UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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Journal Article
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside
Gibhard, Liezl, Coertzen, Dina, Reader, Janette, van der Watt, Mariëtte E, Birkholtz, Lyn-Marie, Wong, Ho Ning, Batty, Kevin T, Haynes, Richard K, Wiesner, Lubbe
Published in Pharmaceutics (03.12.2021)
Published in Pharmaceutics (03.12.2021)
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Journal Article
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products
Moyo, Phanankosi, Shamburger, William, van der Watt, Mariëtte E., Reader, Janette, de Sousa, Ana Carolina C., Egan, Timothy J., Maharaj, Vinesh J., Bringmann, Gerhard, Birkholtz, Lyn-Marie
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2020)
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Journal Article
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
Beteck, Richard M., Seldon, Ronnett, Coertzen, Dina, van der Watt, Mariëtte E., Reader, Janette, Mackenzie, Jared S., Lamprecht, Dirk A., Abraham, Matthew, Eribez, Korina, Müller, Joachim, Rui, Feng, Zhu, Guang, de Grano, Ruel Valerio, Williams, Ian D., Smit, Frans J., Steyn, Adrie J. C., Winzeler, Elizabeth A., Hemphill, Andrew, Birkholtz, Lyn-Marie, Warner, Digby F., N’Da, David D., Haynes, Richard K.
Published in Communications chemistry (02.10.2018)
Published in Communications chemistry (02.10.2018)
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Journal Article
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites
Mianda, Sephora Mutombo, Invernizzi, Luke, van der Watt, Mariëtte E., Reader, Janette, Moyo, Phanankosi, Birkholtz, Lyn-Marié, Maharaj, Vinesh J.
Published in Journal of ethnopharmacology (28.10.2022)
Published in Journal of ethnopharmacology (28.10.2022)
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Journal Article
New Transmission‐Selective Antimalarial Agents through Hit‐to‐Lead Optimization of 2‐([1,1′‐Biphenyl]‐4‐carboxamido)benzoic Acid Derivatives
Reader, Janette, Opperman, Daniel F. L., Watt, Mariëtte E., Theron, Anjo, Leshabane, Meta, Rocha, Shanté, Turner, Jonathan, Garrabrant, Kathleen, Piña, Ivett, Mills, Catherine, Woster, Patrick M., Birkholtz, Lyn‐Marié
Published in Chembiochem : a European journal of chemical biology (04.11.2022)
Published in Chembiochem : a European journal of chemical biology (04.11.2022)
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Journal Article
The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum
Watson, Savannah J., van der Watt, Mariëtte E., Theron, Anjo, Reader, Janette, Tshabalala, Sizwe, Erlank, Erica, Koekemoer, Lizette L., Naude, Mariska, Stampolaki, Marianna, Adewole, Feyisola, Sadowska, Katie, Pérez-Lozano, Pilar, Turcu, Andreea L., Vázquez, Santiago, Ko, Jihee, Mazurek, Ben, Singh, Davinder, Malwal, Satish R., Njoroge, Mathew, Chibale, Kelly, Onajole, Oluseye K., Kolocouris, Antonios, Oldfield, Eric, Birkholtz, Lyn-Marié
Published in ACS infectious diseases (13.09.2024)
Published in ACS infectious diseases (13.09.2024)
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Journal Article
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials
van der Watt, Mariëtte E, Reader, Janette, Churchyard, Alisje, Nondaba, Sindisiwe H, Lauterbach, Sonja B, Niemand, Jandeli, Abayomi, Sijuade, van Biljon, Riëtte A, Connacher, Jessica I, van Wyk, Roelof D J, Le Manach, Claire, Paquet, Tanya, González Cabrera, Diego, Brunschwig, Christel, Theron, Anjo, Lozano-Arias, Sonia, Rodrigues, Janneth F I, Herreros, Esperanza, Leroy, Didier, Duffy, James, Street, Leslie J, Chibale, Kelly, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie
Published in Journal of antimicrobial chemotherapy (01.05.2018)
Published in Journal of antimicrobial chemotherapy (01.05.2018)
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Journal Article
Activities of 11‐Azaartemisinin and N‐Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites
Harmse, Rozanne, Coertzen, Dina, Wong, Ho Ning, Smit, Frans J., van der Watt, Mariette E., Reader, Janette, Nondaba, Sindiswe H., Birkholtz, Lyn‐Marie, Haynes, Richard K., N'Da, David D.
Published in ChemMedChem (19.12.2017)
Published in ChemMedChem (19.12.2017)
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Journal Article
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
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Journal Article
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites
Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E., Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A., Kyle, Dennis E., Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K.
Published in Frontiers in chemistry (10.01.2020)
Published in Frontiers in chemistry (10.01.2020)
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Journal Article
Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines
Coertzen, Dina, Reader, Janette, van der Watt, Mariëtte E., Leshabane, Meta M., Langeveld, Henrico, Cheuka, Peter M., Dziwornu, Godwin A., Chibale, Kelly, Birkholtz, Lyn-Marie
Published in Transactions of the Royal Society of South Africa (02.09.2021)
Published in Transactions of the Royal Society of South Africa (02.09.2021)
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Journal Article
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage P. falciparum Including Pf KI3 C580Y Mutants and Liver Stage P. berghei Parasites
Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E, Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A, Kyle, Dennis E, Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K
Published in Frontiers in chemistry (2019)
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Published in Frontiers in chemistry (2019)
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