Application of an LC–MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique
Harwood, M.D., Achour, B., Russell, M.R., Carlson, G.L., Warhurst, G., Rostami-Hodjegan, A.
Published in Journal of pharmaceutical and biomedical analysis (10.06.2015)
Published in Journal of pharmaceutical and biomedical analysis (10.06.2015)
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Journal Article
Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption
Harwood, M. D., Neuhoff, S., Carlson, G. L., Warhurst, G., Rostami-Hodjegan, A.
Published in Biopharmaceutics & drug disposition (01.01.2013)
Published in Biopharmaceutics & drug disposition (01.01.2013)
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Journal Article
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey
Published in Drug metabolism and disposition (01.03.2016)
Published in Drug metabolism and disposition (01.03.2016)
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Journal Article
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey, Rostami-Hodjegan, Amin
Published in Drug metabolism and disposition (01.03.2016)
Published in Drug metabolism and disposition (01.03.2016)
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Journal Article
Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation
Glymenaki, M., Barnes, A., Hagan, S. O’, Warhurst, G., McBain, A. J., Wilson, I. D., Kell, D. B., Else, K. J., Cruickshank, S. M.
Published in Scientific reports (18.08.2017)
Published in Scientific reports (18.08.2017)
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Journal Article
Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?
Collett, Andrew, Tanianis-Hughes, Jolanta, Warhurst, Geoff
Published in Biochemical pharmacology (15.08.2004)
Published in Biochemical pharmacology (15.08.2004)
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Journal Article
Region-Dependent Modulation of Intestinal Permeability by Drug Efflux Transporters: In Vitro Studies in mdr1a(â/â) Mouse Intestine
Stephens, R. H., Tanianis-Hughes, J., Higgs, N. B., Humphrey, M., Warhurst, G.
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
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Journal Article
Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1
McLaughlin, J. T., Lomax, R. B., Hall, L., Dockray, G. J., Thompson, D. G., Warhurst, G.
Published in The Journal of physiology (15.11.1998)
Published in The Journal of physiology (15.11.1998)
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Journal Article
Modulation of the Permeability of H2 Receptor Antagonists Cimetidine and Ranitidine by P-Glycoprotein in Rat Intestine and the Human Colonic Cell Line Caco-2
Collett, A, Higgs, N B, Sims, E, Rowland, M, Warhurst, G
Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
Journal Article
Resolution of P‐glycoprotein and non‐P‐glycoprotein effects on drug permeability using intestinal tissues from mdr1a (−/−) mice
Stephens, R H, O'Neill, C A, Bennett, J, Humphrey, M, Henry, B, Rowland, M, Warhurst, G
Published in British journal of pharmacology (01.04.2002)
Published in British journal of pharmacology (01.04.2002)
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Journal Article
Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the α-Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003) : The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption
COLLETT, A, STEPHENS, R. H, HARWOOD, M. D, HUMPHREY, M, DALLMAN, L, BENNETT, J, DAVIS, J, CARLSON, G. L, WARHURST, G
Published in Drug metabolism and disposition (2008)
Published in Drug metabolism and disposition (2008)
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Journal Article
Characterization of apical potassium channels induced in rat distal colon during potassium adaptation
Butterfield, I., Warhurst, G., Jones, M. N., Sandle, G. I.
Published in The Journal of physiology (15.06.1997)
Published in The Journal of physiology (15.06.1997)
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