Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Maffioletti, Sara Martina, Sarcar, Shilpita, Henderson, Alexander B.H., Mannhardt, Ingra, Pinton, Luca, Moyle, Louise Anne, Steele-Stallard, Heather, Cappellari, Ornella, Wells, Kim E., Ferrari, Giulia, Mitchell, Jamie S., Tyzack, Giulia E., Kotiadis, Vassilios N., Khedr, Moustafa, Ragazzi, Martina, Wang, Weixin, Duchen, Michael R., Patani, Rickie, Zammit, Peter S., Wells, Dominic J., Eschenhagen, Thomas, Tedesco, Francesco Saverio
Published in Cell reports (Cambridge) (17.04.2018)
Published in Cell reports (Cambridge) (17.04.2018)
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Journal Article
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
Cirak, Sebahattin, MD, Arechavala-Gomeza, Virginia, PhD, Guglieri, Michela, MD, Feng, Lucy, PhD, Torelli, Silvia, PhD, Anthony, Karen, PhD, Abbs, Stephen, PhD, Garralda, Maria Elena, Prof, Bourke, John, MD, Wells, Dominic J, Prof, Dickson, George, Prof, Wood, Matthew JA, MD PhD, Wilton, Steve D, Prof, Straub, Volker, Prof, Kole, Ryszard, Prof, Shrewsbury, Stephen B, MD, Sewry, Caroline, Prof, Morgan, Jennifer E, PhD, Bushby, Kate, Prof, Muntoni, Francesco, Prof
Published in The Lancet (British edition) (13.08.2011)
Published in The Lancet (British edition) (13.08.2011)
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Journal Article
Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb
Charles, James P, Cappellari, Ornella, Spence, Andrew J, Hutchinson, John R, Wells, Dominic J
Published in PloS one (26.04.2016)
Published in PloS one (26.04.2016)
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Journal Article
Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study
Kinali, Maria, MD, Arechavala-Gomeza, Virginia, PhD, Feng, Lucy, PhD, Cirak, Sebahattin, MD, Hunt, David, FRCS, Adkin, Carl, PhD, Guglieri, Michela, MD, Ashton, Emma, PhD, Abbs, Stephen, PhD, Nihoyannopoulos, Petros, MD, Garralda, Maria Elena, MD, Rutherford, Mary, MD, Mcculley, Caroline, PhD, Popplewell, Linda, PhD, Graham, Ian R, PhD, Dickson, George, PhD, Wood, Matthew JA, MD, Wells, Dominic J, PhD, Wilton, Steve D, PhD, Kole, Ryszard, PhD, Straub, Volker, MD, Bushby, Kate, MD, Sewry, Caroline, PhD, Morgan, Jennifer E, PhD, Muntoni, Francesco, MD
Published in Lancet neurology (01.10.2009)
Published in Lancet neurology (01.10.2009)
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Journal Article
Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
Hildyard, John C W, Rawson, Faye, Wells, Dominic J, Piercy, Richard J
Published in PloS one (24.09.2020)
Published in PloS one (24.09.2020)
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Journal Article
Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy
Riddell, Dominique O, Hildyard, John C W, Harron, Rachel C M, Hornby, Natasha L, Wells, Dominic J, Piercy, Richard J
Published in Disease models & mechanisms (01.12.2022)
Published in Disease models & mechanisms (01.12.2022)
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Journal Article
Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne muscular dystrophy
Riddell, Dominique O, Hildyard, John C W, Harron, Rachel C M, Taylor-Brown, Frances, Kornegay, Joe N, Wells, Dominic J, Piercy, Richard J
Published in Disease models & mechanisms (01.12.2023)
Published in Disease models & mechanisms (01.12.2023)
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Journal Article
Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)
Willmann, Raffaella, Lee, Joanne, Turner, Cathy, Nagaraju, Kanneboyina, Aartsma-Rus, Annemieke, Wells, Dominic J, Wagner, Kathryn R, Csimma, Cristina, Straub, Volker, Grounds, Miranda D, De Luca, Annamaria
Published in Disease models & mechanisms (07.02.2020)
Published in Disease models & mechanisms (07.02.2020)
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Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
Kondori, Nazanin Rahmani, Paul, Praveen, Robbins, Jacqueline P, Liu, Ke, Hildyard, John C W, Wells, Dominic J, de Belleroche, Jacqueline S
Published in PloS one (01.12.2017)
Published in PloS one (01.12.2017)
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Journal Article
Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
Rayner, Katey, Chen, Yong-Xiang, McNulty, Melissa, Simard, Trevor, Zhao, Xioaling, Wells, Dominic J, de Belleroche, Jacqueline, O’Brien, Edward R
Published in Circulation research (18.07.2008)
Published in Circulation research (18.07.2008)
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Journal Article
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice
Whitmore, Charlotte, Fernandez-Fuente, Marta, Booler, Helen, Parr, Callum, Kavishwar, Manoli, Ashraf, Attia, Lacey, Erica, Kim, Jihee, Terry, Rebecca, Ackroyd, Mark R, Wells, Kim E, Muntoni, Francesco, Wells, Dominic J, Brown, Susan C
Published in Human molecular genetics (01.04.2014)
Published in Human molecular genetics (01.04.2014)
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Journal Article
Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer
Foster, Helen, Sharp, Paul S, Athanasopoulos, Takis, Trollet, Capucine, Graham, Ian R, Foster, Keith, Wells, Dominic J, Dickson, George
Published in Molecular therapy (01.11.2008)
Published in Molecular therapy (01.11.2008)
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