APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
Xiong, Monica, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R, Wang, Chao, Gratuze, Maud, Hoyle, Rosa, Bien-Ly, Nga, Silverman, Adam P, Sullivan, Patrick M, Watts, Ryan J, Ulrich, Jason D, Zipfel, Gregory J, Holtzman, David M
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Published in Science translational medicine (17.02.2021)
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Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
Bien-Ly, Nga, Boswell, C. Andrew, Jeet, Surinder, Beach, Thomas G., Hoyte, Kwame, Luk, Wilman, Shihadeh, Vera, Ulufatu, Sheila, Foreman, Oded, Lu, Yanmei, DeVoss, Jason, van der Brug, Marcel, Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (21.10.2015)
Published in Neuron (Cambridge, Mass.) (21.10.2015)
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Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop, Dara, Weimer, Robby M., Lu, Yanmei, Kirkpatrick, Donald S., Ernst, James A., Chih, Ben, Dennis, Mark S., Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (06.01.2016)
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Engaging neuroscience to advance translational research in brain barrier biology
Neuwelt, Edward A, Bauer, Björn, Fahlke, Christoph, Fricker, Gert, Iadecola, Constantino, Janigro, Damir, Leybaert, Luc, Molnár, Zoltán, O'Donnell, Martha E, Povlishock, John T, Saunders, Norman R, Sharp, Frank, Stanimirovic, Danica, Watts, Ryan J, Drewes, Lester R
Published in Nature reviews. Neuroscience (01.03.2011)
Published in Nature reviews. Neuroscience (01.03.2011)
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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Yu, Y Joy, Zhang, Yin, Kenrick, Margaret, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Atwal, Jasvinder, Elliott, J Michael, Prabhu, Saileta, Watts, Ryan J, Dennis, Mark S
Published in Science translational medicine (25.05.2011)
Published in Science translational medicine (25.05.2011)
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert
Published in Neuron (Cambridge, Mass.) (04.03.2020)
Published in Neuron (Cambridge, Mass.) (04.03.2020)
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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J
Published in The Journal of experimental medicine (10.02.2014)
Published in The Journal of experimental medicine (10.02.2014)
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A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
JONSSON, Thorlakur, ATWAL, Jasvinder K, HOYTE, Kwame, GUSTAFSON, Amy, LIU, Yichin, YANMEI LU, BHANGALE, Tushar, GRAHAM, Robert R, HUTTENLOCHER, Johanna, BJORNSDOTTIR, Gyda, ANDREASSEN, Ole A, JÖNSSON, Erik G, STEINBERG, Stacy, PALOTIE, Aarno, BEHRENS, Timothy W, MAGNUSSON, Olafur T, KONG, Augustine, THORSTEINSDOTTIR, Unnur, WATTS, Ryan J, STEFANSSON, Kari, SNAEDAL, Jon, JONSSON, Palmi V, BJORNSSON, Sigurbjorn, STEFANSSON, Hreinn, SULEM, Patrick, GUDBJARTSSON, Daniel, MALONEY, Janice
Published in Nature (London) (02.08.2012)
Published in Nature (London) (02.08.2012)
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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein
Maloney, Janice A., Bainbridge, Travis, Gustafson, Amy, Zhang, Shuo, Kyauk, Roxanne, Steiner, Pascal, van der Brug, Marcel, Liu, Yichin, Ernst, James A., Watts, Ryan J., Atwal, Jasvinder K.
Published in The Journal of biological chemistry (07.11.2014)
Published in The Journal of biological chemistry (07.11.2014)
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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.
Published in The Journal of biological chemistry (03.03.2017)
Published in The Journal of biological chemistry (03.03.2017)
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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Yu, Y Joy, Atwal, Jasvinder K, Zhang, Yin, Tong, Raymond K, Wildsmith, Kristin R, Tan, Christine, Bien-Ly, Nga, Hersom, Maria, Maloney, Janice A, Meilandt, William J, Bumbaca, Daniela, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Ernst, James A, Scearce-Levie, Kimberly, Couch, Jessica A, Dennis, Mark S, Watts, Ryan J
Published in Science translational medicine (05.11.2014)
Published in Science translational medicine (05.11.2014)
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Neuropilins in Tumor Biology
BAGRI, Anil, TESSIER-LAVIGNE, Marc, WATTS, Ryan J
Published in Clinical cancer research (15.03.2009)
Published in Clinical cancer research (15.03.2009)
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Therapeutic antibody targeting of individual Notch receptors
Zha, Jiping, Dow, Graham J, Chen, Yongmei, Watts, Ryan J, Callahan, Christopher A, Finkle, David, Wu, Yan, Hagenbeek, Thijs J, Venook, Rayna, de Leon, Gladys P, Siebel, Christian W, Choy, Lisa, Cain-Hom, Carol, Choy, Robert, Schahin-Reed, Dorreyah, Ridgway, John, Yan, Minhong, Stawicki, Scott, Hymowitz, Sarah G, Wu, Xiumin, Shelton, Amy, Kadyk, Lisa, Howard, Peter, Zhang, Jeff
Published in Nature (London) (15.04.2010)
Published in Nature (London) (15.04.2010)
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Adolfsson, Oskar, Pihlgren, Maria, Toni, Nicolas, Varisco, Yvan, Buccarello, Anna Lucia, Antoniello, Katia, Lohmann, Sophie, Piorkowska, Kasia, Gafner, Valerie, Atwal, Jasvinder K, Maloney, Janice, Chen, Mark, Gogineni, Alvin, Weimer, Robby M, Mortensen, Deborah L, Friesenhahn, Michel, Ho, Carole, Paul, Robert, Pfeifer, Andrea, Muhs, Andreas, Watts, Ryan J
Published in The Journal of neuroscience (11.07.2012)
Published in The Journal of neuroscience (11.07.2012)
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert
Published in Cell (02.09.2021)
Published in Cell (02.09.2021)
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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models
van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I, Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E, Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M, Beumers, Philipp, Capell, Anja, Davis, Sonnet S, de Weerd, Lis, Dugas, Jason C, Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T, Kunze, Lea H, Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O, Nguyen, Hoang N, Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H, Thorne, Robert G, Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y Joy Yu, Diaz, Dolo, Dennis, Mark S, Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J, Haass, Christian, Lewcock, Joseph W, Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E, Monroe, Kathryn M
Published in Nature neuroscience (01.03.2023)
Published in Nature neuroscience (01.03.2023)
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