Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers
Wedagedera, Janak R., Afuape, Anthonia, Chirumamilla, Siri Kalyan, Momiji, Hiroshi, Leary, Robert, Dunlavey, Mike, Matthews, Richard, Abduljalil, Khaled, Jamei, Masoud, Bois, Frederic Y.
Published in CPT: pharmacometrics and systems pharmacology (01.06.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2022)
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Journal Article
P214 - Investigating the impact of enzyme correlations on inter-individual variability in pharmacokinetics and drug-drug interactions
Hatley, Oliver, Ezuruike, Udoamaka, Wedagedera, Janak, Takahashi, Ryan, Mao, Jialin, Gardner, Iain
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
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Journal Article
Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz
Chetty, Manoranjenni, Cain, Theresa, Wedagedera, Janak, Rostami-Hodjegan, Amin, Jamei, Masoud
Published in Frontiers in pharmacology (27.03.2018)
Published in Frontiers in pharmacology (27.03.2018)
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Journal Article
Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses
Zhang, Zufei, Imperial, Marjorie Z, Patilea-Vrana, Gabriela I, Wedagedera, Janak, Gaohua, Lu, Unadkat, Jashvant D
Published in Drug metabolism and disposition (01.08.2017)
Published in Drug metabolism and disposition (01.08.2017)
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Journal Article