Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
Karikó, Katalin, Muramatsu, Hiromi, Ludwig, János, Weissman, Drew
Published in Nucleic acids research (01.11.2011)
Published in Nucleic acids research (01.11.2011)
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Tuberculosis and lung damage: from epidemiology to pathophysiology
Ravimohan, Shruthi, Kornfeld, Hardy, Weissman, Drew, Bisson, Gregory P
Published in European respiratory review (31.03.2018)
Published in European respiratory review (31.03.2018)
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Journal Article
An ionizable lipid toolbox for RNA delivery
Han, Xuexiang, Zhang, Hanwen, Butowska, Kamila, Swingle, Kelsey L., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Published in Nature communications (13.12.2021)
Published in Nature communications (13.12.2021)
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Journal Article
Nanomaterial Delivery Systems for mRNA Vaccines
Buschmann, Michael D, Carrasco, Manuel J, Alishetty, Suman, Paige, Mikell, Alameh, Mohamad Gabriel, Weissman, Drew
Published in Vaccines (Basel) (19.01.2021)
Published in Vaccines (Basel) (19.01.2021)
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Journal Article
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
Shepherd, Sarah J, Warzecha, Claude C, Yadavali, Sagar, El-Mayta, Rakan, Alameh, Mohamad-Gabriel, Wang, Lili, Weissman, Drew, Wilson, James M, Issadore, David, Mitchell, Michael J
Published in Nano letters (14.07.2021)
Published in Nano letters (14.07.2021)
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Journal Article
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew
Published in Journal of controlled release (10.11.2015)
Published in Journal of controlled release (10.11.2015)
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Journal Article
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
Rothgangl, Tanja, Dennis, Melissa K., Lin, Paulo J. C., Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A., Kadina, Anastasia P., Victorov, Denis V., Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K., Semple, Sean C., Schwank, Gerald
Published in Nature biotechnology (01.08.2021)
Published in Nature biotechnology (01.08.2021)
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Journal Article
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
Weissman, Drew, Alameh, Mohamad-Gabriel, de Silva, Thushan, Collini, Paul, Hornsby, Hailey, Brown, Rebecca, LaBranche, Celia C., Edwards, Robert J., Sutherland, Laura, Santra, Sampa, Mansouri, Katayoun, Gobeil, Sophie, McDanal, Charlene, Pardi, Norbert, Hengartner, Nick, Lin, Paulo J.C., Tam, Ying, Shaw, Pamela A., Lewis, Mark G., Boesler, Carsten, Şahin, Uğur, Acharya, Priyamvada, Haynes, Barton F., Korber, Bette, Montefiori, David C.
Published in Cell Host & Microbe (13.01.2021)
Published in Cell Host & Microbe (13.01.2021)
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Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
Han, Xuexiang, Gong, Ningqiang, Xue, Lulu, Billingsley, Margaret M., El-Mayta, Rakan, Shepherd, Sarah J., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Published in Nature communications (17.01.2023)
Published in Nature communications (17.01.2023)
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Journal Article
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew
Published in Nature (London) (09.03.2017)
Published in Nature (London) (09.03.2017)
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Journal Article
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
Martinez, David R, Schäfer, Alexandra, Leist, Sarah R, De la Cruz, Gabriela, West, Ande, Atochina-Vasserman, Elena N, Lindesmith, Lisa C, Pardi, Norbert, Parks, Robert, Barr, Maggie, Li, Dapeng, Yount, Boyd, Saunders, Kevin O, Weissman, Drew, Haynes, Barton F, Montgomery, Stephanie A, Baric, Ralph S
Published in Science (27.08.2021)
Published in Science (27.08.2021)
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Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
Rizvi, Fatima, Everton, Elissa, Smith, Anna R., Liu, Hua, Osota, Elizabeth, Beattie, Mitchell, Tam, Ying, Pardi, Norbert, Weissman, Drew, Gouon-Evans, Valerie
Published in Nature communications (27.01.2021)
Published in Nature communications (27.01.2021)
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Journal Article
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
Zhang, Dapeng, Atochina-Vasserman, Elena N, Lu, Juncheng, Maurya, Devendra S, Xiao, Qi, Liu, Matthew, Adamson, Jasper, Ona, Nathan, Reagan, Erin K, Ni, Houping, Weissman, Drew, Percec, Virgil
Published in Journal of the American Chemical Society (23.03.2022)
Published in Journal of the American Chemical Society (23.03.2022)
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Journal Article
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
Pardi, Norbert, Parkhouse, Kaela, Kirkpatrick, Ericka, McMahon, Meagan, Zost, Seth J., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Krammer, Florian, Hensley, Scott E., Weissman, Drew
Published in Nature communications (22.08.2018)
Published in Nature communications (22.08.2018)
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Journal Article
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew
Published in Nature communications (02.03.2017)
Published in Nature communications (02.03.2017)
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Journal Article
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.
Published in Journal of controlled release (10.12.2018)
Published in Journal of controlled release (10.12.2018)
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Journal Article
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
Carrasco, Manuel J., Alishetty, Suman, Alameh, Mohamad-Gabriel, Said, Hooda, Wright, Lacey, Paige, Mikell, Soliman, Ousamah, Weissman, Drew, Cleveland, Thomas E., Grishaev, Alexander, Buschmann, Michael D.
Published in Communications biology (11.08.2021)
Published in Communications biology (11.08.2021)
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Journal Article
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)
Parhiz, Hamideh, Brenner, Jacob S., Patel, Priyal N., Papp, Tyler E., Shahnawaz, Hamna, Li, Qin, Shi, Ruiqi, Zamora, Marco E., Yadegari, Amir, Marcos-Contreras, Oscar A., Natesan, Ambika, Pardi, Norbert, Shuvaev, Vladimir V., Kiseleva, Raisa, Myerson, Jacob W., Uhler, Thomas, Riley, Rachel S., Han, Xuexiang, Mitchell, Michael J., Lam, Kieu, Heyes, James, Weissman, Drew, Muzykantov, Vladimir R.
Published in Journal of controlled release (01.04.2022)
Published in Journal of controlled release (01.04.2022)
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Journal Article
An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection
Egan, Kevin P, Hook, Lauren M, Naughton, Alexis, Pardi, Norbert, Awasthi, Sita, Cohen, Gary H, Weissman, Drew, Friedman, Harvey M
Published in PLoS pathogens (01.07.2020)
Published in PLoS pathogens (01.07.2020)
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