A chemistry wiki to facilitate and enhance compound design in drug discovery
Robb, Graeme R., McKerrecher, Darren, Newcombe, Nicholas J., Waring, Mike J.
Published in Drug discovery today (01.02.2013)
Published in Drug discovery today (01.02.2013)
Get full text
Journal Article
Abstract 4744: Structure-based development of covalent inhibitors of the activating and T790M gatekeeper mutant forms of the epidermal growth factor receptor (EGFR) leading to the discovery of AZD9291
Ward, Richard A., Ashton, Susan, Anderton, Mark, Ballard, Pete G., Bradbury, Rob H., Butterworth, Sam, Colclough, Nicola, Cross, Darren A E, Finlay, M Ray V., McFarland, Heather L., Mellor, Martine, Waring, Mike J.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract B94: Discovery of and first disclosure of the clinical candidate AZD9291, a potent and selective third-generation EGFR inhibitor of both activating and T790M resistant mutations that spares the wild type form of the receptor
Finlay, M. Raymond V., Anderton, Mark, Ashton, Susan, Ballard, Peter G., Bradbury, Rob H., Butterworth, Sam, Chuaqui, Claudio E., Colclough, Nicola, Cross, Darren A. E., McFarland, Heather L., Mellor, Martine J., Ward, Richard A., Waring, Mike J.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
Get full text
Journal Article