Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats
SONGPING HAN, HAGAN, Deborah L, TAYLOR, Joseph R, LI XIN, WEI MENG, BILLER, Scott A, WETTERAU, John R, WASHBURN, William N, WHALEY, Jean M
Published in Diabetes (New York, N.Y.) (01.06.2008)
Published in Diabetes (New York, N.Y.) (01.06.2008)
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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor
Deshpande, Prashant P, Singh, Janak, Pullockaran, Annie, Kissick, Thomas, Ellsworth, Bruce A, Gougoutas, Jack Z, Dimarco, John, Fakes, Michael, Reyes, Mayra, Lai, Chiajen, Lobinger, Hidegard, Denzel, Theo, Ermann, Peter, Crispino, Gerard, Randazzo, Michael, Gao, Zenrong, Randazzo, Renee, Lindrud, Mark, Rosso, Victor, Buono, Frederic, Doubleday, Wendel W, Leung, Simon, Richberg, Pricilla, Hughes, David, Washburn, William N, Meng, Wei, Volk, Kevin J, Mueller, Richard H
Published in Organic process research & development (20.04.2012)
Published in Organic process research & development (20.04.2012)
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Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy
A. M. Subbaiah, Murugaiah, Mandal, Umasankar, Patankar, Vidya, Bhaskaran, Selvakumar, Nutakki, Ravikumar, Rami, Bhadresh, Shah, Devang Praful, Mahammad, Shahe, Murphy, Brian J., Huang, Christine, Robl, Jeffrey A., Washburn, William N.
Published in European journal of medicinal chemistry (05.10.2024)
Published in European journal of medicinal chemistry (05.10.2024)
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Chemical analysis of cacao residues in archaeological ceramics from North America: considerations of contamination, sample size and systematic controls
Washburn, Dorothy K., Washburn, William N., Shipkova, Petia A., Pelleymounter, Mary Ann
Published in Journal of archaeological science (01.10.2014)
Published in Journal of archaeological science (01.10.2014)
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Cacao consumption during the 8th century at Alkali Ridge, southeastern Utah
Washburn, Dorothy K., Washburn, William N., Shipkova, Petia A.
Published in Journal of archaeological science (01.04.2013)
Published in Journal of archaeological science (01.04.2013)
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Synthesis and Antiobesity Properties of 6‑(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2‑d]pyrimidin-4(3H)‑one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor
Ahmad, Saleem, Washburn, William N, Hernandez, Andres S, Bisaha, Sharon, Ngu, Khehyong, Wang, Wei, Pelleymounter, Mary Ann, Longhi, Daniel, Flynn, Neil, Azzara, Anthony V, Rohrbach, Kenneth, Devenny, James, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen, Harvey, Susan, Zhang, Hongwei, Gemzik, Brian, Janovitz, Evan B, Huang, Christine, Zhang, Lisa, Robl, Jeffrey A, Murphy, Brian J
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies
Devasthale, Pratik, Wang, Wei, Mignone, James, Renduchintala, Kishore, Radhakrishnan, Sridhar, Dhanapal, Jayanthi, Selvaraj, Jagannath, Kuppusamy, Rajesh, Pelleymounter, Mary Ann, Longhi, Daniel, Huang, Ning, Flynn, Neil, Azzara, Anthony V., Rohrbach, Kenneth, Devenny, James, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen, Harvey, Susan, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Huang, Christine, Zhang, Lisa, Freeden, Chris, Murphy, Brian J., Robl, Jeffrey A., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
Published in Bioorganic & medicinal chemistry letters (15.10.2015)
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Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate
Washburn, William N, Manfredi, Mark, Devasthale, Pratik, Zhao, Guohua, Ahmad, Saleem, Hernandez, Andres, Robl, Jeffrey A, Wang, Wei, Mignone, James, Wang, Zhenghua, Ngu, Khehyong, Pelleymounter, Mary Ann, Longhi, Daniel, Zhao, Rulin, Wang, Bei, Huang, Ning, Flynn, Neil, Azzara, Anthony V, Barrish, Joel C, Rohrbach, Kenneth, Devenny, James J, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen E, Harvey, Susan J, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Maxwell, Brad D, Yang, Hong, Apedo, Atsu, Gemzik, Brian, Janovitz, Evan B, Huang, Christine, Zhang, Lisa, Freeden, Chris, Murphy, Brian J
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup
Devasthale, Pratik, Wang, Wei, Hernandez, Andres S., Moore, Fang, Renduchintala, Kishore, Sridhar, Radhakrishnan, Pelleymounter, Mary Ann, Longhi, Daniel, Huang, Ning, Flynn, Neil, Azzara, Anthony V., Rohrbach, Kenneth, Devenny, James, Rooney, Suzanne, Thomas, Michael, Glick, Susan, Godonis, Helen, Harvey, Susan, Cullen, Mary Jane, Zhang, Hongwei, Caporuscio, Christian, Stetsko, Paul, Grubb, Mary, Huang, Christine, Zhang, Lisa, Freeden, Chris, Li, Yi-Xin, Murphy, Brian J., Robl, Jeffrey A., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2
Ellsworth, Bruce A., Meng, Wei, Patel, Manorama, Girotra, Ravindar N., Wu, Gang, Sher, Philip M., Hagan, Deborah L., Obermeier, Mary T., Humphreys, William G., Robertson, James G., Wang, Aiying, Han, Songping, Waldron, Thomas L., Morgan, Nathan N., Whaley, Jean M., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series
Ellsworth, Bruce A., Wang, Ying, Zhu, Yeheng, Pendri, Annapurna, Gerritz, Samuel W., Sun, Chongqing, Carlson, Kenneth E., Kang, Liya, Baska, Rose A., Yang, Yifan, Huang, Qi, Burford, Neil T., Cullen, Mary Jane, Johnghar, Susan, Behnia, Kamelia, Pelleymounter, Mary Ann, Washburn, William N., Ewing, William R.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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C-Arylglucoside synthesis: triisopropylsilane as a selective reagent for the reduction of an anomeric C-phenyl ketal
Ellsworth, Bruce A., Doyle, Abigail G., Patel, Manorama, Caceres-Cortes, Janet, Meng, Wei, Deshpande, Prashant P., Pullockaran, Annie, Washburn, William N.
Published in Tetrahedron: asymmetry (17.10.2003)
Published in Tetrahedron: asymmetry (17.10.2003)
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Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141
Garg, Neeraj, Li, Yi-Lin, Garcia Collazo, Ana Maria, Litten, Chris, Ryono, Denis E., Zhang, Minsheng, Caringal, Yolanda, Brigance, Robert P., Meng, Wei, Washburn, William N., Agback, Peter, Mellström, Karin, Rehnmark, Stefan, Rahimi-Ghadim, Mahmoud, Norin, Thomas, Grynfarb, Marlena, Sandberg, Johnny, Grover, Gary, Malm, Johan
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS
AHMAD SALEEM, BISAHA SHARON N, WASHBURN WILLIAM N, STEIN PHILIP D, NGU KHEHYONG
Year of Publication 30.04.2010
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Year of Publication 30.04.2010
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