First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study
Sullivan, Ryan J, Infante, Jeffrey R, Janku, Filip, Wong, Deborah Jean Lee, Sosman, Jeffrey A, Keedy, Vicki, Patel, Manish R, Shapiro, Geoffrey I, Mier, James W, Tolcher, Anthony W, Wang-Gillam, Andrea, Sznol, Mario, Flaherty, Keith, Buchbinder, Elizabeth, Carvajal, Richard D, Varghese, Anna M, Lacouture, Mario E, Ribas, Antoni, Patel, Sapna P, DeCrescenzo, Gary A, Emery, Caroline M, Groover, Anna L, Saha, Saurabh, Varterasian, Mary, Welsch, Dean J, Hyman, David M, Li, Bob T
Published in Cancer discovery (01.02.2018)
Published in Cancer discovery (01.02.2018)
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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)
Germann, Ursula A, Furey, Brinley F, Markland, William, Hoover, Russell R, Aronov, Alex M, Roix, Jeffrey J, Hale, Michael, Boucher, Diane M, Sorrell, David A, Martinez-Botella, Gabriel, Fitzgibbon, Matthew, Shapiro, Paul, Wick, Michael J, Samadani, Ramin, Meshaw, Kathryn, Groover, Anna, DeCrescenzo, Gary, Namchuk, Mark, Emery, Caroline M, Saha, Saurabh, Welsch, Dean J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Aguirre, Andrew J, Nowak, Jonathan A, Camarda, Nicholas D, Moffitt, Richard A, Ghazani, Arezou A, Hazar-Rethinam, Mehlika, Raghavan, Srivatsan, Kim, Jaegil, Brais, Lauren K, Ragon, Dorisanne, Welch, Marisa W, Reilly, Emma, McCabe, Devin, Marini, Lori, Anderka, Kristin, Helvie, Karla, Oliver, Nelly, Babic, Ana, Da Silva, Annacarolina, Nadres, Brandon, Van Seventer, Emily E, Shahzade, Heather A, St Pierre, Joseph P, Burke, Kelly P, Clancy, Thomas, Cleary, James M, Doyle, Leona A, Jajoo, Kunal, McCleary, Nadine J, Meyerhardt, Jeffrey A, Murphy, Janet E, Ng, Kimmie, Patel, Anuj K, Perez, Kimberly, Rosenthal, Michael H, Rubinson, Douglas A, Ryou, Marvin, Shapiro, Geoffrey I, Sicinska, Ewa, Silverman, Stuart G, Nagy, Rebecca J, Lanman, Richard B, Knoerzer, Deborah, Welsch, Dean J, Yurgelun, Matthew B, Fuchs, Charles S, Garraway, Levi A, Getz, Gad, Hornick, Jason L, Johnson, Bruce E, Kulke, Matthew H, Mayer, Robert J, Miller, Jeffrey W, Shyn, Paul B, Tuveson, David A, Wagle, Nikhil, Yeh, Jen Jen, Hahn, William C, Corcoran, Ryan B, Carter, Scott L, Wolpin, Brian M
Published in Cancer discovery (01.09.2018)
Published in Cancer discovery (01.09.2018)
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Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
Willette, Robert N, Mangrolia, Parth, Pondell, Stephen M, Lee, Christopher Young Woo, Yoo, Sanghee, Rudoltz, Marc S, Cowen, Benjamin R, Welsch, Dean J
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2021)
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Metalloproteases and inhibitors in arthritic diseases
Martel-Pelletier, Johanne, Welsch, Dean J., Pelletier, Jean-Pierre
Published in Best practice & research. Clinical rheumatology (01.12.2001)
Published in Best practice & research. Clinical rheumatology (01.12.2001)
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The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms
Hultman, Monica L, Krasnoperova, Nataliia V, Li, Suzhen, Du, Sarah, Xia, Chunsheng, Dietz, Jessica D, Lala, Deepak S, Welsch, Dean J, Hu, Xiao
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2005)
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2005)
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Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)
Carron, Chris P, Trujillo, John I, Olson, Kirk L, Huang, Wei, Hamper, Bruce C, Dice, Tom, Neal, Bradley E, Pelc, Matthew J, Day, Jacqueline E, Rohrer, Douglas C, Kiefer, James R, Moon, Joseph B, Schweitzer, Barbara A, Blake, Tanisha D, Turner, Steve R, Woerndle, Rhonda, Case, Brenda L, Bono, Christine P, Dilworth, Vickie M, Funckes-Shippy, Christie L, Hood, Becky L, Jerome, Gina M, Kornmeier, Christine M, Radabaugh, Melissa R, Williams, Melanie L, Davies, Michael S, Wegner, Craig D, Welsch, Dean J, Abraham, William M, Warren, Chad J, Dowty, Martin E, Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z, Thorarensen, Atli
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Abstract 4693: The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance
Germann, Ursula, Furey, Brinley, Roix, Jeff, Markland, William, Hoover, Russell, Aronov, Alex, Hale, Michael, Chen, Guanjing, Martinez-Botella, Gabriel, Alargova, Rossitza, Fan, Bin, Sorrell, David, Meshaw, Kay, Shapiro, Paul, Wick, Michael J., Benes, Cyril, Garnett, Mathew, DeCrescenzo, Gary, Namchuk, Mark, Saha, Saurabh, Welsch, Dean J.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Dose escalation stage of a first-in-class phase I study of the novel oral ERK 1/2 kinase inhibitor BVD-523 (ulixertinib) in patients with advanced solid tumors
Infante, Jeffrey R., Janku, Filip, Tolcher, Anthony W., Patel, Manish R., Sullivan, Ryan J., Flaherty, Keith, Carvajal, Richard D., Varghese, Anna M., Wong, Deborah Jean Lee, Sznol, Mario, Sosman, Jeffrey Alan, Wang-Gillam, Andrea, Burris, Howard A., Ribas, Antoni, Patel, Sapna Pradyuman, Welsch, Dean J., Saha, Saurabh
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Molecular cloning and expression of human leukotriene-C4 synthase
Welsch, D J, Creely, D P, Hauser, S D, Mathis, K J, Krivi, G G, Isakson, P C
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.1994)
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.1994)
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