Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models
Bahreini, Amir, Li, Zheqi, Wang, Peilu, Levine, Kevin M, Tasdemir, Nilgun, Cao, Lan, Weir, Hazel M, Puhalla, Shannon L, Davidson, Nancy E, Stern, Andrew M, Chu, David, Park, Ben Ho, Lee, Adrian V, Oesterreich, Steffi
Published in Breast cancer research : BCR (23.05.2017)
Published in Breast cancer research : BCR (23.05.2017)
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MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo
Jenkins, David W, Ross, Sarah, Veldman-Jones, Margaret, Foltz, Ian N, Clavette, Brandon C, Manchulenko, Kathy, Eberlein, Cath, Kendrew, Jane, Petteruti, Philip, Cho, Song, Damschroder, Melissa, Peng, Li, Baker, Dawn, Smith, Neil R, Weir, Hazel M, Blakey, David C, Bedian, Vahe, Barry, Simon T
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris
Published in Cancer research (Chicago, Ill.) (01.06.2016)
Published in Cancer research (Chicago, Ill.) (01.06.2016)
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A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER + /HER2 - Advanced Breast Cancer
Hamilton, Erika P, Patel, Manish R, Armstrong, Anne C, Baird, Richard D, Jhaveri, Komal, Hoch, Matthias, Klinowska, Teresa, Lindemann, Justin P O, Morgan, Shethah R, Schiavon, Gaia, Weir, Hazel M, Im, Seock-Ah
Published in Clinical cancer research (01.08.2018)
Published in Clinical cancer research (01.08.2018)
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Optimization of a Novel Binding Motif to (E)‑3-(3,5-Difluoro-4-((1R,3R)‑2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro‑1H‑pyrido[3,4‑b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
De Savi, Chris, Bradbury, Robert H, Rabow, Alfred A, Norman, Richard A, de Almeida, Camila, Andrews, David M, Ballard, Peter, Buttar, David, Callis, Rowena J, Currie, Gordon S, Curwen, Jon O, Davies, Chris D, Donald, Craig S, Feron, Lyman J. L, Gingell, Helen, Glossop, Steven C, Hayter, Barry R, Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G, MacFaul, Philip, Moss, Thomas A, Pearson, Stuart E, Tonge, Michael, Walker, Graeme E, Weir, Hazel M, Wilson, Zena
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations
Ladd, Brendon, Mazzola, Anne Marie, Bihani, Teeru, Lai, Zhongwu, Bradford, James, Collins, Michael, Barry, Evan, Goeppert, Anne U, Weir, Hazel M, Hearne, Kelly, Renshaw, Jonathan G, Mohseni, Morvarid, Hurt, Elaine, Jalla, Sanjoo, Bao, Haifeng, Hollingsworth, Robert, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M
Published in Oncotarget (23.08.2016)
Published in Oncotarget (23.08.2016)
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An antibody targeted to VEGFR-2 Ig domains 4-7 inhibits VEGFR-2 activation and VEGFR-2-dependent angiogenesis without affecting ligand binding
Kendrew, Jane, Eberlein, Cath, Hedberg, Brad, McDaid, Karen, Smith, Neil R, Weir, Hazel M, Wedge, Stephen R, Blakey, David C, Foltz, Ian, Zhou, Joe, Kang, Jaspal S, Barry, Simon T
Published in Molecular cancer therapeutics (01.05.2011)
Published in Molecular cancer therapeutics (01.05.2011)
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Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors
Jones, Clifford D., Andrews, David M., Barker, Andrew J., Blades, Kevin, Byth, Kate F., Finlay, M. Raymond V., Geh, Catherine, Green, Clive P., Johannsen, Marie, Walker, Mike, Weir, Hazel M.
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Finlay, M. Raymond V., Acton, David G., Andrews, David M., Barker, Andrew J., Dennis, Michael, Fisher, Eric, Graham, Mark A., Green, Clive P., Heaton, David W., Karoutchi, Galith, Loddick, Sarah A., Morgentin, Rémy, Roberts, Andrew, Tucker, Julie A., Weir, Hazel M.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors
Anderson, Malcolm, Andrews, David M., Barker, Andy J., Brassington, Claire A., Breed, Jason, Byth, Kate F., Culshaw, Janet D., Finlay, M. Raymond V., Fisher, Eric, McMiken, Helen H.J., Green, Clive P., Heaton, Dave W., Nash, Ian A., Newcombe, Nicholas J., Oakes, Sandra E., Pauptit, Richard A., Roberts, Andrew, Stanway, Judith J., Thomas, Andrew P., Tucker, Julie A., Walker, Mike, Weir, Hazel M.
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
De Savi, Chris, Bradbury, Robert H., Rabow, Alfred A., Norman, Richard A., de Almeida, Camila, Andrews, David M., Ballard, Peter, Buttar, David, Callis, Rowena J., Currie, Gordon S., Curwen, Jon O., Davies, Chris D., Donald, Craig S., Feron, Lyman J. L., Gingell, Helen, Glossop, Steven C., Hayter, Barry R., Hussain, Syeed, Karoutchi, Galith, Lamont, Scott G., MacFaul, Philip, Moss, Thomas A., Pearson, Stuart E., Tonge, Michael, Walker, Graeme E., Weir, Hazel M., Wilson, Zena
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Structure of the HMG box motif in the B‐domain of HMG1
Weir, H.M., Kraulis, P.J., Hill, C.S., Raine, A.R., Laue, E.D., Thomas, J.O.
Published in The EMBO journal (01.04.1993)
Published in The EMBO journal (01.04.1993)
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