CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Camacho-Pereira, Juliana, Tarragó, Mariana G., Chini, Claudia C.S., Nin, Veronica, Escande, Carlos, Warner, Gina M., Puranik, Amrutesh S., Schoon, Renee A., Reid, Joel M., Galina, Antonio, Chini, Eduardo N.
Published in Cell metabolism (14.06.2016)
Published in Cell metabolism (14.06.2016)
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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.
Published in Cell metabolism (01.05.2018)
Published in Cell metabolism (01.05.2018)
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The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Chini, Claudia, Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo
Published in Biochemical and biophysical research communications (28.05.2019)
Published in Biochemical and biophysical research communications (28.05.2019)
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CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
Published in Aging cell (01.04.2022)
Published in Aging cell (01.04.2022)
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p21 induces a senescence program and skeletal muscle dysfunction
Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A., Chini, Eduardo N., Baker, Darren J., van Deursen, Jan M., LeBrasseur, Nathan K.
Published in Molecular metabolism (Germany) (01.01.2023)
Published in Molecular metabolism (Germany) (01.01.2023)
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Dihydronicotinamide Riboside Is a Potent NAD + Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Chini, Claudia C S, Peclat, Thais R, Gomez, Lilian S, Zeidler, Julianna D, Warner, Gina M, Kashyap, Sonu, Mazdeh, Delaram Z, Hayat, Faisal, Migaud, Marie E, Paulus, Aneel, Chanan-Khan, Asher A, Chini, Eduardo N
Published in Frontiers in immunology (25.02.2022)
Published in Frontiers in immunology (25.02.2022)
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Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension
Kashyap, Sonu, Warner, Gina M, Hartono, Stella P, Boyilla, Rajendra, Knudsen, Bruce E, Zubair, Adeel S, Lien, Karen, Nath, Karl A, Textor, Stephen C, Lerman, Lilach O, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.03.2016)
Published in American journal of physiology. Renal physiology (01.03.2016)
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Low NAD + Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice
Meyer-Ficca, Mirella L, Zwerdling, Alexie E, Swanson, Corey A, Tucker, Abby G, Lopez, Sierra A, Wandersee, Miles K, Warner, Gina M, Thompson, Katie L, Chini, Claudia C S, Chen, Haolin, Chini, Eduardo N, Meyer, Ralph G
Published in Frontiers in endocrinology (Lausanne) (06.05.2022)
Published in Frontiers in endocrinology (Lausanne) (06.05.2022)
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Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model
Wang, Diping, Warner, Gina M, Yin, Ping, Knudsen, Bruce E, Cheng, Jingfei, Butters, Kim A, Lien, Karen R, Gray, Catherine E, Garovic, Vesna D, Lerman, Lilach O, Textor, Stephen C, Nath, Karl A, Simari, Robert D, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.04.2013)
Published in American journal of physiology. Renal physiology (01.04.2013)
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Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension
Cheng, Jingfei, Zhou, Wei, Warner, Gina M, Knudsen, Bruce E, Garovic, Vesna D, Gray, Catherine E, Lerman, Lilach O, Platt, Jeffrey L, Romero, J Carlos, Textor, Stephen C, Nath, Karl A, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.10.2009)
Published in American journal of physiology. Renal physiology (01.10.2009)
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A methionine-Mettl3-N 6 -methyladenosine axis promotes polycystic kidney disease
Ramalingam, Harini, Kashyap, Sonu, Cobo-Stark, Patricia, Flaten, Andrea, Chang, Chun-Mien, Hajarnis, Sachin, Hein, Kyaw Zaw, Lika, Jorgo, Warner, Gina M, Espindola-Netto, Jair M, Kumar, Ashwani, Kanchwala, Mohammed, Xing, Chao, Chini, Eduardo N, Patel, Vishal
Published in Cell metabolism (01.06.2021)
Published in Cell metabolism (01.06.2021)
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The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
Zeidler, Julianna D, Hogan, Kelly A, Agorrody, Guillermo, Peclat, Thais R, Kashyap, Sonu, Kanamori, Karina S, Gomez, Lilian Sales, Mazdeh, Delaram Z, Warner, Gina M, Thompson, Katie L, Chini, Claudia C S, Chini, Eduardo Nunes
Published in American Journal of Physiology: Cell Physiology (01.03.2022)
Published in American Journal of Physiology: Cell Physiology (01.03.2022)
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Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity
Peclat, Thais R, Agorrody, Guillermo, Colman, Laura, Kashyap, Sonu, Zeidler, Julianna D, Chini, Claudia C S, Warner, Gina M, Thompson, Katie L, Dalvi, Pranjali, Beckedorff, Felipe, Ebtehaj, Sanam, Herrmann, Joerg, van Schooten, Wim, Chini, Eduardo Nunes
Published in Cardiovascular research (14.03.2024)
Published in Cardiovascular research (14.03.2024)
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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels
Chini, Claudia C S, Peclat, Thais R, Warner, Gina M, Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C, Gomez, Lilian S, Hogan, Kelly A, Tarragó, Mariana G, Puranik, Amrutesh S, Agorrody, Guillermo, Thompson, Katie L, Dang, Kevin, Clarke, Starlynn, Childs, Bennett G, Kanamori, Karina S, Witte, Micaela A, Vidal, Paola, Kirkland, Anna L, De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R, Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L, Sedivy, John M, van Deursen, Jan M, Baker, Darren J, van Schooten, Wim, Rabinowitz, Joshua D, Baur, Joseph A, Chini, Eduardo N
Published in Nature metabolism (01.11.2020)
Published in Nature metabolism (01.11.2020)
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Signaling pathways modulated by fish oil in salt-sensitive hypertension
Diaz Encarnacion, Montserrat M, Warner, Gina M, Gray, Catherine E, Cheng, Jingfei, Keryakos, Hesham K H, Nath, Karl A, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.06.2008)
Published in American journal of physiology. Renal physiology (01.06.2008)
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FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua
Published in Cell reports (Cambridge) (03.08.2021)
Published in Cell reports (Cambridge) (03.08.2021)
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Genetic deficiency of Smad3 protects against murine ischemic acute kidney injury
Nath, Karl A, Croatt, Anthony J, Warner, Gina M, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.08.2011)
Published in American journal of physiology. Renal physiology (01.08.2011)
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Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4
Cheng, Jingfei, Thompson, Michael A, Walker, Henry J, Gray, Catherine E, Diaz Encarnacion, Montserrat M, Warner, Gina M, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.11.2004)
Published in American journal of physiology. Renal physiology (01.11.2004)
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Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension
Warner, Gina M, Cheng, Jingfei, Knudsen, Bruce E, Gray, Catherine E, Deibel, Ansgar, Juskewitch, Justin E, Lerman, Lilach O, Textor, Stephen C, Nath, Karl A, Grande, Joseph P
Published in American journal of physiology. Renal physiology (01.06.2012)
Published in American journal of physiology. Renal physiology (01.06.2012)
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Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
Kashyap, Sonu, Hein, Kyaw Zaw, Chini, Claudia Cs, Lika, Jorgo, Warner, Gina M, Bale, Laurie K, Torres, Vicente E, Harris, Peter C, Oxvig, Claus, Conover, Cheryl A, Chini, Eduardo N
Published in JCI insight (27.02.2020)
Published in JCI insight (27.02.2020)
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