TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility
Farmer, Louise K, Rollason, Ruth, Whitcomb, Daniel J, Ni, Lan, Goodliff, Alexander, Lay, Abigail C, Birnbaumer, Lutz, Heesom, Kate J, Xu, Shang-Zhong, Saleem, Moin A, Welsh, Gavin I
Published in Journal of the American Society of Nephrology (01.10.2019)
Published in Journal of the American Society of Nephrology (01.10.2019)
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Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus
Aulicino, Francesco, Pelosse, Martin, Toelzer, Christine, Capin, Julien, Ilegems, Erwin, Meysami, Parisa, Rollarson, Ruth, Berggren, Per-Olof, Dillingham, Mark Simon, Schaffitzel, Christiane, Saleem, Moin A, Welsh, Gavin I, Berger, Imre
Published in Nucleic acids research (22.07.2022)
Published in Nucleic acids research (22.07.2022)
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Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx
Singh, Anurag, Ramnath, Raina D, Foster, Rebecca R, Wylie, Emma C, Fridén, Vincent, Dasgupta, Ishita, Haraldsson, Borje, Welsh, Gavin I, Mathieson, Peter W, Satchell, Simon C
Published in PloS one (14.02.2013)
Published in PloS one (14.02.2013)
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Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management
Bierzynska, Agnieszka, McCarthy, Hugh J., Soderquest, Katrina, Sen, Ethan S., Colby, Elizabeth, Ding, Wen Y., Nabhan, Marwa M., Kerecuk, Larissa, Hegde, Shivram, Hughes, David, Marks, Stephen, Feather, Sally, Jones, Caroline, Webb, Nicholas J.A., Ognjanovic, Milos, Christian, Martin, Gilbert, Rodney D., Sinha, Manish D., Lord, Graham M., Simpson, Michael, Koziell, Ania B., Welsh, Gavin I., Saleem, Moin A.
Published in Kidney international (01.04.2017)
Published in Kidney international (01.04.2017)
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TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways
Dorval, Guillaume, Kuzmuk, Valeryia, Gribouval, Olivier, Welsh, Gavin I., Bierzynska, Agnieszka, Schmitt, Alain, Miserey-Lenkei, Stéphanie, Koziell, Ania, Haq, Shuman, Benmerah, Alexandre, Mollet, Géraldine, Boyer, Olivia, Saleem, Moin A., Antignac, Corinne
Published in American journal of human genetics (07.02.2019)
Published in American journal of human genetics (07.02.2019)
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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice
Qiu, Yan, Buffonge, Stanley, Ramnath, Raina, Jenner, Sophie, Fawaz, Sarah, Arkill, Kenton P., Neal, Chris, Verkade, Paul, White, Stephen J., Hezzell, Melanie, Salmon, Andrew H. J., Suleiman, M.-Saadeh, Welsh, Gavin I., Foster, Rebecca R., Madeddu, Paolo, Satchell, Simon C.
Published in Diabetologia (01.05.2022)
Published in Diabetologia (01.05.2022)
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WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
Amin, Elianna M., Oltean, Sebastian, Hua, Jing, Gammons, Melissa V.R., Hamdollah-Zadeh, Maryam, Welsh, Gavin I., Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S., Symonds, Kirsty E., Nowak, Dawid G., Royer-Pokora, Brigitte, Saleem, Moin A., Hagiwara, Masatoshi, Schumacher, Valérie A., Harper, Steven J., Hinton, David R., Bates, David O., Ladomery, Michael R.
Published in Cancer cell (13.12.2011)
Published in Cancer cell (13.12.2011)
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VEGF regulates local inhibitory complement proteins in the eye and kidney
Keir, Lindsay S, Firth, Rachel, Aponik, Lyndsey, Feitelberg, Daniel, Sakimoto, Susumu, Aguilar, Edith, Welsh, Gavin I, Richards, Anna, Usui, Yoshihiko, Satchell, Simon C, Kuzmuk, Valeryia, Coward, Richard J, Goult, Jonathan, Bull, Katherine R, Sharma, Ruchi, Bharti, Kapil, Westenskow, Peter D, Michael, Iacovos P, Saleem, Moin A, Friedlander, Martin
Published in The Journal of clinical investigation (01.01.2017)
Published in The Journal of clinical investigation (01.01.2017)
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Genome editing and kidney health
Tavakolidakhrabadi, Nadia, Aulicino, Francesco, May, Carl J, Saleem, Moin A, Berger, Imre, Welsh, Gavin I
Published in Clinical kidney journal (01.05.2024)
Published in Clinical kidney journal (01.05.2024)
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Human Th17 cells produce a soluble mediator that increases podocyte motility via signaling pathways that mimic PAR-1 activation
May, Carl J, Welsh, Gavin I, Chesor, Musleeha, Lait, Phillipa J, Schewitz-Bowers, Lauren P, Lee, Richard W J, Saleem, Moin A
Published in American journal of physiology. Renal physiology (01.10.2019)
Published in American journal of physiology. Renal physiology (01.10.2019)
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The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease
Finch, Natalie C, Neal, Chris R, Welsh, Gavin I, Foster, Rebecca R, Satchell, Simon C
Published in American journal of physiology. Renal physiology (01.10.2023)
Published in American journal of physiology. Renal physiology (01.10.2023)
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Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations
Sen, Ethan S, Dean, Philip, Yarram-Smith, Laura, Bierzynska, Agnieszka, Woodward, Geoff, Buxton, Chris, Dennis, Gemma, Welsh, Gavin I, Williams, Maggie, Saleem, Moin A
Published in Journal of medical genetics (01.12.2017)
Published in Journal of medical genetics (01.12.2017)
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Differential Expression of VEGF-Axxx Isoforms Is Critical for Development of Pulmonary Fibrosis
Barratt, Shaney L, Blythe, Thomas, Jarrett, Caroline, Ourradi, Khadija, Shelley-Fraser, Golda, Day, Michael J, Qiu, Yan, Harper, Steve, Maher, Toby M, Oltean, Sebastian, Hames, Thomas J, Scotton, Chris J, Welsh, Gavin I, Bates, David O, Millar, Ann B
Published in American journal of respiratory and critical care medicine (15.08.2017)
Published in American journal of respiratory and critical care medicine (15.08.2017)
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VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy
Onions, Karen L, Gamez, Monica, Buckner, Nicola R, Baker, Siân L, Betteridge, Kai B, Desideri, Sara, Dallyn, Benjamin P, Ramnath, Raina D, Neal, Chris R, Farmer, Louise K, Mathieson, Peter W, Gnudi, Luigi, Alitalo, Kari, Bates, David O, Salmon, Andrew H J, Welsh, Gavin I, Satchell, Simon C, Foster, Rebecca R
Published in Diabetes (New York, N.Y.) (01.01.2019)
Published in Diabetes (New York, N.Y.) (01.01.2019)
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Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model
Bierzynska, Agnieszka, Bull, Katherine, Miellet, Sara, Dean, Philip, Neal, Chris, Colby, Elizabeth, McCarthy, Hugh J., Hegde, Shivaram, Sinha, Manish D., Bugarin Diz, Carmen, Stirrups, Kathleen, Megy, Karyn, Mapeta, Rutendo, Penkett, Chris, Marsh, Sarah, Forrester, Natalie, Afzal, Maryam, Stark, Hannah, BioResource, NIHR, Williams, Maggie, Welsh, Gavin I., Koziell, Ania B., Hartley, Paul S., Saleem, Moin A.
Published in Pediatric nephrology (Berlin, West) (01.11.2022)
Published in Pediatric nephrology (Berlin, West) (01.11.2022)
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Aldosterone induces albuminuria via matrix metalloproteinase–dependent damage of the endothelial glycocalyx
Butler, Matthew J., Ramnath, Raina, Kadoya, Hiroyuki, Desposito, Dorinne, Riquier-Brison, Anne, Ferguson, Joanne K., Onions, Karen L., Ogier, Anna S., ElHegni, Hesham, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Peti-Peterdi, Janos, Satchell, Simon C.
Published in Kidney international (01.01.2019)
Published in Kidney international (01.01.2019)
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Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease
Ramnath, Raina D., Butler, Matthew J., Newman, Georgina, Desideri, Sara, Russell, Amy, Lay, Abigail C., Neal, Chris R., Qiu, Yan, Fawaz, Sarah, Onions, Karen L., Gamez, Monica, Crompton, Michael, Michie, Chris, Finch, Natalie, Coward, Richard J., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C.
Published in Kidney international (01.05.2020)
Published in Kidney international (01.05.2020)
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