Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase
Ernst, Justin T., Thompson, Peggy A., Nilewski, Christian, Sprengeler, Paul A., Sperry, Samuel, Packard, Garrick, Michels, Theodore, Xiang, Alan, Tran, Chinh, Wegerski, Christopher J., Eam, Boreth, Young, Nathan P., Fish, Sarah, Chen, Joan, Howard, Haleigh, Staunton, Jocelyn, Molter, Jolene, Clarine, Jeff, Nevarez, Andres, Chiang, Gary G., Appleman, Jim R., Webster, Kevin R., Reich, Siegfried H.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Journal Article
Disposition and metabolism of 2′,2′”-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application
Garner, C. Edwin, Wegerski, Christopher J., Doyle-Eisele, Melanie, McDonald, Jacob D., Sanders, J. Michael, Moeller, Benjamin C., Waidyanatha, Suramya
Published in Toxicology reports (01.01.2020)
Published in Toxicology reports (01.01.2020)
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Journal Article
Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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Journal Article
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A
Thompson, Peggy A, Eam, Boreth, Young, Nathan P, Fish, Sarah, Chen, Joan, Barrera, Maria, Howard, Haleigh, Sung, Eric, Parra, Ana, Staunton, Jocelyn, Chiang, Gary G, Gerson-Gurwitz, Adina, Wegerski, Christopher J, Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Nilewski, Christian, Packard, Garrick K, Michels, Theodore, Tran, Chinh, Sprengeler, Paul A, Ernst, Justin T, Reich, Siegfried H, Webster, Kevin R
Published in Molecular cancer therapeutics (01.01.2021)
Published in Molecular cancer therapeutics (01.01.2021)
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Journal Article
Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors
Nilewski, Christian, Michels, Theodore D, Xiang, Alan X, Packard, Garrick K, Sprengeler, Paul A, Eam, Boreth, Fish, Sarah, Thompson, Peggy A, Wegerski, Christopher J, Ernst, Justin T, Reich, Siegfried H
Published in Organic letters (21.08.2020)
Published in Organic letters (21.08.2020)
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Journal Article
1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties
Nilewski, Christian, Michels, Theodore D., Packard, Garrick K., Xiang, Alan X., Sprengeler, Paul A., Eam, Boreth, Fish, Sarah, Thompson, Peggy A., Wegerski, Christopher J., Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Ernst, Justin T., Reich, Siegfried H.
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Journal Article
Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison
Mutlu, Esra, Garner, C. Edwin, Wegerski, Christopher J., McDonald, Jacob D., McIntyre, Barry S., Doyle-Eisele, Melanie, Waidyanatha, Suramya
Published in Xenobiotica (02.06.2020)
Published in Xenobiotica (02.06.2020)
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Journal Article
Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure
Waidyanatha, Suramya, Ryan, Kristen, Sanders, J. Michael, McDonald, Jacob D., Wegerski, Christopher J., Doyle-Eisle, Melanie, Garner, C. Edwin
Published in Toxicology and applied pharmacology (15.01.2018)
Published in Toxicology and applied pharmacology (15.01.2018)
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Journal Article
Abstract B33: Targeting PI3K/mTOR signaling with potent, selective and orally-available small-molecule inhibitors of eIF4E
Parker, Gregory S., Hung, Ivy N.J., Staunton, Jocelyn, Barrera, Maria, Sung, Eric, Parra, Ana, Stumpf, Craig R., Chen, Joan, Thompson, Peggy A., Nevarez, Andreas, Wegerski, Christopher J., Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Nilewski, Christian, Packard, Garrick K., Urklalan, Kaveri, Mukaiyama, Takasuke, Michels, Theo, Ernst, Justin T., Sprengeler, Paul A., Reich, Siegfried H., Chiang, Gary G., Webster, Kevin R.
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
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Journal Article
Abstract 2698: eFT226, a potent and selective inhibitor of eIF4A, is efficacious in preclinical models of lymphoma
Thompson, Peggy A., Eam, Boreth, Young, Nathan P., Fish, Sarah, Chen, Joan, Barrera, Maria, Howard, Haleigh, Sung, Eric, Parra, Ana, Staunton, Jocelyn, Chiang, Gary G., Wegerski, Christopher J., Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Tran, Chinh, Nilewski, Christian, Packard, Garrick K., Michels, Theodore, Sprengeler, Paul A., Ernst, Justin T., Reich, Siegfried H., Webster, Kevin R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 1302: Targeting hormone receptor-dependent cancers with potent, selective and orally-available small molecule inhibitors of eIF4E
Chiang, Gary G., Parker, Gregory S., Hung, Ivy N., Goel, Vikas K., Staunton, Jocelyn, Barrera, Maria, Sung, Eric, Parra, Ana, Stumpf, Craig R., Chen, Joan, Thompson, Peggy A., Nevarez, Andreas, Wegerski, Christopher J., Parker, Cody, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Nilewski, Christian, Packard, Garrick K., Urkalan, Kaveri, Mukaiyama, Takasuke, Michels, Theo, Ernst, Justin T., Sprengeler, Paul A., Reich, Siegfried H., Webster, Kevin R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract B133: eFT226, a first in class inhibitor of eIF4A1, targets FGFR1/2 and HER2 driven cancers
Thompson, Peggy A, Young, Nathan P, Stumpf, Craig R, Eam, Boreth, Goel, Vikas K, Chen, Joan, Fish, Sarah, Parker, Gregory S, Gerson-Gurwitz, Adina, Barrera, Maria, Sung, Eric, Staunton, Jocelyn, Chiang, Gary G, Wegerski, Christopher J, Sperry, Samuel, Webster, Kevin R, Reich, Siegfried H
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Abstract DDT02-05: eFT226: A selective and highly potent inhibitor of eukaryotic initiation factor 4A (eIF4A), a novel approach for the treatment of cancer
Reich, Siegfried H., Thompson, Peggy A., Ernst, Justin T., Eam, Boreth, Young, Nathan P., Fish, Sarah, Chen, Joan, Barrera, Maria, Howard, Haleigh, Parra, Ana, Sung, Eric, Staunton, Jocelyn, Hung, Ivy Nj, Parker, Gregory S., Chiang, Gary G., Wegerski, Christopher J., Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Xiang, Alan, Tran, Chinh, Nilewski, Christian, Packard, Garrick K., Michels, Theodore, Sprengeler, Paul A., Webster, Kevin R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 596: eFT508, a potent and highly selective inhibitor of MNK1/2 regulates immune checkpoint and cytokine expression promoting anti-tumor immunity
Webster, Kevin R., Goel, Vikas K., Staunton, Jocelyn, Stumpf, Craig R., Sharma, Rajesh, Hung, Ivy N., Parker, Gregory S., Molter, Jolene, Chiang, Gary G., Wegerski, Christopher J., Sperry, Samuel, Huang, Vera, Chen, Joan, Thompson, Peggy A., Tran, Chinh, Ernst, Justin T., Sprengeler, Paul A., Reich, Siegfried H.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract PR11: eFT508: An oral, potent and highly selective inhibitor of MNK1 and MNK2, promotes anti-tumor immunity as a monotherapy and in combination with immune checkpoint blockade
Webster, Kevin R., Goel, Vikas K., Staunton, Jocelyn, Hung, Ivy NJ, Parker, Gregory S., Stumpf, Craig R., Molter, Jolene, Chiang, Gary G., Wegerski, Christopher J., Sperry, Samuel, Chen, Joan, Huang, Vera, Thompson, Peggy A., Tran, Chinh, Ernst, Justin T., Webber, Stephen E., Sprengeler, Paul A., Reich, Siegfried H.
Published in Cancer research (Chicago, Ill.) (15.03.2017)
Published in Cancer research (Chicago, Ill.) (15.03.2017)
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Journal Article
eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL)
Webster, Kevin R., Goel, Vikas K, Hung, Ivy NJ, Parker, Gregory S, Staunton, Jocelyn, Neal, Melissa, Molter, Jolene, Chiang, Gary G, Jessen, Katti A., Wegerski, Christopher J, Sperry, Samuel, Huang, Vera, Chen, Joan, Thompson, Peggy A, Appleman, James R, Webber, Stephen E, Sprengeler, Paul A, Reich, Siegfried H
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article