Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice
Yu, Xing Xian, Watts, Lynnetta M, Manchem, Vara Prasad, Chakravarty, Kaushik, Monia, Brett P, McCaleb, Michael L, Bhanot, Sanjay
Published in PloS one (29.07.2013)
Published in PloS one (29.07.2013)
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Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
Digenio, Andres, Pham, Nguyen C., Watts, Lynnetta M., Morgan, Erin S., Jung, Shiangtung W., Baker, Brenda F., Geary, Richard S., Bhanot, Sanjay
Published in Diabetes care (01.04.2018)
Published in Diabetes care (01.04.2018)
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Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy
Morgan, Erin S., Tai, Li-Jung, Pham, Nguyen C., Overman, Julia K., Watts, Lynnetta M., Smith, Anne, Jung, Shiangtung W., Gajdošík, Martin, Krššák, Martin, Krebs, Michael, Geary, Richard S., Baker, Brenda F., Bhanot, Sanjay
Published in Diabetes care (01.04.2019)
Published in Diabetes care (01.04.2019)
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Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys
Swarbrick, Michael M, Havel, Peter J, Levin, Arthur A, Bremer, Andrew A, Stanhope, Kimber L, Butler, Madeline, Booten, Sheri L, Graham, James L, McKay, Robert A, Murray, Susan F, Watts, Lynnetta M, Monia, Brett P, Bhanot, Sanjay
Published in Endocrinology (Philadelphia) (01.04.2009)
Published in Endocrinology (Philadelphia) (01.04.2009)
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Journal Article
Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice
Pandey, Sanjay K., Yu, Xing Xian, Watts, Lynnetta M., Michael, M. Dodson, Sloop, Kyle W., Rivard, Amber R., Leedom, Thomas A., Manchem, Vara Prasad, Samadzadeh, Laura, McKay, Robert A., Monia, Brett P., Bhanot, Sanjay
Published in The Journal of biological chemistry (11.05.2007)
Published in The Journal of biological chemistry (11.05.2007)
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Journal Article
Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
WATTS, Lynnetta M, VARA PRASAD MANCHEM, HONG YAN ZHANG, COX, Amy L, JACOBS, Steven J, MICHAEL, M. Dodson, SLOOP, Kyle W, BHANOT, Sanjay, LEEDOM, Thomas A, RIVARD, Amber L, MCKAY, Robert A, DINGJIU BAO, NEROLADAKIS, Teri, MONIA, Brett P, BODENMILLER, Diane M, CAO, Julia Xiao-Chun
Published in Diabetes (New York, N.Y.) (01.06.2005)
Published in Diabetes (New York, N.Y.) (01.06.2005)
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Journal Article
Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
Sloop, Kyle W, Cao, Julia Xiao-Chun, Siesky, Angela M, Zhang, Hong Yan, Bodenmiller, Diane M, Cox, Amy L, Jacobs, Steven J, Moyers, Julie S, Owens, Rebecca A, Showalter, Aaron D, Brenner, Martin B, Raap, Achim, Gromada, Jesper, Berridge, Brian R, Monteith, David K B, Porksen, Niels, McKay, Robert A, Monia, Brett P, Bhanot, Sanjay, Watts, Lynnetta M, Michael, M Dodson
Published in The Journal of clinical investigation (01.06.2004)
Published in The Journal of clinical investigation (01.06.2004)
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Journal Article
Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice
Liang, Yin, Osborne, Melville C., Monia, Brett P., Bhanot, Sanjay, Watts, Lynnetta M., She, Pengxiang, DeCarlo, Stephanie O., Chen, Xiaoli, Demarest, Keith
Published in Metabolism, clinical and experimental (01.07.2005)
Published in Metabolism, clinical and experimental (01.07.2005)
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Journal Article
Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
Sloop, Kyle W., Cao, Julia Xiao-Chun, Siesky, Angela M., Zhang, Hong Yan, Bodenmiller, Diane M., Cox, Amy L., Jacobs, Steven J., Moyers, Julie S., Owens, Rebecca A., Showalter, Aaron D., Brenner, Martin B., Raap, Achim, Gromada, Jesper, Berridge, Brian R., Monteith, David K. B., Porksen, Niels, McKay, Robert A., Monia, Brett P., Bhanot, Sanjay, Watts, Lynnetta M., Michael, M. Dodson
Published in The Journal of clinical investigation (01.06.2004)
Published in The Journal of clinical investigation (01.06.2004)
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Journal Article
PS-106-An international, randomized, placebo-controlled phase 2 trial demonstrates novel effects of DGAT2 antisense inhibition in reducing steatosis without causing hypertriglyceridemia in T2DM patients
Loomba, Rohit, Morgan, Erin, Fung, Maple, Watts, Lynnetta, Geary, Richard, Bhanot, Sanjay
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study
Oral, Elif A., Garg, Abhimanyu, Tami, Joseph, Huang, Eric A., O'Dea, Louis St.L., Schmidt, Hartmut, Tiulpakov, Anatoly, Mertens, Ann, Alexander, Veronica J., Watts, Lynnetta, Hurh, Eunju, Witztum, Joseph L., Geary, Richard S., Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.11.2022)
Published in Journal of clinical lipidology (01.11.2022)
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Journal Article
Corrigendum to “Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial” [Journal of Clinical Lipidology, Volume 17, Issue 3, May–June 2023, Pages 342–355]
Witztum, Joseph L., Gaudet, Daniel, Arca, Marcello, Jones, Alan, Soran, Handrean, Gouni-Berthold, Ioanna, Stroes, Erik S.G., Alexander, Veronica J., Jones, Richard, Watts, Lynnetta, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.05.2024)
Published in Journal of clinical lipidology (01.05.2024)
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Journal Article
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, Christine, Davis, Scott, Murray, Susan F., Yu, Xing Xian, Pandey, Sanjay K., Pear, Michael, Watts, Lynnetta, Booten, Sheri L., Graham, Mark, McKay, Robert, Subramaniam, Amuthakannan, Propp, Stephanie, Lollo, Bridget A., Freier, Susan, Bennett, C. Frank, Bhanot, Sanjay, Monia, Brett P.
Published in Cell metabolism (01.02.2006)
Published in Cell metabolism (01.02.2006)
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Corrigendum to "Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial" Journal of Clinical Lipidology, Volume 17, Issue 3, May-June 2023, Pages 342-355
Witztum, Joseph L, Gaudet, Daniel, Arca, Marcello, Jones, Alan, Soran, Handrean, Gouni-Berthold, Ioanna, Stroes, Erik S G, Alexander, Veronica J, Jones, Richard, Watts, Lynnetta, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.05.2024)
Published in Journal of clinical lipidology (01.05.2024)
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Journal Article
Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial
Witztum, Joseph L., Gaudet, Daniel, Arca, Marcello, Jones, Alan, Soran, Handrean, Gouni-Berthold, Ioanna, Stroes, Erik S.G., Alexander, Veronica J., Jones, Richard, Watts, Lynnetta, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.05.2023)
Published in Journal of clinical lipidology (01.05.2023)
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Journal Article
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study: Volanesorsen in FPLD; The BROADEN Study
Oral, Elif A, Garg, Abhimanyu, Tami, Joseph, Huang, Eric A, O'Dea, Louis St L, Schmidt, Hartmut, Tiulpakov, Anatoly, Mertens, Ann, Alexander, Veronica J, Watts, Lynnetta, Hurh, Eunju, Witztum, Joseph L, Geary, Richard S, Tsimikas, Sotirios
Published in Journal of clinical lipidology (01.11.2022)
Published in Journal of clinical lipidology (01.11.2022)
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Journal Article
Corrigendum to "Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial" [Journal of Clinical Lipidology, Volume 17, Issue 3, May-June 2023, Pages 342-355]
Witztum, Joseph L, Gaudet, Daniel, Arca, Marcello, Jones, Alan, Soran, Handrean, Gouni-Berthold, Ioanna, Stroes, Erik S G, Alexander, Veronica J, Jones, Richard, Watts, Lynnetta, Xia, Shuting, Tsimikas, Sotirios
Published in Journal of clinical lipidology (13.10.2023)
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Published in Journal of clinical lipidology (13.10.2023)
Journal Article
Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1B^sub Rx^ Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
Digenio, Andres, Pham, Nguyen C, Watts, Lynnetta M, Morgan, Erin S, Jung, Shiangtung W, Baker, Brenda F, Geary, Richard S, Bhanot, Sanjay
Published in Diabetes care (01.04.2018)
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Published in Diabetes care (01.04.2018)
Journal Article
Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model
Luu, Kenneth T., Morgan, Erin S., Bhanot, Sanjay, Geary, Richard, Smith, Anne, Bethune, Claudette, Watts, Lynnetta, Henry, Scott, Wang, Yanfeng
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2017)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2017)
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