screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects
Bramsen, Jesper B, Pakula, Malgorzata M, Hansen, Thomas B, Bus, Claus, Langkjær, Niels, Odadzic, Dalibor, Smicius, Romualdas, Wengel, Suzy L, Chattopadhyaya, Jyoti, Engels, Joachim W, Herdewijn, Piet, Wengel, Jesper, Kjems, Jørgen
Published in Nucleic acids research (01.09.2010)
Published in Nucleic acids research (01.09.2010)
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Journal Article
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
Laursen, Maria B, Pakula, Malgorzata M, Gao, Shan, Fluiter, Kees, Mook, Olaf R, Baas, Frank, Langklær, Niels, Wengel, Suzy L, Wengel, Jesper, Kjems, Jørgen, Bramsen, Jesper B
Published in Molecular bioSystems (2010)
Published in Molecular bioSystems (2010)
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Journal Article
In vivo efficacy and off-target effects of Locked Nucleic Acid (LNA) and Unlocked Nucleic Acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts
Mook, O.R., Vreijling, Jeroen, Wengel, Suzy, Wengel, Jesper, Zhou, Chuanzheng, Chattopadhyaya, Jyoti, Baas, Frank, Fluiter, Kees
Published in Artificial DNA, PNA & XNA (01.07.2010)
Published in Artificial DNA, PNA & XNA (01.07.2010)
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Journal Article