Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, Jason, Kheradpour, Pouya, Mikkelsen, Tarjei S., Shoresh, Noam, Ward, Lucas D., Epstein, Charles B., Zhang, Xiaolan, Wang, Li, Issner, Robbyn, Coyne, Michael, Ku, Manching, Durham, Timothy, Kellis, Manolis, Bernstein, Bradley E.
Published in Nature (London) (05.05.2011)
Published in Nature (London) (05.05.2011)
Get full text
Journal Article
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.
Published in Nature communications (05.04.2019)
Published in Nature communications (05.04.2019)
Get full text
Journal Article
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Lee, Mark N., Ye, Chun, Villani, Alexandra-Chloé, Raj, Towfique, Li, Weibo, Eisenhaure, Thomas M., Imboywa, Selina H., Chipendo, Portia I., Ran, F. Ann, Slowikowski, Kamil, Ward, Lucas D., Raddassi, Khadir, McCabe, Cristin, Lee, Michelle H., Frohlich, Irene Y., Hafler, David A., Kellis, Manolis, Raychaudhuri, Soumya, Zhang, Feng, Stranger, Barbara E., Benoist, Christophe O., De Jager, Philip L., Regev, Aviv, Hacohen, Nir
Published in Science (American Association for the Advancement of Science) (07.03.2014)
Published in Science (American Association for the Advancement of Science) (07.03.2014)
Get full text
Journal Article
Defining functional DNA elements in the human genome
Kellis, Manolis, Wold, Barbara, Snyderd, Michael P., Bernstein, Bradley E., Kundaje, Anshul, Marinov, Georgi K., Ward, Lucas D., Birney, Ewan, Crawford, Gregory E., Dekker, Job, Dunham, Ian, Elnitski, Laura L., Farnham, Peggy J., Feingold, Elise A., Gerstein, Mark, Giddings, Morgan C., Gilbert, David M., Gingeras, Thomas R., Green, Eric D., Guigo, Roderic, Hubbard, Tim, Kent, Jim, Lieb, Jason D., Myerst, Richard M., Pazin, Michael J., Ren, Bing, Stamatoyannopoulos, John A., Weng, Zhiping, White, Kevin P., Hardison, Ross C.
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
Get full text
Journal Article
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity
Deaton, Aimee M., Dubey, Aditi, Ward, Lucas D., Dornbos, Peter, Flannick, Jason, Yee, Elaine, Ticau, Simina, Noetzli, Leila, Parker, Margaret M., Hoffing, Rachel A., Willis, Carissa, Plekan, Mollie E., Holleman, Aaron M., Hinkle, Gregory, Fitzgerald, Kevin, Vaishnaw, Akshay K., Nioi, Paul
Published in Nature communications (27.07.2022)
Published in Nature communications (27.07.2022)
Get full text
Journal Article
A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing
Liu, Xin, Zhang, Ye, Ward, Lucas D., Yan, Qinghong, Bohnuud, Tanggis, Hernandez, Rocio, Lao, Socheata, Yuan, Jing, Fan, Fan
Published in Scientific reports (04.08.2021)
Published in Scientific reports (04.08.2021)
Get full text
Journal Article
Epigenetic and genetic components of height regulation
Benonisdottir, Stefania, Oddsson, Asmundur, Helgason, Agnar, Kristjansson, Ragnar P., Sveinbjornsson, Gardar, Oskarsdottir, Arna, Thorleifsson, Gudmar, Davidsson, Olafur B., Arnadottir, Gudny A., Sulem, Gerald, Jensson, Brynjar O., Holm, Hilma, Alexandersson, Kristjan F., Tryggvadottir, Laufey, Walters, G. Bragi, Gudjonsson, Sigurjon A., Ward, Lucas D., Sigurdsson, Jon K., Iordache, Paul D., Frigge, Michael L., Rafnar, Thorunn, Kong, Augustine, Masson, Gisli, Helgason, Hannes, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, Stefansson, Kari
Published in Nature communications (16.11.2016)
Published in Nature communications (16.11.2016)
Get full text
Journal Article
Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry
Parker, Margaret M., Damrauer, Scott M., Tcheandjieu, Catherine, Erbe, David, Aldinc, Emre, Hawkins, Philip N., Gillmore, Julian D., Hull, Leland E., Lynch, Julie A., Joseph, Jacob, Ticau, Simina, Flynn-Carroll, Alexander O., Deaton, Aimee M., Ward, Lucas D., Assimes, Themistocles L., Tsao, Philip S., Chang, Kyong-Mi, Rader, Daniel J., Fitzgerald, Kevin, Vaishnaw, Akshay K., Hinkle, Gregory, Nioi, Paul
Published in Scientific reports (02.06.2021)
Published in Scientific reports (02.06.2021)
Get full text
Journal Article
Hotspots of transcription factor colocalization in the genome of Drosophila melanogaster
Moorman, C, Sun, L.V, Wang, J, Wit, E. de, Talhout, W, Ward, L.D, Greil, F, Lu, X.J, White, K.P, Bussemaker, H.J
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (08.08.2006)
Get full text
Journal Article
Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease
Kellis, Manolis, Wold, Barbara, Snyder, Michael P, Bernstein, Bradley E, Kundaje, Anshul, Marinov, Georgi K, Ward, Lucas D, Birney, Ewan, Crawford, Gregory E, Dekker, Job, Dunham, Ian, Elnitski, Laura L, Farnham, Peggy J, Feingold, Elise A, Gerstein, Mark, Giddings, Morgan C, Gilbert, David M, Gingeras, Thomas R, Green, Eric D, Guigo, Roderic, Hubbard, Tim, Kent, Jim, Lieb, Jason D, Myers, Richard M, Pazin, Michael J, Ren, Bing, Stamatoyannopoulos, John, Weng, Zhiping, White, Kevin P, Hardison, Ross C
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Get full text
Journal Article
Parental influence on human germline de novo mutations in 1,548 trios from Iceland
Jónsson, Hákon, Sulem, Patrick, Kehr, Birte, Kristmundsdottir, Snaedis, Zink, Florian, Hjartarson, Eirikur, Hardarson, Marteinn T., Hjorleifsson, Kristjan E., Eggertsson, Hannes P., Gudjonsson, Sigurjon Axel, Ward, Lucas D., Arnadottir, Gudny A., Helgason, Einar A., Helgason, Hannes, Gylfason, Arnaldur, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Rafnar, Thorunn, Frigge, Mike, Stacey, Simon N., Th. Magnusson, Olafur, Thorsteinsdottir, Unnur, Masson, Gisli, Kong, Augustine, Halldorsson, Bjarni V., Helgason, Agnar, Gudbjartsson, Daniel F., Stefansson, Kari
Published in Nature (London) (28.09.2017)
Published in Nature (London) (28.09.2017)
Get full text
Journal Article
Using human genetics to improve safety assessment of therapeutics
Carss, Keren J., Deaton, Aimee M., Del Rio-Espinola, Alberto, Diogo, Dorothée, Fielden, Mark, Kulkarni, Diptee A., Moggs, Jonathan, Newham, Peter, Nelson, Matthew R., Sistare, Frank D., Ward, Lucas D., Yuan, Jing
Published in Nature reviews. Drug discovery (01.02.2023)
Published in Nature reviews. Drug discovery (01.02.2023)
Get full text
Journal Article
A high-resolution map of human evolutionary constraint using 29 mammals
Lindblad-Toh, Kerstin, Garber, Manuel, Zuk, Or, Lin, Michael F., Parker, Brian J., Washietl, Stefan, Kheradpour, Pouya, Ernst, Jason, Jordan, Gregory, Mauceli, Evan, Ward, Lucas D., Lowe, Craig B., Holloway, Alisha K., Clamp, Michele, Gnerre, Sante, Alföldi, Jessica, Beal, Kathryn, Chang, Jean, Clawson, Hiram, Cuff, James, Di Palma, Federica, Fitzgerald, Stephen, Flicek, Paul, Guttman, Mitchell, Hubisz, Melissa J., Jaffe, David B., Jungreis, Irwin, Kent, W. James, Kostka, Dennis, Lara, Marcia, Martins, Andre L., Massingham, Tim, Moltke, Ida, Raney, Brian J., Rasmussen, Matthew D., Robinson, Jim, Stark, Alexander, Vilella, Albert J., Wen, Jiayu, Xie, Xiaohui, Zody, Michael C., Worley, Kim C., Kovar, Christie L., Muzny, Donna M., Gibbs, Richard A., Warren, Wesley C., Mardis, Elaine R., Weinstock, George M., Wilson, Richard K., Birney, Ewan, Margulies, Elliott H., Herrero, Javier, Green, Eric D., Haussler, David, Siepel, Adam, Goldman, Nick, Pollard, Katherine S., Pedersen, Jakob S., Lander, Eric S., Kellis, Manolis
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
Get full text
Journal Article