Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
Hernández-Vega, Amayra, Braun, Marcus, Scharrel, Lara, Jahnel, Marcus, Wegmann, Susanne, Hyman, Bradley T., Alberti, Simon, Diez, Stefan, Hyman, Anthony A.
Published in Cell reports (Cambridge) (05.09.2017)
Published in Cell reports (Cambridge) (05.09.2017)
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Journal Article
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero, Benjamin, Bourdenx, Mathieu, Luengo, Enrique, Diaz, Antonio, Sohn, Peter Dongmin, Chen, Xu, Wang, Chao, Juste, Yves R., Wegmann, Susanne, Patel, Bindi, Young, Zapporah T., Kuo, Szu Yu, Rodriguez-Navarro, Jose Antonio, Shao, Hao, Lopez, Manuela G., Karch, Celeste M., Goate, Alison M., Gestwicki, Jason E., Hyman, Bradley T., Gan, Li, Cuervo, Ana Maria
Published in Nature communications (14.04.2021)
Published in Nature communications (14.04.2021)
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Journal Article
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.
Published in Nature communications (13.10.2015)
Published in Nature communications (13.10.2015)
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Journal Article
Formation, release, and internalization of stable tau oligomers in cells
Wegmann, Susanne, Nicholls, Samantha, Takeda, Shuko, Fan, Zhanyun, Hyman, Bradley T.
Published in Journal of neurochemistry (01.12.2016)
Published in Journal of neurochemistry (01.12.2016)
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Journal Article
Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
Tepper, Katharina, Biernat, Jacek, Kumar, Satish, Wegmann, Susanne, Timm, Thomas, Hübschmann, Sabrina, Redecke, Lars, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Published in The Journal of biological chemistry (05.12.2014)
Published in The Journal of biological chemistry (05.12.2014)
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Journal Article
Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo
Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (07.01.2014)
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Journal Article
Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease
Kastanenka, Ksenia V, Hou, Steven S, Shakerdge, Naomi, Logan, Robert, Feng, Danielle, Wegmann, Susanne, Chopra, Vanita, Hawkes, Jonathan M, Chen, Xiqun, Bacskai, Brian J
Published in PloS one (23.01.2017)
Published in PloS one (23.01.2017)
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Journal Article
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro
Nobuhara, Chloe K., DeVos, Sarah L., Commins, Caitlin, Wegmann, Susanne, Moore, Benjamin D., Roe, Allyson D., Costantino, Isabel, Frosch, Matthew P., Pitstick, Rose, Carlson, George A., Hock, Christoph, Nitsch, Roger M., Montrasio, Fabio, Grimm, Jan, Cheung, Anne E., Dunah, Anthone W., Wittmann, Marion, Bussiere, Thierry, Weinreb, Paul H., Hyman, Bradley T., Takeda, Shuko
Published in The American journal of pathology (01.06.2017)
Published in The American journal of pathology (01.06.2017)
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Journal Article
Initiation and modulation of Tau protein phase separation by the drug suramin
Prince, Prabhu Rajaiah, Hochmair, Janine, Brognaro, Hévila, Gevorgyan, Susanna, Franck, Maximilian, Schubert, Robin, Lorenzen, Kristina, Yazici, Selin, Mandelkow, Eckhard, Wegmann, Susanne, Betzel, Christian
Published in Scientific reports (09.03.2023)
Published in Scientific reports (09.03.2023)
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Journal Article
Atypical, non-standard functions of the microtubule associated Tau protein
Sotiropoulos, Ioannis, Galas, Marie-Christine, Silva, Joana M, Skoulakis, Efthimios, Wegmann, Susanne, Maina, Mahmoud Bukar, Blum, David, Sayas, Carmen Laura, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Spillantini, Maria Grazia, Sousa, Nuno, Avila, Jesus, Medina, Miguel, Mudher, Amrit, Buee, Luc
Published in Acta neuropathologica communications (29.11.2017)
Published in Acta neuropathologica communications (29.11.2017)
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Journal Article
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
Takeda, Shuko, Commins, Caitlin, DeVos, Sarah L., Nobuhara, Chloe K., Wegmann, Susanne, Roe, Allyson D., Costantino, Isabel, Fan, Zhanyun, Nicholls, Samantha B., Sherman, Alexis E., Trisini Lipsanopoulos, Ana T., Scherzer, Clemens R., Carlson, George A., Pitstick, Rose, Peskind, Elaine R., Raskind, Murray A., Li, Ge, Montine, Thomas J., Frosch, Matthew P., Hyman, Bradley T.
Published in Annals of neurology (01.09.2016)
Published in Annals of neurology (01.09.2016)
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Journal Article
Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Published in The Journal of biological chemistry (18.07.2014)
Published in The Journal of biological chemistry (18.07.2014)
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Journal Article
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease
Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T
Published in Acta neuropathologica communications (24.03.2015)
Published in Acta neuropathologica communications (24.03.2015)
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Journal Article
Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98
Diez, Lisa, Kapinos, Larisa E, Hochmair, Janine, Huebschmann, Sabrina, Dominguez-Baquero, Alvaro, Vogt, Amelie, Rankovic, Marija, Zweckstetter, Markus, Lim, Roderick Y H, Wegmann, Susanne
Published in International journal of molecular sciences (23.03.2022)
Published in International journal of molecular sciences (23.03.2022)
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Journal Article
Tau protein liquid–liquid phase separation can initiate tau aggregation
Wegmann, Susanne, Eftekharzadeh, Bahareh, Tepper, Katharina, Zoltowska, Katarzyna M, Bennett, Rachel E, Dujardin, Simon, Laskowski, Pawel R, MacKenzie, Danny, Kamath, Tarun, Commins, Caitlin, Vanderburg, Charles, Roe, Allyson D, Fan, Zhanyun, Molliex, Amandine M, Hernandez‐Vega, Amayra, Muller, Daniel, Hyman, Anthony A, Mandelkow, Eckhard, Taylor, J Paul, Hyman, Bradley T
Published in The EMBO journal (03.04.2018)
Published in The EMBO journal (03.04.2018)
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