Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
Holler, Christopher J, Taylor, Georgia, McEachin, Zachary T, Deng, Qiudong, Watkins, William J, Hudson, Kathryn, Easley, Charles A, Hu, William T, Hales, Chadwick M, Rossoll, Wilfried, Bassell, Gary J, Kukar, Thomas
Published in Molecular neurodegeneration (24.06.2016)
Published in Molecular neurodegeneration (24.06.2016)
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Waltzing transporters and 'the dance macabre' between humans and bacteria
Lomovskaya, Olga, Zgurskaya, Helen I, Totrov, Maxim, Watkins, William J
Published in Nature reviews. Drug discovery (01.01.2007)
Published in Nature reviews. Drug discovery (01.01.2007)
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Exercise-Induced Bronchoconstriction in School-Aged Children Who Had Chronic Lung Disease in Infancy
Joshi, Suchita, PhD, MRCPaed, Powell, Thomas, PhD, Watkins, William J., PhD, Drayton, Mark, MD, FRCPCH, Williams, E. Mark, PhD, Kotecha, Sailesh, PhD, FRCPCH
Published in The Journal of pediatrics (01.04.2013)
Published in The Journal of pediatrics (01.04.2013)
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The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model
Schwabl, Philipp, Hambruch, Eva, Budas, Grant R, Supper, Paul, Burnet, Michael, Liles, John T, Birkel, Manfred, Brusilovskaya, Ksenia, Königshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J, Trauner, Michael, Breckenridge, David G, Kremoser, Claus, Reiberger, Thomas
Published in Biomedicines (09.01.2021)
Published in Biomedicines (09.01.2021)
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miR-141 mediates recovery from acute kidney injury
Newbury, Lucy J., Simpson, Kate, Khalid, Usman, John, Imogen, de Rivera, Lluís Bailach, Lu, Yueh-An, Lopez-Anton, Melisa, Watkins, William J., Jenkins, Robert H., Fraser, Donald J., Bowen, Timothy
Published in Scientific reports (13.08.2021)
Published in Scientific reports (13.08.2021)
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Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Farand, Julie, Mai, Nicholas, Chandrasekhar, Jayaraman, Newby, Zachary E., Van Veldhuizen, Josh, Loyer-Drew, Jennifer, Venkataramani, Chandrasekar, Guerrero, Juan, Kwok, Amy, Li, Ning, Zherebina, Yelena, Wilbert, Sibylle, Zablocki, Jeff, Phillips, Gary, Watkins, William J., Mourey, Robert, Notte, Gregory T.
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors
LANSDON, Eric B, QI LIU, KIRSCHBERG, Thorsten A, LEAVITT, Stephanie A, BALAKRISHNAN, Mini, PERRY, Jason K, LANCASTER-MOYER, Candra, KUTTY, Nilima, XIAOHONG LIU, SQUIRES, Neil H, WATKINS, William J
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
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RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information
Kirschberg, Thorsten A, Balakrishnan, Mini, Squires, Neil H, Barnes, Tiffany, Brendza, Katherine M, Chen, Xiaowu, Eisenberg, Eugene J, Jin, Weili, Kutty, Nilima, Leavitt, Stephanie, Liclican, Albert, Liu, Qi, Liu, Xiaohong, Mak, John, Perry, Jason K, Wang, Michael, Watkins, William J, Lansdon, Eric B
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors
Boyce, Sarah E, Tirunagari, Neeraj, Niedziela-Majka, Anita, Perry, Jason, Wong, Melanie, Kan, Elaine, Lagpacan, Leanna, Barauskas, Ona, Hung, Magdeleine, Fenaux, Martijn, Appleby, Todd, Watkins, William J, Schmitz, Uli, Sakowicz, Roman
Published in PloS one (2014)
Published in PloS one (2014)
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
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GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma
Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B
Published in Clinical cancer research (01.05.2008)
Published in Clinical cancer research (01.05.2008)
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Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma
VAIL, David M, THAMM, Douglas H, JERAJ, Robert, VANDERHOEK, Matt, PLAZA, Susan, ANDERSON, Christie, WESSEL, Mackenzie A, REBATE, Cecilia, LAWRENCE, Jessica, TUMAS, Daniel B, REISER, Hans, RAY, Adrian S, WOLFGANG, Grushenka H. I, WATKINS, William J, BABUSIS, Darius, HENNE, Ilana N, HAWKINS, Michael J, KURZMAN, Ilene D
Published in Clinical cancer research (15.05.2009)
Published in Clinical cancer research (15.05.2009)
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Development of Cilofexor, an Intestinally-Biased Farnesoid X Receptor Agonist, for the Treatment of Fatty Liver Disease
Hollenback, David, Hambruch, Eva, Fink, Gero, Birkel, Manfred, Schulz, Andreas, Hornberger, Martin, Liu, Kathy, Staiger, Kelly MacLennan, Krol, Helen Desiree, Deuschle, Ulrich, Steeneck, Christoph, Kinzel, Olaf, Liles, John T., Budas, Grant, Watkins, William J., Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (01.04.2024)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2024)
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Effect of fetal and infant growth on respiratory symptoms in preterm‐born children
Lowe, John, Kotecha, Sarah J., Watkins, William J., Kotecha, Sailesh
Published in Pediatric pulmonology (01.02.2018)
Published in Pediatric pulmonology (01.02.2018)
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Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis
Tang, Doris T, Du, Zhimin, Yang, Kin S, Bestvater, Brian P, Kaplan, Joshua, Neubig, Megan E, Olen, Casey L, Phillips, Bart, Wang, Peiyuan, Hudson, Thomas, Marchand, Bruno, Chan, Julie, Sharma, Monika, Hu, Yiding, Matles, Mike, Nejati, Elham, Chojnacka, Maja, Adams, Clifton, Pong, Cassie, Holsapple, Kevin, Budas, Grant, Tsui, Vickie, Venkataramani, Chandrasekar, Lazerwith, Scott E, Notte, Gregory T, Watkins, William J, McGlinchey, Ellen, Zagorska, Anna, Farand, Julie
Published in Journal of medicinal chemistry (21.11.2024)
Published in Journal of medicinal chemistry (21.11.2024)
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