The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
Wedekind, Lauren E., Mahajan, Anubha, Hsueh, Wen-Chi, Chen, Peng, Olaiya, Muideen T., Kobes, Sayuko, Sinha, Madhumita, Baier, Leslie J., Knowler, William C., McCarthy, Mark I., Hanson, Robert L.
Published in Diabetologia (01.05.2023)
Published in Diabetologia (01.05.2023)
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Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations
Srivastava, Yoshita, Akinyemi, Olayinka, Rohe, Tiana C, Pritchett, Elizabeth M, Baker, Cameron D, Sharma, Akshara, Jenkins, Jermaine L, Mathews, David H, Wedekind, Joseph E
Published in Nucleic acids research (16.10.2024)
Published in Nucleic acids research (16.10.2024)
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A riboswitch separated from its ribosome-binding site still regulates translation
Schroeder, Griffin M, Akinyemi, Olayinka, Malik, Jeffrey, Focht, Caroline M, Pritchett, Elizabeth M, Baker, Cameron D, McSally, James P, Jenkins, Jermaine L, Mathews, David H, Wedekind, Joseph E
Published in Nucleic acids research (21.03.2023)
Published in Nucleic acids research (21.03.2023)
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RNA target highlights in CASP15: Evaluation of predicted models by structure providers
Kretsch, Rachael C., Andersen, Ebbe S., Bujnicki, Janusz M., Chiu, Wah, Das, Rhiju, Luo, Bingnan, Masquida, Benoît, McRae, Ewan K. S., Schroeder, Griffin M., Su, Zhaoming, Wedekind, Joseph E., Xu, Lily, Zhang, Kaiming, Zheludev, Ivan N., Moult, John, Kryshtafovych, Andriy
Published in Proteins, structure, function, and bioinformatics (01.12.2023)
Published in Proteins, structure, function, and bioinformatics (01.12.2023)
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Journal Article
In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma
Veringa, Susanna J E, Biesmans, Dennis, van Vuurden, Dannis G, Jansen, Marc H A, Wedekind, Laurine E, Horsman, Ilona, Wesseling, Pieter, Vandertop, William Peter, Noske, David P, Kaspers, GertJan J L, Hulleman, Esther
Published in PloS one (29.04.2013)
Published in PloS one (29.04.2013)
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Structural analysis of a class III preQ₁ riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics
Liberman, Joseph A., Suddala, Krishna C., Aytenfisu, Asaminew, Chan, Dalen, Belashov, Ivan A., Salim, Mohammad, Mathews, David H., Spitale, Robert C., Walter, Nils G., Wedekind, Joseph E.
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2015)
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Radio-sensitizing effect of MEK inhibition in glioblastoma in vitro and in vivo
Houweling, M., Abdul, U. K., Brahm, C., Lagerweij, T., Heukelom, S., Koken, P. W., Honeywell, R., Wedekind, L. E., Peters, G. J., Verheul, H., Sminia, P., Noske, D., Wurdinger, T., Westerman, B. A.
Published in Journal of cancer research and clinical oncology (2023)
Published in Journal of cancer research and clinical oncology (2023)
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Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
Antunes-Ferreira, Mafalda, D’Ambrosi, Silvia, Arkani, Mohammad, Post, Edward, In ‘t Veld, Sjors G. J. G., Ramaker, Jip, Zwaan, Kenn, Kucukguzel, Ece Demirel, Wedekind, Laurine E., Griffioen, Arjan W., Oude Egbrink, Mirjam, Kuijpers, Marijke J. E., van den Broek, Daan, Noske, David P., Hartemink, Koen J., Sabrkhany, Siamack, Bahce, Idris, Sol, Nik, Bogaard, Harm-Jan, Koppers-Lalic, Danijela, Best, Myron G., Wurdinger, Thomas
Published in Scientific reports (08.06.2023)
Published in Scientific reports (08.06.2023)
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Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide
van Nifterik, K A, van den Berg, J, van der Meide, W F, Ameziane, N, Wedekind, L E, Steenbergen, R D M, Leenstra, S, Lafleur, M V M, Slotman, B J, Stalpers, L J A, Sminia, P
Published in British journal of cancer (29.06.2010)
Published in British journal of cancer (29.06.2010)
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Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma
Sol, Nik, in ‘t Veld, Sjors G.J.G., Vancura, Adrienne, Tjerkstra, Maud, Leurs, Cyra, Rustenburg, François, Schellen, Pepijn, Verschueren, Heleen, Post, Edward, Zwaan, Kenn, Ramaker, Jip, Wedekind, Laurine E., Tannous, Jihane, Ylstra, Bauke, Killestein, Joep, Mateen, Farrah, Idema, Sander, de Witt Hamer, Philip C., Navis, Anna C., Leenders, William P.J., Hoeben, Ann, Moraal, Bastiaan, Noske, David P., Vandertop, W. Peter, Nilsson, R. Jonas A., Tannous, Bakhos A., Wesseling, Pieter, Reijneveld, Jaap C., Best, Myron G., Wurdinger, Thomas
Published in Cell reports. Medicine (20.10.2020)
Published in Cell reports. Medicine (20.10.2020)
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A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme Catalysis
Liberman, Joseph A, Guo, Man, Jenkins, Jermaine L, Krucinska, Jolanta, Chen, Yuanyuan, Carey, Paul R, Wedekind, Joseph E
Published in Journal of the American Chemical Society (17.10.2012)
Published in Journal of the American Chemical Society (17.10.2012)
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Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing
Srivastava, Yoshita, Bonn-Breach, Rachel, Chavali, Sai Shashank, Lippa, Geoffrey M, Jenkins, Jermaine L, Wedekind, Joseph E
Published in Crystals (Basel) (01.03.2021)
Published in Crystals (Basel) (01.03.2021)
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Journal Article
APOBEC3G Subunits Self-associate via the C-terminal Deaminase Domain
Bennett, Ryan P., Salter, Jason D., Liu, Xiang, Wedekind, Joseph E., Smith, Harold C.
Published in The Journal of biological chemistry (28.11.2008)
Published in The Journal of biological chemistry (28.11.2008)
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Journal Article
Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits
Wedekind, Joseph E., Gillilan, Richard, Janda, Alena, Krucinska, Jolanta, Salter, Jason D., Bennett, Ryan P., Raina, Jay, Smith, Harold C.
Published in The Journal of biological chemistry (15.12.2006)
Published in The Journal of biological chemistry (15.12.2006)
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Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation
Guo, Man, Spitale, Robert C, Volpini, Rosaria, Krucinska, Jolanta, Cristalli, Gloria, Carey, Paul R, Wedekind, Joseph E
Published in Journal of the American Chemical Society (16.09.2009)
Published in Journal of the American Chemical Society (16.09.2009)
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Journal Article
Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic Retention Signal and Is Not Dependent on RNA Binding
Bennett, Ryan P., Presnyak, Vladimir, Wedekind, Joseph E., Smith, Harold C.
Published in The Journal of biological chemistry (21.03.2008)
Published in The Journal of biological chemistry (21.03.2008)
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