K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Ostrem, Jonathan M, Peters, Ulf, Sos, Martin L, Wells, James A, Shokat, Kevan M
Published in Nature (London) (29.11.2013)
Published in Nature (London) (29.11.2013)
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Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
Ordureau, Alban, Sarraf, Shireen A., Duda, David M., Heo, Jin-Mi, Jedrychowski, Mark P., Sviderskiy, Vladislav O., Olszewski, Jennifer L., Koerber, James T., Xie, Tiao, Beausoleil, Sean A., Wells, James A., Gygi, Steven P., Schulman, Brenda A., Harper, J. Wade
Published in Molecular cell (06.11.2014)
Published in Molecular cell (06.11.2014)
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Journal Article
Redox-based reagents for chemoselective methionine bioconjugation
Lin, Shixian, Yang, Xiaoyu, Jia, Shang, Weeks, Amy M., Hornsby, Michael, Lee, Peter S., Nichiporuk, Rita V., Iavarone, Anthony T., Wells, James A., Toste, F. Dean, Chang, Christopher J.
Published in Science (American Association for the Advancement of Science) (10.02.2017)
Published in Science (American Association for the Advancement of Science) (10.02.2017)
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Journal Article
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Lim, Shion A., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2020)
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Journal Article
Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator
Zhuang, Min, Guan, Shenheng, Wang, Haopeng, Burlingame, Alma L., Wells, James A.
Published in Molecular cell (24.01.2013)
Published in Molecular cell (24.01.2013)
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Journal Article
Sampling the N-terminal proteome of human blood
Wildes, David, Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2010)
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Journal Article
A reactivity-based probe of the intracellular labile ferrous iron pool
Spangler, Benjamin, Morgan, Charles W, Fontaine, Shaun D, Vander Wal, Mark N, Chang, Christopher J, Wells, James A, Renslo, Adam R
Published in Nature chemical biology (01.09.2016)
Published in Nature chemical biology (01.09.2016)
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Journal Article
CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites
Cimermancic, Peter, Weinkam, Patrick, Rettenmaier, T. Justin, Bichmann, Leon, Keedy, Daniel A., Woldeyes, Rahel A., Schneidman-Duhovny, Dina, Demerdash, Omar N., Mitchell, Julie C., Wells, James A., Fraser, James S., Sali, Andrej
Published in Journal of molecular biology (22.02.2016)
Published in Journal of molecular biology (22.02.2016)
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Journal Article
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Julien, Olivier, Zhuang, Min, Wiita, Arun P., O’Donoghue, Anthony J., Knudsen, Giselle M., Craik, Charles S., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
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Journal Article
Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity
Nguyen, Duy P, Miyaoka, Yuichiro, Gilbert, Luke A, Mayerl, Steven J, Lee, Brian H, Weissman, Jonathan S, Conklin, Bruce R, Wells, James A
Published in Nature communications (01.07.2016)
Published in Nature communications (01.07.2016)
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Journal Article
Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation
Elledge, Susanna K., Tran, Hai L., Christian, Alec H., Steri, Veronica, Hann, Byron, Toste, F. Dean, Chang, Christopher J., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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Journal Article
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries
Zhou, Jie, Li, Shantao, Leung, Kevin K., O’Donovan, Brian, Zou, James Y., DeRisi, Joseph L., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (13.10.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (13.10.2020)
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Journal Article
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S
Published in eLife (07.06.2018)
Published in eLife (07.06.2018)
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Journal Article
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
Muller, Yannick D, Nguyen, Duy P, Ferreira, Leonardo M R, Ho, Patrick, Raffin, Caroline, Valencia, Roxxana Valeria Beltran, Congrave-Wilson, Zion, Roth, Theodore L, Eyquem, Justin, Van Gool, Frederic, Marson, Alexander, Perez, Laurent, Wells, James A, Bluestone, Jeffrey A, Tang, Qizhi
Published in Frontiers in immunology (23.03.2021)
Published in Frontiers in immunology (23.03.2021)
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Journal Article
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
Ferguson, Ian D, Patiño-Escobar, Bonell, Tuomivaara, Sami T, Lin, Yu-Hsiu T, Nix, Matthew A, Leung, Kevin K, Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W, Wolf, Jeffrey L, Martin, 3rd, Thomas G, Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Jr, Avery D, Mullins, R Dyche, Eyquem, Justin, Wells, James A, Wiita, Arun P
Published in Nature communications (15.07.2022)
Published in Nature communications (15.07.2022)
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