IgG Conformer's Binding to Amyloidogenic Aggregates
Phay, Monichan, Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Blinder, Veronika, O'Malley, Tiernan T, Solomon, Alan, Walsh, Dominic M, O'Nuallain, Brian
Published in PloS one (14.09.2015)
Published in PloS one (14.09.2015)
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Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide
Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A, Ehrlich, Hartmut J, Schwarz, Hans P, Walsh, Dominic M, Solomon, Alan, O'Nuallain, Brian
Published in PloS one (27.11.2012)
Published in PloS one (27.11.2012)
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The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
Mc Donald, Jessica M., Savva, George M., Brayne, Carol, Welzel, Alfred T., Forster, Gill, Shankar, Ganesh M., Selkoe, Dennis J., Ince, Paul G., Walsh, Dominic M.
Published in Brain (London, England : 1878) (01.05.2010)
Published in Brain (London, England : 1878) (01.05.2010)
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Secreted Amyloid β‑Proteins in a Cell Culture Model Include N‑Terminally Extended Peptides That Impair Synaptic Plasticity
Welzel, Alfred T, Maggio, John E, Shankar, Ganesh M, Walker, Donald E, Ostaszewski, Beth L, Li, Shaomin, Klyubin, Igor, Rowan, Michael J, Seubert, Peter, Walsh, Dominic M, Selkoe, Dennis J
Published in Biochemistry (Easton) (24.06.2014)
Published in Biochemistry (Easton) (24.06.2014)
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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
Klyubin, Igor, Betts, Vicki, Welzel, Alfred T, Blennow, Kaj, Zetterberg, Henrik, Wallin, Anders, Lemere, Cynthia A, Cullen, William K, Peng, Ying, Wisniewski, Thomas, Selkoe, Dennis J, Anwyl, Roger, Walsh, Dominic M, Rowan, Michael J
Published in The Journal of neuroscience (16.04.2008)
Published in The Journal of neuroscience (16.04.2008)
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Cognitive effects of cell-derived and synthetically derived Aβ oligomers
Reed, Miranda N, Hofmeister, Jacki J, Jungbauer, Lisa, Welzel, Alfred T, Yu, Chunjiang, Sherman, Mathew A, Lesné, Sylvain, LaDu, Mary Jo, Walsh, Dominic M, Ashe, Karen H, Cleary, James P
Published in Neurobiology of aging (01.10.2011)
Published in Neurobiology of aging (01.10.2011)
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Substrate-targeting gamma-secretase modulators
Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Published in Nature (London) (12.06.2008)
Published in Nature (London) (12.06.2008)
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Journal Article
Human Anti-A[beta] IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A, Ehrlich, Hartmut J, Schwarz, Hans P, Walsh, Dominic M, Solomon, Alan, O'Nuallain, Brian
Published in PloS one (27.11.2012)
Published in PloS one (27.11.2012)
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Journal Article
IgG Conformer's Binding to Amyloidogenic Aggregates: e0137344
Phay, Monichan, Welzel, Alfred T, Williams, Angela D, McWilliams-Koeppen, Helen P, Blinder, Veronika, Solomon, Alan, Walsh, Dominic M
Published in PloS one (01.09.2015)
Published in PloS one (01.09.2015)
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Substrate-targeting -secretase modulators
Kukar, Thomas L, Golde, Todd E, Ladd, Thomas B, Bann, Maralyssa A, Fraering, Patrick C, Narlawar, Rajeshwar, Maharvi, Ghulam M, Healy, Brent, Chapman, Robert, Welzel, Alfred T, Price, Robert W, Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A, Torpey, Justin, Rosenberry, Terrone L, Fauq, Abdul, Wolfe, Michael S, Schmidt, Boris, Walsh, Dominic M, Koo, Edward H
Published in Nature (London) (12.06.2008)
Published in Nature (London) (12.06.2008)
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Substrate-targeting big gamma-secretase modulators
Kukar, Thomas L, Ladd, Thomas B, Bann, Maralyssa A, Fraering, Patrick C, Narlawar, Rajeshwar, Maharvi, Ghulam M, Healy, Brent, Chapman, Robert, Welzel, Alfred T, Price, Robert W, Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A, Torpey, Justin, Rosenberry, Terrone L, Fauq, Abdul, Wolfe, Michael S, Schmidt, Boris, Walsh, Dominic M, Koo, Edward H, Golde, Todd E
Published in Nature (12.06.2008)
Published in Nature (12.06.2008)
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Journal Article
The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
Mc Donald, Jessica M, Savva, George M, Brayne, Carol, Welzel, Alfred T, Forster, Gill, Shankar, Ganesh M, Selkoe, Dennis J, Ince, Paul G, Walsh, Dominic M
Published in Brain (London, England : 1878) (01.05.2010)
Published in Brain (London, England : 1878) (01.05.2010)
Get full text
Journal Article
Amyloid {beta} Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization
Klyubin, Igor, Betts, Vicki, Welzel, Alfred T, Blennow, Kaj, Zetterberg, Henrik, Wallin, Anders, Lemere, Cynthia A, Cullen, William K, Peng, Ying, Wisniewski, Thomas, Selkoe, Dennis J, Anwyl, Roger, Walsh, Dominic M, Rowan, Michael J
Published in The Journal of neuroscience (16.04.2008)
Published in The Journal of neuroscience (16.04.2008)
Get full text
Journal Article
Secreted Amyloid -Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity
Welzel, Alfred T, Maggio John E.authorDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United StatesDepartment of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, United States, Shankar Ganesh M.authorDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United States, Walker Donald E.authorElan Pharmaceuticals, South San Francisco, California 94080, United States, Ostaszewski Beth L.authorDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United States, Li ShaominauthorDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United States, Klyubin IgorauthorInstitute of Neuroscience and Departments of Pharmacology and Therapeutics, Trinity College, Dublin 2, Republic of Ireland, Rowan Michael J.authorInstitute of Neuroscience and Departments of Pharmacology and Therapeutics, Trinity College, Dublin 2, Republic of Ireland, Seubert PeterauthorElan Pharmaceuticals, South San Francisco, California 94080, United States, Walsh Dominic M.authorLaboratory for Neurodegenerative Research, Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Belfield, Dublin 4, Republic of IrelandDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United States, Selkoe Dennis J.authorDepartment of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Womens Hospital, Boston, Massachusetts 02115, United States
Year of Publication 2015
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Year of Publication 2015
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