, Ma, Taylur P, AhYoung, Andrew P, El Oualid, Farid, Amore, Alessia, Costakes, Gregory T, Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F, Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E
Published in Nature communications (21.03.2018)
Published in Nature communications (21.03.2018)
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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
WERTZ, Ingrid E, KUSAM, Saritha, BELMONT, Lisa D, KAMINKER, Joshua S, O'ROURKE, Karen M, PUJARA, Kanan, BIR KOHLI, Pawan, JOHNSON, Adam R, CHIU, Mark L, LILL, Jennie R, JACKSON, Peter K, FAIRBROTHER, Wayne J, LAM, Cynthia, SESHAGIRI, Somasekar, LUDLAM, Mary J. C, LEONG, Kevin G, DUEBER, Erin C, MAECKER, Heather, HUANG, David C. S, DIXIT, Vishva M, OKAMOTO, Toru, SANDOVAL, Wendy, ANDERSON, Daniel J, HELGASON, Elizabeth, ERNST, James A, EBY, Mike, JINFENG LIU
Published in Nature (London) (03.03.2011)
Published in Nature (London) (03.03.2011)
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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer
Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation
Hong, Seong Ho, Divakaran, Anand, Osa, Akane, Huang, Oscar W., Wertz, Ingrid E., Nomura, Daniel K.
Published in ACS chemical biology (16.02.2024)
Published in ACS chemical biology (16.02.2024)
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Activity‐based probes for the multicatalytic proteasome
Hewings, David S., Flygare, John A., Wertz, Ingrid E., Bogyo, Matthew
Published in The FEBS journal (01.05.2017)
Published in The FEBS journal (01.05.2017)
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