Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
Moraga, Ignacio, Wernig, Gerlinde, Wilmes, Stephan, Gryshkova, Vitalina, Richter, Christian P., Hong, Wan-Jen, Sinha, Rahul, Guo, Feng, Fabionar, Hyna, Wehrman, Tom S., Krutzik, Peter, Demharter, Samuel, Plo, Isabelle, Weissman, Irving L., Minary, Peter, Majeti, Ravindra, Constantinescu, Stefan N., Piehler, Jacob, Garcia, K. Christopher
Published in Cell (12.03.2015)
Published in Cell (12.03.2015)
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Journal Article
Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor
Burford, Neil T., Clark, Mary J., Wehrman, Tom S., Gerritz, Samuel W., Banks, Martyn, O'Connell, Jonathan, Traynor, John R., Alt, Andrew
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
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Journal Article
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling
Ho, Chia Chi M., Chhabra, Akanksha, Starkl, Philipp, Schnorr, Peter-John, Wilmes, Stephan, Moraga, Ignacio, Kwon, Hye-Sook, Gaudenzio, Nicolas, Sibilano, Riccardo, Wehrman, Tom S., Gakovic, Milica, Sockolosky, Jonathan T., Tiffany, Matthew R., Ring, Aaron M., Piehler, Jacob, Weissman, Irving L., Galli, Stephen J., Shizuru, Judith A., Garcia, K. Christopher
Published in Cell (09.03.2017)
Published in Cell (09.03.2017)
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Journal Article
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers
Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher
Published in eLife (12.05.2017)
Published in eLife (12.05.2017)
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Journal Article
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors
Southern, Craig, Cook, Jennifer M, Neetoo-Isseljee, Zaynab, Taylor, Debra L, Kettleborough, Catherine A, Merritt, Andy, Bassoni, Daniel L, Raab, William J, Quinn, Elizabeth, Wehrman, Tom S, Davenport, Anthony P, Brown, Andrew J, Green, Andrew, Wigglesworth, Mark J, Rees, Steve
Published in Journal of biomolecular screening (01.06.2013)
Published in Journal of biomolecular screening (01.06.2013)
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Journal Article
Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor
Burford, Neil T, Livingston, Kathryn E, Canals, Meritxell, Ryan, Molly R, Budenholzer, Lauren M. L, Han, Ying, Shang, Yi, Herbst, John J, O’Connell, Jonathan, Banks, Martyn, Zhang, Litao, Filizola, Marta, Bassoni, Daniel L, Wehrman, Tom S, Christopoulos, Arthur, Traynor, John R, Gerritz, Samuel W, Alt, Andrew
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Journal Article
Restriction enzyme-generated siRNA (REGS) vectors and libraries
Blau, Helen M, Sen, George, Wehrman, Tom S, Myers, Jason W
Published in Nature genetics (01.02.2004)
Published in Nature genetics (01.02.2004)
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Journal Article
Enzymatic detection of protein translocation
Blau, Helen M, Wehrman, Tom S, Casipit, Clayton L, Gewertz, Nevin M
Published in Nature methods (01.07.2005)
Published in Nature methods (01.07.2005)
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Journal Article
Abstract 2496: Defining the cell surface landscape in cancer: Comprehensive profiling of surface antigens for biomarker discovery and immune monitoring
O'Donnell, Erika A., Alvendia, Erica L., Osetek, Benjamin E., Wehrman, Tom S., Krutzik, Peter O.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 5385: A novel cell-based kinase assay panel paired with high content phenotypic profiling to correlate kinase inhibitor specificity and cellular activity
Wehrman, Tom S., O'Donnell, Erika A., Lumpe, M. Jared, Osetek, Benjamin E., Krutzik, Peter O.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Discovery of positive allosteric modulators and silent allosteric modulators of the [mu]-opioid receptor
Burford, Neil T, Clark, Mary J, Wehrman, Tom S, Gerritz, Samuel W, Banks, Martyn, Connell, Jonathan O, Traynor, John R, Alt, Andrew
Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
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Published in Proceedings of the National Academy of Sciences - PNAS (25.06.2013)
Journal Article