Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry
Barnes, Matthew J., Conroy, Richard, Miller, David J., Mills, John S., Montana, John G., Pooni, Parminder K., Showell, Graham A., Walsh, Louise M., Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Journal Article
( R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis
Showell, Graham A., Barnes, Matthew J., Daiss, Jürgen O., Mills, John S., Montana, John G., Tacke, Reinhold, Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization
Barnes, Matthew J., Burschka, Christian, Büttner, Matthias W., Conroy, Richard, Daiss, Jürgen O., Gray, Ian C., Hendrick, Alan G., Tam, L. H., Kuehn, Diana, Miller, David J., Mills, John S., Mitchell, Philip, Montana, John G., Muniandy, Parameswary A., Rapley, Helen, Showell, Graham A., Tebbe, David, Tacke, Reinhold, Warneck, Julie B. H., Zhu, Bin
Published in ChemMedChem (04.11.2011)
Published in ChemMedChem (04.11.2011)
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Journal Article
Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization
Daiss, Jürgen O, Burschka, Christian, Mills, John S, Montana, John G, Showell, Graham A, Warneck, Julie B. H, Tacke, Reinhold
Published in Organometallics (27.02.2006)
Published in Organometallics (27.02.2006)
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Journal Article
Action of ( R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret
Warneck, Julie B., Cheng, Frankie H.M., Barnes, Matthew J., Mills, John S., Montana, John G., Naylor, Robert J., Ngan, Man-P., Wai, Man-K., Daiss, Jürgen O., Tacke, Reinhold, Rudd, John A.
Published in Toxicology and applied pharmacology (01.11.2008)
Published in Toxicology and applied pharmacology (01.11.2008)
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Journal Article
Syntheses and Pharmacological Properties of the Histaminic H1 Antagonists Sila-terfenadine-A, Sila-terfenadine-B, Disila-terfenadine, and Sila-fexofenadine: A Study on C/Si Bioisosterism
Tacke, Reinhold, Schmid, Thomas, Penka, Martin, Burschka, Christian, Bains, William, Warneck, Julie
Published in Organometallics (11.10.2004)
Published in Organometallics (11.10.2004)
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Journal Article
Synthesis, crystal structure analysis, and pharmacological characterization of desmethoxy-sila-venlafaxine, a derivative of the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine
Daiß, Jürgen O., Burschka, Christian, Mills, John S., Montana, John G., Showell, Graham A., Warneck, Julie B.H., Tacke, Reinhold
Published in Journal of organometallic chemistry (15.08.2006)
Published in Journal of organometallic chemistry (15.08.2006)
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Journal Article
7-Methoxyfuro[2,3- c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma
Buckley, George M, Cooper, Nicola, Davenport, Richard J, Dyke, Hazel J, Galleway, Fiona P, Gowers, Lewis, Haughan, Alan F, Kendall, Hannah J, Lowe, Christopher, Montana, John G, Oxford, Janet, Peake, Joanna C, Picken, C.Louise, Richard, Marianna D, Sabin, Verity, Sharpe, Andrew, Warneck, Julie B.H
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Journal Article
Synthesis and profile of SCH351591, a novel PDE4 inhibitor
Billah, Motasim, Cooper, Nicola, Cuss, Francis, Davenport, Richard J., Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Hannah, Duncan R., Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Piwinski, John J., Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Shih, Neng-Yang, Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
8-Methoxyquinolines as PDE4 inhibitors
Billah, Motasim, Buckley, George M., Cooper, Nicola, Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Oxford, Janet, Peake, Joanna C., Picken, C.Louise, Piwinski, John J., Naylor, Robert, Sabin, Verity, Shih, Neng-Yang, Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma
Buckley, George M., Cooper, Nicola, Dyke, Hazel J., Galleway, Fiona P., Gowers, Lewis, Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Maxey, Robert, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Picken, C.Louise, Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease
Brown, Alastair J H, Bradley, Sophie J, Marshall, Fiona H, Brown, Giles A, Bennett, Kirstie A, Brown, Jason, Cansfield, Julie E, Cross, David M, de Graaf, Chris, Hudson, Brian D, Dwomoh, Louis, Dias, João M, Errey, James C, Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J, Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C, Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M, Goonawardena, Anushka V, Morairty, Stephen R, Browning, Michael, Perini, Francesca, Dawson, Gerard R, Deakin, John F W, Smith, Robert T, Sexton, Patrick M, Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G, Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J, Jazayeri, Ali, Cooke, Robert M, Rucktooa, Prakash, Congreve, Miles S, Weir, Malcolm, Tobin, Andrew B
Published in Cell (24.11.2021)
Published in Cell (24.11.2021)
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Journal Article
7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma
Buckley, George, Cooper, Nicola, Dyke, Hazel J, Galleway, Fiona, Gowers, Lewis, Gregory, Joanna C, Hannah, Duncan R, Haughan, Alan F, Hellewell, Paul G, Kendall, Hannah J, Lowe, Christopher, Maxey, Robert, Montana, John G, Naylor, Robert, Picken, C.Louise, Runcie, Karen A, Sabin, Verity, Tuladhar, Bishwa R, Warneck, Julie B.H
Published in Bioorganic & medicinal chemistry letters (18.09.2000)
Published in Bioorganic & medicinal chemistry letters (18.09.2000)
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Journal Article
A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo
Cooper, Nicola, Teixeira, Mauro M, Warneck, Julie, Miotla, Jadwiga M, Wills, Ruth E, Macari, David M T, Gristwood, Robert W, Hellewell, Paul G
Published in British journal of pharmacology (01.04.1999)
Published in British journal of pharmacology (01.04.1999)
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Journal Article
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
Brown, Alastair J.H., Bradley, Sophie J., Marshall, Fiona H., Brown, Giles A., Bennett, Kirstie A., Brown, Jason, Cansfield, Julie E., Cross, David M., de Graaf, Chris, Hudson, Brian D., Dwomoh, Louis, Dias, João M., Errey, James C., Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J., Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C., Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M., Goonawardena, Anushka V., Morairty, Stephen R., Browning, Michael, Perini, Francesca, Dawson, Gerard R., Deakin, John F.W., Smith, Robert T., Sexton, Patrick M., Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G., Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J., Jazayeri, Ali, Cooke, Robert M., Rucktooa, Prakash, Congreve, Miles S., Weir, Malcolm, Tobin, Andrew B.
Published in Cell (24.11.2021)
Published in Cell (24.11.2021)
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Journal Article
Aryl sulfonamides as selective PDE4 inhibitors
Montana, John G, Buckley, George M, Cooper, Nicola, Dyke, Hazel J, Gowers, Lewis, Gregory, Joanna P, Hellewell, Paul G, Kendall, Hannah J, Lowe, Christopher, Maxey, Robert, Miotla, Jadwiga, Naylor, Robert J, Runcie, Karen A, Tuladhar, Bishwa, Warneck, Julie B.H
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
Published in Bioorganic & medicinal chemistry letters (06.10.1998)
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Journal Article
PDE4 inhibitors: New xanthine analogues
Montana, John G, Cooper, Nicola, Dyke, Hazel J, Gowers, Lewis, Gregory, Joanna P, Hellewell, Paul G, Miotla, Jadwiga, Morris, Ken, Naylor, Robert, Tuladhar, Bishwa, Warneck, Julie BH
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
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Journal Article
Synthesis and Pharmacological Properties of Silicon-Containing 1,4-Dihydropyridine Derivatives: Calcium Channel Antagonists and α1 Adrenoceptor Antagonists of the Sila-niguldipine Type
Heinrich, Tilman, Burschka, Christian, Warneck, Julie, Tacke, Reinhold
Published in Organometallics (02.02.2004)
Published in Organometallics (02.02.2004)
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Journal Article
Syntheses and pharmacological properties of the histaminic H-1 antagonists sila-terfenadine-A, sila-terfenadine-B, disila-terfenadine, and sila-fexofenadine: A study on C/Si bioisosterism
Tacke, R, Schmid, T, Penka, M, Burschka, C, Bains, W, Warneck, J
Published in Organometallics (11.10.2004)
Published in Organometallics (11.10.2004)
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Journal Article