Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues
Cobice, Diego F, Mackay, C. Logan, Goodwin, Richard J. A, McBride, Andrew, Langridge-Smith, Patrick R, Webster, Scott P, Walker, Brian R, Andrew, Ruth
Published in Analytical chemistry (Washington) (03.12.2013)
Published in Analytical chemistry (Washington) (03.12.2013)
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Journal Article
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury
Zheng, Xiaozhong, Zhang, Ailiang, Binnie, Margaret, McGuire, Kris, Webster, Scott P, Hughes, Jeremy, Howie, Sarah E M, Mole, Damian J
Published in Experimental & molecular medicine (13.02.2019)
Published in Experimental & molecular medicine (13.02.2019)
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Journal Article
11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis
Davidson, Callam T, Miller, Eileen, Muir, Morwenna, Dawson, John C, Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P, Homer, Natalie Z M, Andrew, Ruth, Brunton, Valerie G, Hadoke, Patrick W F, Walker, Brian R
Published in PloS one (01.03.2023)
Published in PloS one (01.03.2023)
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Journal Article
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
McNae, Iain W, Kinkead, James, Malik, Divya, Yen, Li-Hsuan, Walker, Martin K, Swain, Chris, Webster, Scott P, Gray, Nick, Fernandes, Peter M, Myburgh, Elmarie, Blackburn, Elizabeth A, Ritchie, Ryan, Austin, Carol, Wear, Martin A, Highton, Adrian J, Keats, Andrew J, Vong, Antonio, Dornan, Jacqueline, Mottram, Jeremy C, Michels, Paul A M, Pettit, Simon, Walkinshaw, Malcolm D
Published in Nature communications (16.02.2021)
Published in Nature communications (16.02.2021)
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Journal Article
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
Hutchinson, Jonathan P, Rowland, Paul, Taylor, Mark R D, Christodoulou, Erica M, Haslam, Carl, Hobbs, Clare I, Holmes, Duncan S, Homes, Paul, Liddle, John, Mole, Damian J, Uings, Iain, Walker, Ann L, Webster, Scott P, Mowat, Christopher G, Chung, Chun-Wa
Published in Nature communications (12.06.2017)
Published in Nature communications (12.06.2017)
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Journal Article
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis
Hayes, Alastair J., Zheng, Xiaozhong, O’Kelly, James, Neyton, Lucile P.A., Bochkina, Natalia A., Uings, Iain, Liddle, John, Baillie, J. Kenneth, Just, George, Binnie, Margaret, Homer, Natalie Z.M., Murray, Toby B.J., Baily, James, McGuire, Kris, Skouras, Christos, Garden, O. James, Webster, Scott P., Iredale, John P., Howie, Sarah E.M., Mole, Damian J.
Published in Cell reports (Cambridge) (29.08.2023)
Published in Cell reports (Cambridge) (29.08.2023)
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Journal Article
11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice
Coutinho, Agnes E, Kipari, Tiina M. J, Zhang, Zhenguang, Esteves, Cristina L, Lucas, Christopher D, Gilmour, James S, Webster, Scott P, Walker, Brian R, Hughes, Jeremy, Savill, John S, Seckl, Jonathan R, Rossi, Adriano G, Chapman, Karen E
Published in Endocrinology (Philadelphia) (01.07.2016)
Published in Endocrinology (Philadelphia) (01.07.2016)
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Journal Article
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
Skouras, Christos, Zheng, Xiaozhong, Binnie, Margaret, Homer, Natalie Z M, Murray, Toby B J, Robertson, Darren, Briody, Lesley, Paterson, Finny, Spence, Heather, Derr, Lisa, Hayes, Alastair J, Tsoumanis, Andreas, Lyster, Dawn, Parks, Rowan W, Garden, O James, Iredale, John P, Uings, Iain J, Liddle, John, Wright, Wayne L, Dukes, George, Webster, Scott P, Mole, Damian J
Published in Scientific reports (27.09.2016)
Published in Scientific reports (27.09.2016)
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Journal Article
UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1
Shave, Steven, Blackburn, Elizabeth A, Adie, Jillian, Houston, Douglas R, Auer, Manfred, Webster, Scott P, Taylor, Paul, Walkinshaw, Malcolm D
Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Journal Article
Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia
Chapagain, Ananda, Caton, Paul W., Kieswich, Julius, Andrikopoulos, Petros, Nayuni, Nanda, Long, Jamie H., Harwood, Steven M., Webster, Scott P., Raftery, Martin J., Thiemermann, Christoph, Walker, Brian R., Seckl, Jonathan R., Corder, Roger, Yaqoob, Muhammad Magdi
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
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Journal Article
Diclofenac Identified as a Kynurenine 3‑Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques
Shave, Steven, McGuire, Kris, Pham, Nhan T, Mole, Damian J, Webster, Scott P, Auer, Manfred
Published in ACS omega (31.03.2018)
Published in ACS omega (31.03.2018)
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Journal Article
β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction
Liu, Xiaoxia, Turban, Sophie, Carter, Roderick N, Ahmad, Shakil, Ramage, Lynne, Webster, Scott P, Walker, Brian R, Seckl, Jonathan R, Morton, Nicholas M
Published in Frontiers in endocrinology (Lausanne) (01.01.2014)
Published in Frontiers in endocrinology (Lausanne) (01.01.2014)
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Journal Article
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet, Lionel, Bénéton, Véronique, Mowat, Christopher G, Wilkinson, Martin, Rowland, Paul, Haslam, Carl, McBride, Andrew, Homer, Natalie Z M, Baily, James E, Sharp, Matthew G F, Garden, O James, Hughes, Jeremy, Howie, Sarah E M, Holmes, Duncan S, Liddle, John, Iredale, John P
Published in Nature medicine (01.02.2016)
Published in Nature medicine (01.02.2016)
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Journal Article
Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease
Sooy, Karen, Noble, June, McBride, Andrew, Binnie, Margaret, Yau, Joyce L. W, Seckl, Jonathan R, Walker, Brian R, Webster, Scott P
Published in Endocrinology (Philadelphia) (01.12.2015)
Published in Endocrinology (Philadelphia) (01.12.2015)
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Journal Article
Mechanism of 8-Amino-7-oxononanoate Synthase: Spectroscopic, Kinetic, and Crystallographic Studies
Webster, Scott P, Alexeev, Dmitriy, Campopiano, Dominic J, Watt, Rory M, Alexeeva, Marina, Sawyer, Lindsay, Baxter, Robert L
Published in Biochemistry (Easton) (25.01.2000)
Published in Biochemistry (Easton) (25.01.2000)
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Journal Article
Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Brossaud, Julie, Bosch-Bouju, Clémentine, Marissal-Arvy, Nathalie, Campas-Lebecque, Marie-Neige, Helbling, Jean-Christophe, Webster, Scott P., Walker, Brian R., Fioramonti, Xavier, Ferreira, Guillaume, Barat, Pascal, Corcuff, Jean-Benoît, Moisan, Marie-Pierre
Published in Diabetologia (01.09.2023)
Published in Diabetologia (01.09.2023)
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Journal Article
Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase
Fraser, Craig, Dawson, John C, Dowling, Reece, Houston, Douglas R, Weiss, Jason T, Munro, Alison F, Muir, Morwenna, Harrington, Lea, Webster, Scott P, Frame, Margaret C, Brunton, Valerie G, Patton, E. Elizabeth, Carragher, Neil O, Unciti-Broceta, Asier
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
Webster, Scott P, McBride, Andrew, Binnie, Margaret, Sooy, Karen, Seckl, Jonathan R, Andrew, Ruth, Pallin, T David, Hunt, Hazel J, Perrior, Trevor R, Ruffles, Vincent S, Ketelbey, J William, Boyd, Alan, Walker, Brian R
Published in British journal of pharmacology (01.03.2017)
Published in British journal of pharmacology (01.03.2017)
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